SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y7i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 4y7i MYOTUBULARIN-RELATED
PROTEIN 8
(Homo
sapiens) 		5 / 12 TYR A 475
TYR A 360
LEU A 366
LEU A 369
ILE A 406
 None
 1.41A 1fmlA-4y7iA:
undetectable		 1fmlA-4y7iA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4y7i MYOTUBULARIN-RELATED
PROTEIN 8
(Homo
sapiens) 		4 / 5 ARG A 242
ASP A 219
SER A 179
SER A 210
 PO4  A 601 (-4.8A)
None
None
None
 1.45A 1kiaB-4y7iA:
undetectable		 1kiaB-4y7iA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4y7i MYOTUBULARIN-RELATED
PROTEIN 8
(Homo
sapiens) 		4 / 6 ARG A 242
ASP A 219
SER A 179
SER A 210
 PO4  A 601 (-4.8A)
None
None
None
 1.44A 1kiaC-4y7iA:
undetectable		 1kiaC-4y7iA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 4y7i MYOTUBULARIN-RELATED
PROTEIN 8
(Homo
sapiens) 		4 / 6 GLY A 441
PHE A 381
SER A 382
ARG A 447
 None
 1.37A 2a3cB-4y7iA:
undetectable		 2a3cB-4y7iA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 4y7i MYOTUBULARIN-RELATED
PROTEIN 8
(Homo
sapiens) 		5 / 11 GLY A 341
ILE A 273
ALA A 315
VAL A 348
ILE A 323
 PO4  A 602 (-3.7A)
None
None
None
None
 1.11A 2nnhA-4y7iA:
undetectable		 2nnhA-4y7iA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4y7i MYOTUBULARIN-RELATED
PROTEIN 8
(Homo
sapiens) 		4 / 5 LEU A 335
ALA A 201
ILE A 202
SER A 192
 None
 1.04A 2othA-4y7iA:
undetectable		 2othA-4y7iA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4y7i MYOTUBULARIN-RELATED
PROTEIN 8
(Homo
sapiens) 		5 / 12 LEU A 223
ILE A 323
PRO A 168
VAL A 171
TRP A 146
 None
 0.99A 2po7B-4y7iA:
undetectable		 2po7B-4y7iA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 4y7i MYOTUBULARIN-RELATED
PROTEIN 8
(Homo
sapiens) 		3 / 3 ARG A 183
ASN A 275
THR A 241
 None
PO4  A 601 (-4.5A)
None
 0.65A 2q63A-4y7iA:
undetectable		 2q63A-4y7iA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 4y7i MYOTUBULARIN-RELATED
PROTEIN 8
(Homo
sapiens) 		4 / 8 ASP A 449
LEU A 450
GLY A 441
TYR A 453
 None
 1.03A 3af0A-4y7iA:
undetectable		 3af0A-4y7iA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 4y7i MYOTUBULARIN-RELATED
PROTEIN 8
(Homo
sapiens) 		4 / 8 GLU A 373
TYR A 360
SER A 134
ILE A 130
 None
 1.04A 3jz0B-4y7iA:
undetectable		 3jz0B-4y7iA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4y7i MYOTUBULARIN-RELATED
PROTEIN 8
(Homo
sapiens) 		4 / 6 GLN A 401
MET A 279
ILE A 398
SER A 350
 None
 1.14A 3pmzD-4y7iA:
undetectable		 3pmzD-4y7iA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4y7i MYOTUBULARIN-RELATED
PROTEIN 8
(Homo
sapiens) 		5 / 12 GLY A 365
VAL A 483
PHE A 417
ILE A 354
PHE A 419
 None
 1.25A 4fglA-4y7iA:
undetectable
4fglB-4y7iA:
undetectable		 4fglA-4y7iA:
20.43
4fglB-4y7iA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4y7i MYOTUBULARIN-RELATED
PROTEIN 8
(Homo
sapiens) 		4 / 7 VAL A 459
TRP A 460
ILE A 375
LEU A 403
 None
 1.17A 4xo7B-4y7iA:
undetectable		 4xo7B-4y7iA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA406_0
(PROTON-GATED ION
CHANNEL)		 4y7i MYOTUBULARIN-RELATED
PROTEIN 8
(Homo
sapiens) 		4 / 4 LEU A 223
ILE A 266
ARG A 183
TYR A 263
 None
 1.43A 4zzcA-4y7iA:
undetectable		 4zzcA-4y7iA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB406_0
(PROTON-GATED ION
CHANNEL)		 4y7i MYOTUBULARIN-RELATED
PROTEIN 8
(Homo
sapiens) 		4 / 4 LEU A 223
ILE A 266
ARG A 183
TYR A 263
 None
 1.47A 4zzcB-4y7iA:
undetectable		 4zzcB-4y7iA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 4y7i MYOTUBULARIN-RELATED
PROTEIN 8
(Homo
sapiens) 		3 / 3 VAL A 336
GLN A 347
CYH A 349
 None
 0.70A 5icxA-4y7iA:
undetectable
5icxE-4y7iA:
undetectable		 5icxA-4y7iA:
19.63
5icxE-4y7iA:
5.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4y7i MYOTUBULARIN-RELATED
PROTEIN 8
(Homo
sapiens) 		4 / 5 ILE A 375
ILE A 427
HIS A 428
VAL A 431
 None
 1.04A 5jmnA-4y7iA:
undetectable		 5jmnA-4y7iA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4y7i MYOTUBULARIN-RELATED
PROTEIN 8
(Homo
sapiens) 		4 / 5 ILE A 375
ILE A 427
HIS A 430
VAL A 459
 None
 0.87A 5jmnA-4y7iA:
undetectable		 5jmnA-4y7iA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4y7i MYOTUBULARIN-RELATED
PROTEIN 8
(Homo
sapiens) 		4 / 5 ILE A 375
LEU A 366
HIS A 428
VAL A 431
 None
 0.98A 5jmnB-4y7iA:
1.3		 5jmnB-4y7iA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4y7i MYOTUBULARIN-RELATED
PROTEIN 8
(Homo
sapiens) 		4 / 5 ILE A 375
LEU A 403
HIS A 430
VAL A 459
 None
 0.93A 5jmnB-4y7iA:
1.3		 5jmnB-4y7iA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 4y7i MYOTUBULARIN-RELATED
PROTEIN 8
(Homo
sapiens) 		3 / 3 TYR A 453
TYR A 155
GLN A 444
 None
 1.13A 5jsdA-4y7iA:
undetectable
5jsdB-4y7iA:
undetectable		 5jsdA-4y7iA:
18.85
5jsdB-4y7iA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 4y7i MYOTUBULARIN-RELATED
PROTEIN 8
(Homo
sapiens) 		3 / 3 TYR A 453
TYR A 155
GLN A 444
 None
 1.13A 5jsdB-4y7iA:
undetectable
5jsdC-4y7iA:
undetectable		 5jsdB-4y7iA:
18.85
5jsdC-4y7iA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 4y7i MYOTUBULARIN-RELATED
PROTEIN 8
(Homo
sapiens) 		4 / 5 HIS A 379
GLU A 371
LEU A 450
VAL A 452
 None
 1.19A 6bc9A-4y7iA:
undetectable		 6bc9A-4y7iA:
12.76