SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y7d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Nakamurella
multipartita) 		3 / 3 ARG A  65
GLY A 216
ASP A 220
 None
 0.35A 1kf6A-4y7dA:
undetectable
1kf6B-4y7dA:
undetectable		 1kf6A-4y7dA:
21.58
1kf6B-4y7dA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Nakamurella
multipartita) 		5 / 12 ILE A 172
VAL A 280
ALA A 129
SER A 104
GLY A 273
 None
None
None
None
CL  A 501 ( 3.7A)
 1.06A 1kiaA-4y7dA:
2.7		 1kiaA-4y7dA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Nakamurella
multipartita) 		5 / 12 ILE A 172
VAL A 280
ALA A 129
SER A 104
GLY A 273
 None
None
None
None
CL  A 501 ( 3.7A)
 1.06A 1nbhB-4y7dA:
2.6		 1nbhB-4y7dA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Nakamurella
multipartita) 		5 / 12 ILE A 172
VAL A 280
ALA A 129
SER A 104
GLY A 273
 None
None
None
None
CL  A 501 ( 3.7A)
 1.13A 1nbiA-4y7dA:
2.6		 1nbiA-4y7dA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Nakamurella
multipartita) 		5 / 12 ILE A 172
VAL A 280
ALA A 129
SER A 104
GLY A 273
 None
None
None
None
CL  A 501 ( 3.7A)
 1.13A 1nbiB-4y7dA:
undetectable		 1nbiB-4y7dA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Nakamurella
multipartita) 		5 / 12 ALA A 129
LEU A 295
GLY A 105
PHE A 224
LEU A 101
 None
 1.23A 1qabF-4y7dA:
undetectable		 1qabF-4y7dA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_1
(DIPEPTIDYL PEPTIDASE
IV)		 4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Nakamurella
multipartita) 		5 / 12 SER A 104
VAL A 130
TYR A 134
VAL A 250
HIS A 275
 None
 0.75A 1x70B-4y7dA:
undetectable		 1x70B-4y7dA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RGU_A_356A901_1
(DIPEPTIDYL PEPTIDASE
4)		 4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Nakamurella
multipartita) 		5 / 12 SER A 104
VAL A 130
TYR A 134
VAL A 250
HIS A 275
 None
 0.77A 2rguA-4y7dA:
5.7		 2rguA-4y7dA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RGU_A_356A901_1
(DIPEPTIDYL PEPTIDASE
4)		 4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Nakamurella
multipartita) 		5 / 12 TRP A 103
VAL A 130
TYR A 134
VAL A 250
HIS A 275
 None
 1.21A 2rguA-4y7dA:
5.7		 2rguA-4y7dA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RGU_B_356B902_1
(DIPEPTIDYL PEPTIDASE
4)		 4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Nakamurella
multipartita) 		5 / 11 SER A 104
VAL A 130
TYR A 134
VAL A 250
HIS A 275
 None
 0.71A 2rguB-4y7dA:
12.5		 2rguB-4y7dA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RGU_B_356B902_1
(DIPEPTIDYL PEPTIDASE
4)		 4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Nakamurella
multipartita) 		5 / 11 TRP A 103
VAL A 130
TYR A 134
VAL A 250
HIS A 275
 None
 1.22A 2rguB-4y7dA:
12.5		 2rguB-4y7dA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Nakamurella
multipartita) 		5 / 11 LEU A 124
VAL A 100
GLY A  99
ILE A 235
ALA A 114
 None
 0.77A 2yy8A-4y7dA:
undetectable
2yy8B-4y7dA:
undetectable		 2yy8A-4y7dA:
20.59
2yy8B-4y7dA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_A_BJMA1_1
(DIPEPTIDYL PEPTIDASE
4)		 4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Nakamurella
multipartita) 		5 / 12 SER A 104
VAL A 130
TYR A 134
VAL A 250
HIS A 275
 None
 0.68A 3bjmA-4y7dA:
5.5		 3bjmA-4y7dA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_B_BJMB2_1
(DIPEPTIDYL PEPTIDASE
4)		 4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Nakamurella
multipartita) 		5 / 12 SER A 104
VAL A 130
