SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y63'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 4y63 HISTO-BLOOD GROUP
ABO SYSTEM
TRANSFERASE
(Homo
sapiens) 		5 / 11 LEU A 280
LEU A 310
ARG A 188
ILE A 192
THR A 316
 None
None
48O  A 402 (-3.6A)
None
None
 1.21A 2qd3A-4y63A:
undetectable		 2qd3A-4y63A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 4y63 HISTO-BLOOD GROUP
ABO SYSTEM
TRANSFERASE
(Homo
sapiens) 		5 / 10 VAL A 277
LEU A 324
LEU A 306
GLY A 267
ALA A 268
 None
 1.19A 2xf3A-4y63A:
undetectable		 2xf3A-4y63A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 4y63 HISTO-BLOOD GROUP
ABO SYSTEM
TRANSFERASE
(Homo
sapiens) 		5 / 9 LEU A 280
LEU A 228
ILE A 224
ILE A 116
PHE A 270
 None
 1.50A 3tmzA-4y63A:
undetectable		 3tmzA-4y63A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 4y63 HISTO-BLOOD GROUP
ABO SYSTEM
TRANSFERASE
(Homo
sapiens) 		4 / 5 LEU A 118
GLY A 117
MET A 142
PHE A 269
 None
 1.24A 3uq6B-4y63A:
undetectable		 3uq6B-4y63A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 4y63 HISTO-BLOOD GROUP
ABO SYSTEM
TRANSFERASE
(Homo
sapiens) 		4 / 4 LEU A 118
GLY A 117
MET A 142
PHE A 269
 None
 1.18A 3vaqB-4y63A:
undetectable		 3vaqB-4y63A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 4y63 HISTO-BLOOD GROUP
ABO SYSTEM
TRANSFERASE
(Homo
sapiens) 		4 / 6 GLY A 230
LEU A 310
ASN A 307
GLU A 303
 None
None
None
BHE  A 401 (-2.6A)
 0.99A 3zqtA-4y63A:
undetectable		 3zqtA-4y63A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4y63 HISTO-BLOOD GROUP
ABO SYSTEM
TRANSFERASE
(Homo
sapiens) 		4 / 6 GLU A 138
PHE A 133
HIS A 145
VAL A 204
 None
 1.19A 4a97E-4y63A:
undetectable		 4a97E-4y63A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 4y63 HISTO-BLOOD GROUP
ABO SYSTEM
TRANSFERASE
(Homo
sapiens) 		4 / 7 PHE A 229
VAL A  95
GLY A 221
PHE A 269
 None
 0.93A 4ejjB-4y63A:
undetectable		 4ejjB-4y63A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 4y63 HISTO-BLOOD GROUP
ABO SYSTEM
TRANSFERASE
(Homo
sapiens) 		5 / 12 GLY A 266
GLY A 267
GLY A 230
ILE A  94
PRO A 321
 None
 0.96A 4rtmA-4y63A:
undetectable		 4rtmA-4y63A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		 4y63 HISTO-BLOOD GROUP
ABO SYSTEM
TRANSFERASE
(Homo
sapiens) 		5 / 12 ILE A 224
LEU A 324
VAL A 210
LEU A 225
PHE A 229
 None
 1.00A 5bykA-4y63A:
undetectable		 5bykA-4y63A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4y63 HISTO-BLOOD GROUP
ABO SYSTEM
TRANSFERASE
(Homo
sapiens) 		4 / 5 GLY A 167
THR A 166
GLY A 230
LEU A 118
 None
 0.92A 5jlcA-4y63A:
undetectable		 5jlcA-4y63A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 4y63 HISTO-BLOOD GROUP
ABO SYSTEM
TRANSFERASE
(Homo
sapiens) 		3 / 3 ARG A 241
PHE A 244
GLY A 261
 None
 0.82A 6fgdA-4y63A:
undetectable		 6fgdA-4y63A:
22.25