SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y7m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)		 4y7m TYPE VI SECRETION
PROTEIN ICMF
(Escherichia
coli) 		3 / 3 TRP C 887
ALA C 882
VAL C 884
 None
SO4  C1201 ( 4.0A)
None
 0.90A 1c4dC-4y7mC:
undetectable
1c4dD-4y7mC:
undetectable		 1c4dC-4y7mC:
4.21
1c4dD-4y7mC:
4.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)		 4y7m TYPE VI SECRETION
PROTEIN ICMF
(Escherichia
coli) 		3 / 3 ALA C 882
VAL C 884
TRP C 887
 SO4  C1201 ( 4.0A)
None
None
 0.71A 1tkqB-4y7mC:
undetectable		 1tkqB-4y7mC:
4.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 4y7m TYPE VI SECRETION
PROTEIN ICMF
(Escherichia
coli) 		5 / 12 MET C1053
ALA C1039
THR C 996
ARG C1049
LEU C 981
 None
 1.28A 2rctA-4y7mC:
undetectable		 2rctA-4y7mC:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 4y7m TYPE VI SECRETION
PROTEIN ICMF
(Escherichia
coli) 		4 / 6 LEU C1082
TYR C1080
ARG C1056
LEU C 981
 None
 0.78A 3rd0A-4y7mC:
3.3		 3rd0A-4y7mC:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RET_A_SALA201_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 4y7m HI113 PROTEIN
(Lama
glama) 		5 / 10 ALA A  33
VAL A  99
MET A 116
TYR A 109
ILE A 104
 None
 1.32A 3retA-4y7mA:
undetectable
3retB-4y7mA:
undetectable		 3retA-4y7mA:
21.23
3retB-4y7mA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RET_B_SALB201_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 4y7m HI113 PROTEIN
(Lama
glama) 		5 / 9 ALA A  33
VAL A  99
MET A 116
TYR A 109
ILE A 104
 None
 1.36A 3retB-4y7mA:
undetectable		 3retB-4y7mA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 4y7m HI113 PROTEIN
(Lama
glama) 		3 / 3 LEU A  81
MET A  83
ASP A 108
 None
 0.63A 4j7xB-4y7mA:
undetectable		 4j7xB-4y7mA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 4y7m TYPE VI SECRETION
PROTEIN ICMF
(Escherichia
coli) 		5 / 12 ILE C 920
ALA C 958
THR C 943
VAL C 931
LEU C 924
 None
 1.40A 4qzuA-4y7mC:
undetectable		 4qzuA-4y7mC:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4y7m HI113 PROTEIN
(Lama
glama) 		4 / 7 ALA A  92
THR A  91
VAL A 125
GLU A  89
 None
 0.83A 5ecoD-4y7mA:
undetectable		 5ecoD-4y7mA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 4y7m TYPE VI SECRETION
PROTEIN ICMF
(Escherichia
coli) 		4 / 8 TRP C1045
PRO C1022
GLY C1046
ASP C 997
 None
 1.15A 5kf8A-4y7mC:
undetectable		 5kf8A-4y7mC:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4y7m TYPE VI SECRETION
PROTEIN ICMF
(Escherichia
coli) 		5 / 12 LEU C1094
LEU C 994
ARG C1049
ILE C1048
LEU C 981
 None
 1.10A 5ljeA-4y7mC:
undetectable		 5ljeA-4y7mC:
19.03