TYR A 134
VAL A 250
HIS A 275
 None
 0.72A 3bjmB-4y7dA:
7.1		 3bjmB-4y7dA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_A_T22A800_1
(DIPEPTIDYL PEPTIDASE
4)		 4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Nakamurella
multipartita) 		5 / 12 SER A 104
VAL A 130
TYR A 134
VAL A 250
HIS A 275
 None
 0.84A 3g0bA-4y7dA:
15.4		 3g0bA-4y7dA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_B_T22B800_1
(DIPEPTIDYL PEPTIDASE
4)		 4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Nakamurella
multipartita) 		5 / 12 SER A 104
VAL A 130
TYR A 134
VAL A 250
HIS A 275
 None
 0.85A 3g0bB-4y7dA:
13.5		 3g0bB-4y7dA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_D_T22D800_1
(DIPEPTIDYL PEPTIDASE
4)		 4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Nakamurella
multipartita) 		5 / 12 SER A 104
VAL A 130
TYR A 134
VAL A 250
HIS A 275
 None
 0.85A 3g0bD-4y7dA:
5.6		 3g0bD-4y7dA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Nakamurella
multipartita) 		4 / 7 VAL A 100
VAL A 241
ILE A 235
ARG A  65
 None
 1.01A 3ms9B-4y7dA:
undetectable		 3ms9B-4y7dA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Nakamurella
multipartita) 		5 / 12 GLY A 148
THR A 149
LEU A 151
ASP A 137
GLY A 141
 None
 1.06A 3sglA-4y7dA:
undetectable		 3sglA-4y7dA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Nakamurella
multipartita) 		5 / 12 VAL A 250
HIS A 275
ASP A 247
GLY A  38
SER A 104
 None
 0.82A 3sufB-4y7dA:
undetectable		 3sufB-4y7dA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Nakamurella
multipartita) 		4 / 7 ARG A  59
ALA A  60
ILE A  61
GLY A  99
 None
 0.89A 3v4tH-4y7dA:
undetectable		 3v4tH-4y7dA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_A_LF7A801_1
(DIPEPTIDYL PEPTIDASE
4)		 4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Nakamurella
multipartita) 		5 / 12 SER A 104
VAL A 130
TYR A 134
VAL A 250
HIS A 275
 None
 0.59A 3w2tA-4y7dA:
13.8		 3w2tA-4y7dA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Nakamurella
multipartita) 		5 / 12 SER A 104
VAL A 130
TYR A 134
VAL A 250
HIS A 275
 None
 0.62A 3w2tB-4y7dA:
8.0		 3w2tB-4y7dA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Nakamurella
multipartita) 		3 / 3 ASP A 193
ARG A 288
LYS A 196
 None
 1.15A 3wipG-4y7dA:
undetectable		 3wipG-4y7dA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Nakamurella
multipartita) 		5 / 12 SER A 104
VAL A 130
TYR A 134
VAL A 250
HIS A 275
 None
 0.77A 4ffwA-4y7dA:
5.4		 4ffwA-4y7dA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		 4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Nakamurella
multipartita) 		5 / 12 SER A 104
VAL A 130
TYR A 134
VAL A 250
HIS A 275
 None
 0.73A 4ffwB-4y7dA:
6.2		 4ffwB-4y7dA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_1
(MEMBRANE LIPOPROTEIN
TPN38(B))		 4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Nakamurella
multipartita) 		5 / 12 SER A 206
TRP A 279
ALA A 128
ASP A 249
GLY A  41
 None
 1.15A 4iilA-4y7dA:
2.9		 4iilA-4y7dA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Nakamurella
multipartita) 		4 / 6 SER A 110
GLY A  42
ASP A  64
GLY A  46
 None
 0.88A 4koeA-4y7dA:
undetectable
4koeB-4y7dA:
undetectable
4koeC-4y7dA:
3.3		 4koeA-4y7dA:
20.56
4koeB-4y7dA:
20.56
4koeC-4y7dA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Nakamurella
multipartita) 		4 / 7 SER A 110
GLY A  42
ASP A  64
GLY A  46
 None
 0.85A 4koeA-4y7dA:
undetectable
4koeB-4y7dA:
undetectable
4koeD-4y7dA:
