SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y6o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		4 / 8 TYR A 139
SER A  88
ILE A  93
LEU A 172
 None
 0.87A 1eupA-4y6oA:
undetectable		 1eupA-4y6oA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 GLY A 305
GLY A 304
ASP A 310
PHE A 309
ASN A 286
 None
 0.91A 1qzzA-4y6oA:
4.3		 1qzzA-4y6oA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		 4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 LEU A 335
LEU A 329
GLN A 326
LEU A 258
MET A 260
 None
 1.25A 1sqnA-4y6oA:
undetectable		 1sqnA-4y6oA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 GLY A 305
GLY A 304
ASP A 310
PHE A 309
ASN A 286
 None
 0.91A 1xdsB-4y6oA:
4.4		 1xdsB-4y6oA:
21.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 6 ALA A  85
SER A  88
ASN A 168
ILE A 169
ASP A 170
 None
 0.29A 1yc2A-4y6oA:
20.1		 1yc2A-4y6oA:
30.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		4 / 5 ALA A  85
ASN A 168
ILE A 169
ASP A 170
 None
 0.31A 1yc2D-4y6oA:
20.0		 1yc2D-4y6oA:
30.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		4 / 7 ILE A  93
ASN A 168
ILE A 169
ASP A 170
 None
 0.45A 1yc2E-4y6oA:
20.7		 1yc2E-4y6oA:
30.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		7 / 7 ALA A  85
SER A  88
ILE A  93
ASP A  95
ASN A 168
ILE A 169
ASP A 170
 None
 0.38A 1yc5A-4y6oA:
10.7		 1yc5A-4y6oA:
34.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 5 ALA A  85
ILE A  93
ASN A 168
ILE A 169
ASP A 170
 None
 0.36A 2h4jA-4y6oA:
26.9		 2h4jA-4y6oA:
34.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		 4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 LEU A 335
LEU A 329
GLN A 326
LEU A 258
MET A 260
 None
 1.29A 2w8yB-4y6oA:
undetectable		 2w8yB-4y6oA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		4 / 8 TYR A 165
LEU A 272
LYS A 275
ALA A 276
 None
 0.73A 2wekA-4y6oA:
undetectable		 2wekA-4y6oA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 LEU A 335
LEU A 329
GLN A 326
LEU A 258
MET A 260
 None
 1.26A 3d90A-4y6oA:
undetectable		 3d90A-4y6oA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 11 CYH A 164
LEU A 178
LYS A 156
LEU A 155
VAL A  83
 None
 1.26A 3e22B-4y6oA:
3.1		 3e22B-4y6oA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_1
(ADENOSINE KINASE)		 4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 ILE A  87
GLY A 261
GLY A  86
THR A 146
LEU A 172
 None
 1.02A 3uboB-4y6oA:
4.3		 3uboB-4y6oA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		4 / 4 ASN A 168
ALA A  85
GLY A  84
THR A 262
 None
 1.27A 4bboC-4y6oA:
undetectable		 4bboC-4y6oA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_1
(SUGAR KINASE PROTEIN)		 4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 ILE A  87
GLY A 261
GLY A  86
THR A 146
LEU A 172
 None
 1.00A 4e3aA-4y6oA:
4.6		 4e3aA-4y6oA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_B_ADNB500_1
(SUGAR KINASE PROTEIN)		 4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		6 / 12 ILE A  87
GLY A 261
GLY A  86
THR A 146
LEU A 172
GLY A 322
 None
 1.37A 4e3aB-4y6oA:
4.7		 4e3aB-4y6oA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 LEU A 331
LEU A 154
LEU A 155
ILE A 285
LEU A 329
 None
 1.12A 4j24A-4y6oA:
undetectable		 4j24A-4y6oA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 LEU A 335
LEU A 154
LEU A 155
ILE A 285
LEU A 329
 None
 1.29A 4j24C-4y6oA:
undetectable		 4j24C-4y6oA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_B_ADNB500_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 ILE A  87
GLY A 261
GLY A  86
THR A 146
LEU A 172
 None
 0.98A 4jkuB-4y6oA:
