SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y7l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)		 4y7l TYPE VI SECRETION
PROTEIN ICMF
(Escherichia
coli) 		3 / 3 TRP A 887
ALA A 882
VAL A 884
 None
 0.89A 1c4dC-4y7lA:
undetectable
1c4dD-4y7lA:
undetectable		 1c4dC-4y7lA:
4.89
1c4dD-4y7lA:
4.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)		 4y7l TYPE VI SECRETION
PROTEIN ICMF
(Escherichia
coli) 		3 / 3 ALA A 882
VAL A 884
TRP A 887
 None
 0.69A 1tkqB-4y7lA:
undetectable		 1tkqB-4y7lA:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 4y7l TYPE VI SECRETION
PROTEIN ICMF
(Escherichia
coli) 		4 / 6 TRP A1010
LEU A 994
ARG A 982
GLY A 984
 None
 1.07A 2hs2B-4y7lA:
undetectable		 2hs2B-4y7lA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 4y7l TYPE VI SECRETION
PROTEIN ICMF
(Escherichia
coli) 		4 / 6 ARG A 938
ILE A 965
LEU A1096
GLU A1088
 None
 0.89A 2ya7A-4y7lA:
2.0		 2ya7A-4y7lA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 4y7l TYPE VI SECRETION
PROTEIN ICMF
(Escherichia
coli) 		4 / 6 ARG A 938
ILE A 965
LEU A1096
GLU A1088
 None
 0.90A 2ya7B-4y7lA:
undetectable		 2ya7B-4y7lA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 4y7l TYPE VI SECRETION
PROTEIN ICMF
(Escherichia
coli) 		4 / 6 ARG A 938
ILE A 965
LEU A1096
GLU A1088
 None
 0.89A 2ya7D-4y7lA:
undetectable		 2ya7D-4y7lA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_B_SALB1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4y7l TYPE VI SECRETION
PROTEIN ICMF
(Escherichia
coli) 		5 / 9 ARG A 880
THR A1104
VAL A1105
LEU A 875
ALA A 877
 None
 1.46A 3ax7B-4y7lA:
undetectable		 3ax7B-4y7lA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 4y7l TYPE VI SECRETION
PROTEIN ICMF
(Escherichia
coli) 		3 / 3 THR A1031
SER A1030
ARG A1076
 None
 0.70A 3phnA-4y7lA:
undetectable		 3phnA-4y7lA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 4y7l TYPE VI SECRETION
PROTEIN ICMF
(Escherichia
coli) 		4 / 6 LEU A1082
TYR A1080
ARG A1056
LEU A 981
 None
 0.83A 3rd0A-4y7lA:
3.3		 3rd0A-4y7lA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4y7l TYPE VI SECRETION
PROTEIN ICMF
(Escherichia
coli) 		5 / 7 ARG A 880
THR A1104
VAL A1105
LEU A 875
ALA A 877
 None
 1.42A 3uniA-4y7lA:
undetectable		 3uniA-4y7lA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 4y7l TYPE VI SECRETION
PROTEIN ICMF
(Escherichia
coli) 		4 / 8 TRP A1045
PRO A1022
GLY A1046
ASP A 997
 None
 1.13A 5kf8A-4y7lA:
undetectable		 5kf8A-4y7lA:
22.02