3.2		 4koeA-4y7dA:
20.56
4koeB-4y7dA:
20.56
4koeD-4y7dA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Nakamurella
multipartita) 		5 / 10 GLY A  99
VAL A 100
THR A 239
VAL A 121
SER A 110
 None
 1.09A 4yb6A-4y7dA:
undetectable
4yb6E-4y7dA:
undetectable		 4yb6A-4y7dA:
20.94
4yb6E-4y7dA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Nakamurella
multipartita) 		5 / 10 GLY A  99
VAL A 100
THR A 239
VAL A 121
SER A 110
 None
 1.09A 4yb6B-4y7dA:
undetectable
4yb6C-4y7dA:
undetectable		 4yb6B-4y7dA:
20.94
4yb6C-4y7dA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Nakamurella
multipartita) 		5 / 10 GLY A  99
VAL A 100
THR A 239
VAL A 121
SER A 110
 None
 1.12A 4yb6C-4y7dA:
undetectable
4yb6F-4y7dA:
undetectable		 4yb6C-4y7dA:
20.94
4yb6F-4y7dA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Nakamurella
multipartita) 		5 / 10 SER A 110
GLY A  99
VAL A 100
THR A 239
VAL A 121
 None
 1.12A 4yb6A-4y7dA:
undetectable
4yb6D-4y7dA:
undetectable		 4yb6A-4y7dA:
20.94
4yb6D-4y7dA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Nakamurella
multipartita) 		5 / 10 SER A 110
GLY A  99
VAL A 100
THR A 239
VAL A 121
 None
 1.14A 4yb6D-4y7dA:
undetectable
4yb6E-4y7dA:
undetectable		 4yb6D-4y7dA:
20.94
4yb6E-4y7dA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Nakamurella
multipartita) 		5 / 10 SER A 110
GLY A  99
VAL A 100
THR A 239
VAL A 121
 None
 1.09A 4yb6B-4y7dA:
undetectable
4yb6F-4y7dA:
undetectable		 4yb6B-4y7dA:
20.94
4yb6F-4y7dA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Nakamurella
multipartita) 		4 / 6 GLY A  42
ASP A  64
GLY A  46
SER A 110
 None
 0.83A 4z53A-4y7dA:
2.9
4z53B-4y7dA:
1.8		 4z53A-4y7dA:
15.50
4z53B-4y7dA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Nakamurella
multipartita) 		4 / 7 GLY A  42
ASP A  64
GLY A  46
SER A 110
 None
 0.80A 4z53A-4y7dA:
2.9
4z53B-4y7dA:
1.8		 4z53A-4y7dA:
15.50
4z53B-4y7dA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Nakamurella
multipartita) 		4 / 6 TYR A  68
TYR A  86
GLY A 105
ASP A 249
 None
 1.31A 5emlA-4y7dA:
undetectable		 5emlA-4y7dA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Nakamurella
multipartita) 		3 / 3 VAL A 100
HIS A  37
VAL A  63
 None
 0.59A 5jmnC-4y7dA:
undetectable		 5jmnC-4y7dA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Nakamurella
multipartita) 		4 / 7 GLY A  46
HIS A  37
ASP A  64
ASP A  44
 None
 1.08A 5no9D-4y7dA:
undetectable		 5no9D-4y7dA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Nakamurella
multipartita) 		5 / 12 ALA A  60
GLY A  99
ASP A  44
GLY A  42
LEU A 203
 None
 1.15A 5wwsA-4y7dA:
undetectable		 5wwsA-4y7dA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Nakamurella
multipartita) 		5 / 10 ILE A  61
ILE A 235
ALA A 114
LEU A 113
ALA A  83
 None
 1.49A 5zjiB-4y7dA:
undetectable		 5zjiB-4y7dA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B1E_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Nakamurella
multipartita) 		5 / 12 SER A 104
VAL A 130
TYR A 134
VAL A 250
HIS A 275
 None
 0.62A 6b1eB-4y7dA:
13.0		 6b1eB-4y7dA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Nakamurella
multipartita) 		5 / 12 TYR A  68
SER A 109
GLN A  82
VAL A  36
ASP A  23
 None
 1.25A 6bxlB-4y7dA:
1.9		 6bxlB-4y7dA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Nakamurella
multipartita) 		4 / 5 GLN A 189
VAL A 187
PRO A 282
THR A 171
 None
 1.46A 6cduA-4y7dA:
undetectable
6cduB-4y7dA:
undetectable		 6cduA-4y7dA:
23.03
6cduB-4y7dA:
23.03