SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y85'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4y85 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 8
(Homo
sapiens) 		5 / 12 PHE A 271
LEU A 268
VAL A 237
ALA A 380
ALA A 379
 None
 1.32A 1q23A-4y85A:
undetectable
1q23B-4y85A:
undetectable		 1q23A-4y85A:
20.80
1q23B-4y85A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 4y85 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 8
(Homo
sapiens) 		4 / 4 LEU A 193
PRO A 116
ILE A 108
LEU A 110
 None
 1.15A 1ya4C-4y85A:
undetectable		 1ya4C-4y85A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 4y85 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 8
(Homo
sapiens) 		5 / 12 PHE A 271
ALA A 196
ASN A 111
ILE A 181
ILE A 190
 None
 1.28A 2bjfA-4y85A:
undetectable		 2bjfA-4y85A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 4y85 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 8
(Homo
sapiens) 		5 / 12 PHE A 271
ALA A 196
ASN A 111
ILE A 190
LEU A 110
 None
 1.25A 2bjfA-4y85A:
undetectable		 2bjfA-4y85A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4y85 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 8
(Homo
sapiens) 		4 / 5 LEU A 313
ILE A 259
GLY A 240
HIS A 245
 None
 0.91A 2otfA-4y85A:
undetectable		 2otfA-4y85A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)		 4y85 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 8
(Homo
sapiens) 		4 / 8 MET A 207
GLY A 210
PRO A 145
GLY A 147
 499  A 401 ( 3.7A)
499  A 401 (-3.4A)
499  A 401 (-4.2A)
499  A 401 (-3.3A)
 0.77A 2y6rB-4y85A:
undetectable		 2y6rB-4y85A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OSH_A_OINA5811_1
(PHOSPHOLIPASE A2
ISOFORM 3)		 4y85 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 8
(Homo
sapiens) 		5 / 9 PHE A 271
ILE A 181
GLY A 240
LYS A 239
HIS A 251
 None
 1.45A 3oshA-4y85A:
undetectable		 3oshA-4y85A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTV_A_ADNA403_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4y85 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 8
(Homo
sapiens) 		5 / 12 HIS A 245
ASP A 309
SER A 274
ILE A 190
ILE A 181
 None
 1.46A 4ktvA-4y85A:
undetectable
4ktvB-4y85A:
undetectable		 4ktvA-4y85A:
23.53
4ktvB-4y85A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		 4y85 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 8
(Homo
sapiens) 		6 / 12 VAL A 249
LEU A 273
ILE A 181
GLN A 182
ILE A 190
ALA A 191
 None
None
None
None
None
499  A 401 ( 4.6A)
 1.35A 4ltwA-4y85A:
undetectable		 4ltwA-4y85A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4y85 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 8
(Homo
sapiens) 		5 / 8 GLY A 147
VAL A 152
ALA A 165
ASN A 258
ASP A 270
 499  A 401 (-3.3A)
499  A 401 (-4.6A)
499  A 401 (-3.2A)
499  A 401 ( 4.8A)
499  A 401 (-3.7A)
 0.60A 4ogrA-4y85A:
26.9		 4ogrA-4y85A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)		 4y85 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 8
(Homo
sapiens) 		4 / 5 GLN A 346
HIS A 344
ILE A 342
TYR A 331
 None
 1.26A 5dnvA-4y85A:
undetectable		 5dnvA-4y85A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 4y85 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 8
(Homo
sapiens) 		4 / 6 LYS A 167
SER A 214
VAL A 260
ASP A 270
 499  A 401 (-2.8A)
499  A 401 (-3.7A)
499  A 401 (-4.6A)
499  A 401 (-3.7A)
 0.69A 5hesA-4y85A:
7.7		 5hesA-4y85A:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)		 4y85 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 8
(Homo
sapiens) 		5 / 12 SER A  92
ILE A 169
LEU A 205
ALA A  88
LEU A  84
 None
 1.28A 5zwrB-4y85A:
undetectable		 5zwrB-4y85A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 4y85 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 8
(Homo
sapiens) 		3 / 3 ALA A 183
PHE A 185
GLN A 276
 None
 0.79A 6eceA-4y85A:
undetectable		 6eceA-4y85A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_ACTA405_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4y85 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 8
(Homo
sapiens) 		4 / 6 ARG A 330
PRO A 332
ARG A 333
ILE A 342
 None
 1.36A 6ef6A-4y85A:
6.4		 6ef6A-4y85A:
21.97