SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y8f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3003_1
(SERUM ALBUMIN)		 4y8f TRIOSEPHOSPHATE
ISOMERASE
(Clostridium
perfringens) 		3 / 4 LYS A 114
ALA A 117
MET A  68
 None
 0.95A 1hk3A-4y8fA:
undetectable		 1hk3A-4y8fA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_2
(HIV-1 PROTEASE)		 4y8f TRIOSEPHOSPHATE
ISOMERASE
(Clostridium
perfringens) 		5 / 12 GLY A  11
ALA A  10
VAL A 165
GLY A 213
ILE A 126
 None
 0.98A 1hsgB-4y8fA:
undetectable		 1hsgB-4y8fA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 4y8f TRIOSEPHOSPHATE
ISOMERASE
(Clostridium
perfringens) 		5 / 12 VAL A 196
ILE A 149
ILE A 166
ILE A 210
VAL A 204
 None
 1.05A 1qhyA-4y8fA:
undetectable		 1qhyA-4y8fA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_3
(POL POLYPROTEIN)		 4y8f TRIOSEPHOSPHATE
ISOMERASE
(Clostridium
perfringens) 		5 / 12 GLY A  11
ALA A  10
VAL A 165
GLY A 213
ILE A 126
 None
 1.03A 2avsB-4y8fA:
undetectable		 2avsB-4y8fA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 4y8f TRIOSEPHOSPHATE
ISOMERASE
(Clostridium
perfringens) 		3 / 3 SER A   2
ASP A 229
ASP A 206
 None
 0.70A 2plwA-4y8fA:
undetectable		 2plwA-4y8fA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 4y8f TRIOSEPHOSPHATE
ISOMERASE
(Clostridium
perfringens) 		3 / 3 SER A   2
ASP A 231
ASP A 206
 None
 0.76A 2plwA-4y8fA:
undetectable		 2plwA-4y8fA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 4y8f TRIOSEPHOSPHATE
ISOMERASE
(Clostridium
perfringens) 		5 / 12 ALA A 167
ALA A 233
GLY A 236
ILE A 126
HIS A  97
 None
 0.95A 2x1lB-4y8fA:
undetectable		 2x1lB-4y8fA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 4y8f TRIOSEPHOSPHATE
ISOMERASE
(Clostridium
perfringens) 		5 / 11 ALA A 167
ALA A 233
GLY A 236
ILE A 126
HIS A  97
 None
 0.97A 2x1lC-4y8fA:
undetectable		 2x1lC-4y8fA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4y8f TRIOSEPHOSPHATE
ISOMERASE
(Clostridium
perfringens) 		4 / 8 LEU A 156
GLY A 201
ALA A 205
ILE A 166
 None
 0.81A 3jusA-4y8fA:
undetectable		 3jusA-4y8fA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4y8f TRIOSEPHOSPHATE
ISOMERASE
(Clostridium
perfringens) 		4 / 8 LEU A 156
GLY A 201
ALA A 205
ILE A 166
 None
 0.81A 3jusA-4y8fA:
undetectable		 3jusA-4y8fA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA408_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 4y8f TRIOSEPHOSPHATE
ISOMERASE
(Clostridium
perfringens) 		4 / 6 TYR A  92
PRO A 125
ARG A 209
PHE A 119
 None
 1.23A 4kf9A-4y8fA:
undetectable		 4kf9A-4y8fA:
22.06