SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y7k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4y7k LARGE CONDUCTANCE
MECHANOSENSITIVE
CHANNEL
PROTEIN,RIBOFLAVIN
SYNTHASE
(Methanocaldococc
us
jannaschii;
Methanosarcina
acetivorans) 		5 / 11 SER A 180
LEU A 144
ILE A 106
ILE A 195
VAL A 160
 None
 1.15A 1pkvA-4y7kA:
undetectable
1pkvB-4y7kA:
undetectable		 1pkvA-4y7kA:
15.75
1pkvB-4y7kA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 4y7k LARGE CONDUCTANCE
MECHANOSENSITIVE
CHANNEL
PROTEIN,RIBOFLAVIN
SYNTHASE
(Methanocaldococc
us
jannaschii;
Methanosarcina
acetivorans) 		5 / 12 ALA A  84
ILE A  21
ALA A  22
MET A  25
GLY A  26
 None
 0.91A 4r29D-4y7kA:
undetectable		 4r29D-4y7kA:
19.72