SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y81'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_2
(PROTEIN (PROTEASE))		 4y81 PROTEASOME SUBUNIT
BETA TYPE-6
(Saccharomyces
cerevisiae) 		5 / 12 ARG L 213
VAL L  43
ILE L  12
GLY L  14
ILE L  15
 None
 0.98A 1c6zB-4y81L:
undetectable		 1c6zB-4y81L:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 4y81 PROTEASOME SUBUNIT
BETA TYPE-6
(Saccharomyces
cerevisiae) 		5 / 10 ALA L 191
HIS L 195
LEU L 145
ALA L 142
GLY L 140
 None
 1.30A 1mjqG-4y81L:
undetectable
1mjqH-4y81L:
undetectable		 1mjqG-4y81L:
16.44
1mjqH-4y81L:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 4y81 PROTEASOME SUBUNIT
BETA TYPE-6
(Saccharomyces
cerevisiae) 		4 / 4 ILE L 111
PHE L  68
ILE L  50
THR L 109
 None
 1.00A 3ia4A-4y81L:
undetectable		 3ia4A-4y81L:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 4y81 PROTEASOME SUBUNIT
BETA TYPE-6
(Saccharomyces
cerevisiae) 		5 / 12 LEU L 205
LEU L  84
GLY L 113
ILE L 111
ALA L  90
 None
 1.02A 3uwlB-4y81L:
undetectable		 3uwlB-4y81L:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 4y81 PROTEASOME SUBUNIT
BETA TYPE-6
(Saccharomyces
cerevisiae) 		5 / 12 LEU L 205
LEU L  84
GLY L 113
ILE L 111
ALA L  90
 None
 1.03A 3uwlD-4y81L:
undetectable		 3uwlD-4y81L:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)		 4y81 PROTEASOME SUBUNIT
BETA TYPE-6
(Saccharomyces
cerevisiae) 		5 / 9 ARG L 213
VAL L  43
ILE L  12
GLY L  14
ILE L  15
 None
 1.12A 5kqxB-4y81L:
undetectable		 5kqxB-4y81L:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 4y81 PROTEASOME SUBUNIT
BETA TYPE-6
(Saccharomyces
cerevisiae) 		5 / 12 ARG L 137
GLY L 140
GLY L  10
GLU L 203
LEU L 205
 None
 1.09A 5ul4A-4y81L:
undetectable		 5ul4A-4y81L:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4y81 PROTEASOME SUBUNIT
BETA TYPE-6
(Saccharomyces
cerevisiae) 		3 / 3 GLU L 218
TYR L 217
ARG L 185
 None
 0.78A 5uunB-4y81L:
undetectable		 5uunB-4y81L:
21.86