SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y7v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 4y7v NUCLEOTIDYL
TRANSFERASE
(Pseudomonas
putida) 		4 / 8 LEU A  41
THR A 110
LEU A  38
VAL A 108
 None
 0.95A 1sn5C-4y7vA:
undetectable		 1sn5C-4y7vA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4y7v NUCLEOTIDYL
TRANSFERASE
(Pseudomonas
putida) 		5 / 10 ALA A   3
LEU A  41
LEU A  72
ILE A  34
LEU A  64
 None
 1.15A 3fl9E-4y7vA:
undetectable		 3fl9E-4y7vA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 4y7v NUCLEOTIDYL
TRANSFERASE
(Pseudomonas
putida) 		5 / 10 GLY A  67
ALA A   7
ILE A  34
LEU A  64
LEU A  38
 None
 1.14A 4xj7A-4y7vA:
2.7
4xj7B-4y7vA:
2.7		 4xj7A-4y7vA:
22.79
4xj7B-4y7vA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 4y7v NUCLEOTIDYL
TRANSFERASE
(Pseudomonas
putida) 		6 / 10 LEU A  64
LEU A  38
GLY A  67
SER A  73
ALA A   7
ILE A  34
 None
 1.37A 4xj7C-4y7vA:
3.0
4xj7D-4y7vA:
3.0		 4xj7C-4y7vA:
22.79
4xj7D-4y7vA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 4y7v NUCLEOTIDYL
TRANSFERASE
(Pseudomonas
putida) 		5 / 9 VAL A  49
LEU A  41
PHE A 114
VAL A 104
ILE A   5
 None
 1.15A 5om2A-4y7vA:
undetectable
5om2B-4y7vA:
undetectable		 5om2A-4y7vA:
16.88
5om2B-4y7vA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)		 4y7v NUCLEOTIDYL
TRANSFERASE
(Pseudomonas
putida) 		4 / 8 GLY A  67
ILE A  74
ASP A  62
HIS A  63
 None
 1.06A 6ag0C-4y7vA:
undetectable		 6ag0C-4y7vA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 4y7v NUCLEOTIDYL
TRANSFERASE
(Pseudomonas
putida) 		4 / 4 ILE A  89
LEU A 185
HIS A 167
ALA A 125
 None
 1.01A 6ck2C-4y7vA:
undetectable
6ck2D-4y7vA:
undetectable		 6ck2C-4y7vA:
8.45
6ck2D-4y7vA:
14.39