SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y8d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ECO_D_LEUD602_0 (JASMONIC ACID-AMIDO SYNTHETASE JAR1)	4y8d	NANOBODY (Lama glama)	4 / 7	ALA C 89 THR C 88 VAL C 117 GLU C 86	None	0.80A	5ecoD-4y8dC: undetectable	5ecoD-4y8dC: 13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5N0X_B_SAMB501_1 (PEPTIDE N-METHYLTRANSFERASE)	4y8d	NANOBODY (Lama glama)	3 / 3	SER C 25 ALA C 24 THR C 95	None	0.68A	5n0xB-4y8dC: undetectable	5n0xB-4y8dC: 14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AWO_A_SREA701_1 (SODIUM-DEPENDENT SEROTONIN TRANSPORTER)	4y8d	NANOBODY (Lama glama)	5 / 9	ALA C 101 PHE C 34 GLY C 32 PHE C 102 SER C 58	None	1.31A	6awoA-4y8dC: undetectable	6awoA-4y8dC: 14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AWQ_A_SREA701_1 (SODIUM-DEPENDENT SEROTONIN TRANSPORTER)	4y8d	NANOBODY (Lama glama)	5 / 9	ALA C 101 PHE C 34 GLY C 32 PHE C 102 SER C 58	None	1.32A	6awqA-4y8dC: undetectable	6awqA-4y8dC: 14.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6CJK_B_ACTB302_0 (IMMUNOGLOBULIN FAB HEAVY CHAIN)	4y8d	NANOBODY (Lama glama)	3 / 3	TYR C 57 GLY C 63 THR C 66	None EDO C 202 (-4.3A) EDO C 202 (-4.0A)	0.16A	6cjkB-4y8dC: 17.8	6cjkB-4y8dC: 32.74

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["5ECO_D_LEUD602_0","JASMONIC ACID-AMIDO SYNTHETASE JAR1","4y8d","NANOBODY","Lama glama",4,"ALA C  89;THR C  88;VAL C 117;GLU C  86","None","0.80A","5ecoD-4y8dC:undetectable","5ecoD-4y8dC:13.31"],["5N0X_B_SAMB501_1","PEPTIDE N-METHYLTRANSFERASE","4y8d","NANOBODY","Lama glama",3,"SER C  25;ALA C  24;THR C  95","None","0.68A","5n0xB-4y8dC:undetectable","5n0xB-4y8dC:14.56"],["6AWO_A_SREA701_1","SODIUM-DEPENDENT SEROTONIN TRANSPORTER","4y8d","NANOBODY","Lama glama",5,"ALA C 101;PHE C  34;GLY C  32;PHE C 102;SER C  58","None","1.31A","6awoA-4y8dC:undetectable","6awoA-4y8dC:14.71"],["6AWQ_A_SREA701_1","SODIUM-DEPENDENT SEROTONIN TRANSPORTER","4y8d","NANOBODY","Lama glama",5,"ALA C 101;PHE C  34;GLY C  32;PHE C 102;SER C  58","None","1.32A","6awqA-4y8dC:undetectable","6awqA-4y8dC:14.71"],["6CJK_B_ACTB302_0","IMMUNOGLOBULIN FAB HEAVY CHAIN","4y8d","NANOBODY","Lama glama",3,"TYR C  57;GLY C  63;THR C  66","None;EDO C 202 (-4.3A);EDO C 202 (-4.0A)","0.16A","6cjkB-4y8dC:17.8","6cjkB-4y8dC:32.74"]]