4.5		 4jkuB-4y6oA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_A_ADNA401_1
(SUGAR KINASE)		 4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 ILE A  87
GLY A 261
GLY A  86
THR A 146
LEU A 172
 None
 0.99A 4k8pA-4y6oA:
4.5		 4k8pA-4y6oA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_B_ADNB401_1
(SUGAR KINASE)		 4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 ILE A  87
GLY A 261
GLY A  86
THR A 146
LEU A 172
 None
 0.99A 4k8pB-4y6oA:
4.5		 4k8pB-4y6oA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_A_ADNA401_1
(SUGAR KINASE)		 4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 ILE A  87
GLY A 261
GLY A  86
THR A 146
LEU A 172
 None
 0.98A 4k8tA-4y6oA:
4.6		 4k8tA-4y6oA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_B_ADNB401_1
(SUGAR KINASE)		 4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 ILE A  87
GLY A 261
GLY A  86
THR A 146
LEU A 172
 None
 0.98A 4k8tB-4y6oA:
4.3		 4k8tB-4y6oA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_A_ADNA401_1
(SUGAR KINASE)		 4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 ILE A  87
GLY A 261
GLY A  86
THR A 146
LEU A 172
 None
 0.99A 4k93A-4y6oA:
4.0		 4k93A-4y6oA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_B_ADNB402_1
(SUGAR KINASE)		 4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 ILE A  87
GLY A 261
GLY A  86
THR A 146
LEU A 172
 None
 1.00A 4k93B-4y6oA:
4.3		 4k93B-4y6oA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_A_ADNA401_1
(SUGAR KINASE)		 4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 ILE A  87
GLY A 261
GLY A  86
THR A 146
LEU A 172
 None
 0.98A 4k9cA-4y6oA:
4.5		 4k9cA-4y6oA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_B_ADNB401_1
(SUGAR KINASE)		 4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 ILE A  87
GLY A 261
GLY A  86
THR A 146
LEU A 172
 None
 0.99A 4k9cB-4y6oA:
4.5		 4k9cB-4y6oA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_A_ADNA401_1
(SUGAR KINASE)		 4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 ILE A  87
GLY A 261
GLY A  86
THR A 146
LEU A 172
 None
 1.01A 4k9iA-4y6oA:
4.6		 4k9iA-4y6oA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_B_ADNB401_1
(SUGAR KINASE)		 4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 ILE A  87
GLY A 261
GLY A  86
THR A 146
LEU A 172
 None
 1.00A 4k9iB-4y6oA:
4.0		 4k9iB-4y6oA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 ILE A  87
GLY A 261
GLY A  86
THR A 146
LEU A 172
 None
 0.98A 4kadA-4y6oA:
3.6		 4kadA-4y6oA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 ILE A  87
GLY A 261
GLY A  86
THR A 146
LEU A 172
 None
 1.00A 4kadB-4y6oA:
4.1		 4kadB-4y6oA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 ILE A  87
GLY A 261
GLY A  86
THR A 146
LEU A 172
 None
 1.00A 4lbxA-4y6oA:
4.5		 4lbxA-4y6oA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 ILE A  87
GLY A 261
GLY A  86
THR A 146
LEU A 172
 None
 1.00A 4lbxB-4y6oA:
4.3		 4lbxB-4y6oA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 ILE A  87
GLY A 261
GLY A  86
THR A 146
LEU A 172
 None
 0.98A 4lc4A-4y6oA:
4.5		 4lc4A-4y6oA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 ILE A  87
GLY A 261
GLY A  86
THR A 146
LEU A 172
 None
 0.99A 4lc4B-4y6oA:
4.5		 4lc4B-4y6oA:
22.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		4 / 7 ILE A  93
ASN A 168
ILE A 169
ASP A 170
 None
 0.39A 4rmjA-4y6oA:
38.8		 4rmjA-4y6oA:
95.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6L_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 9 ILE A 169
ALA A 186
LEU A 183
ILE A  87
PRO A 145
 None
 1.37A 5z6lA-4y6oA:
undetectable		 5z6lA-4y6oA:
21.48