SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y90'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4y90 TRIOSEPHOSPHATE
ISOMERASE
(Deinococcus
radiodurans) 		5 / 9 LEU A 123
LEU A  43
VAL A  92
GLY A  63
ALA A  89
 None
 1.30A 1pxxB-4y90A:
undetectable		 1pxxB-4y90A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 4y90 TRIOSEPHOSPHATE
ISOMERASE
(Deinococcus
radiodurans) 		3 / 3 ASP A  48
LEU A  49
HIS A  96
 None
None
CA  A 305 (-4.3A)
 0.74A 1qknA-4y90A:
undetectable		 1qknA-4y90A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 4y90 TRIOSEPHOSPHATE
ISOMERASE
(Deinococcus
radiodurans) 		4 / 8 ARG A 203
PRO A  34
VAL A  38
GLY A  37
 None
 1.14A 2qd3A-4y90A:
undetectable		 2qd3A-4y90A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 4y90 TRIOSEPHOSPHATE
ISOMERASE
(Deinococcus
radiodurans) 		5 / 12 ALA A 162
ALA A 227
GLY A 230
ILE A 125
HIS A  96
 None
None
SO4  A 301 (-3.4A)
None
CA  A 305 (-4.3A)
 0.97A 2x1lB-4y90A:
undetectable		 2x1lB-4y90A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 4y90 TRIOSEPHOSPHATE
ISOMERASE
(Deinococcus
radiodurans) 		6 / 11 ALA A 162
ALA A 227
GLY A 230
GLU A 164
ILE A 125
HIS A  96
 None
None
SO4  A 301 (-3.4A)
CA  A 305 (-3.1A)
None
CA  A 305 (-4.3A)
 1.12A 2x1lC-4y90A:
undetectable		 2x1lC-4y90A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4y90 TRIOSEPHOSPHATE
ISOMERASE
(Deinococcus
radiodurans) 		4 / 5 LEU A 183
GLN A 143
THR A 144
GLU A 182
 None
None
None
GOL  A 303 (-2.4A)
 1.37A 3n58C-4y90A:
undetectable		 3n58C-4y90A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 4y90 TRIOSEPHOSPHATE
ISOMERASE
(Deinococcus
radiodurans) 		4 / 8 GLY A 226
TYR A 206
ALA A 162
GLU A 164
 None
None
None
CA  A 305 (-3.1A)
 0.88A 3u9hA-4y90A:
undetectable		 3u9hA-4y90A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 4y90 TRIOSEPHOSPHATE
ISOMERASE
(Deinococcus
radiodurans) 		4 / 8 GLY A 226
TYR A 206
ALA A 162
GLU A 164
 None
None
None
CA  A 305 (-3.1A)
 0.84A 3u9hB-4y90A:
undetectable		 3u9hB-4y90A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 4y90 TRIOSEPHOSPHATE
ISOMERASE
(Deinococcus
radiodurans) 		4 / 5 ASP A 178
THR A 176
GLU A 217
LYS A 221
 None
 1.22A 4a3pA-4y90A:
undetectable		 4a3pA-4y90A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 4y90 TRIOSEPHOSPHATE
ISOMERASE
(Deinococcus
radiodurans) 		4 / 7 ILE A 125
LEU A 123
LYS A   4
GLY A 201
 None
 0.84A 4hc3A-4y90A:
undetectable		 4hc3A-4y90A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 4y90 TRIOSEPHOSPHATE
ISOMERASE
(Deinococcus
radiodurans) 		3 / 3 HIS A  96
GLY A 208
ILE A 169
 CA  A 305 (-4.3A)
SO4  A 301 ( 3.9A)
SO4  A 301 (-4.8A)
 0.64A 4k50A-4y90A:
undetectable		 4k50A-4y90A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 4y90 TRIOSEPHOSPHATE
ISOMERASE
(Deinococcus
radiodurans) 		3 / 3 HIS A  96
GLY A 208
ILE A 169
 CA  A 305 (-4.3A)
SO4  A 301 ( 3.9A)
SO4  A 301 (-4.8A)
 0.63A 4k50I-4y90A:
undetectable		 4k50I-4y90A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4y90 TRIOSEPHOSPHATE
ISOMERASE
(Deinococcus
radiodurans) 		4 / 7 LYS A  85
LEU A  84
GLY A  63
GLY A  64
 None
 0.58A 5a06B-4y90A:
undetectable		 5a06B-4y90A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A211_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 4y90 TRIOSEPHOSPHATE
ISOMERASE
(Deinococcus
radiodurans) 		4 / 6 VAL A 110
LYS A 113
ALA A 114
VAL A 126
 None
 0.91A 5i8fA-4y90A:
undetectable		 5i8fA-4y90A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 4y90 TRIOSEPHOSPHATE
ISOMERASE
(Deinococcus
radiodurans) 		5 / 12 GLU A 164
LEU A 205
GLY A 230
ASN A  11
ALA A  41
 CA  A 305 (-3.1A)
None
SO4  A 301 (-3.4A)
CA  A 305 (-4.2A)
None
 1.37A 5kc4A-4y90A:
undetectable		 5kc4A-4y90A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH2_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4y90 TRIOSEPHOSPHATE
ISOMERASE
(Deinococcus
radiodurans) 		3 / 3 VAL A 161
VAL A 126
GLN A 147
 None
 0.67A 5qh2A-4y90A:
undetectable		 5qh2A-4y90A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHA_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4y90 TRIOSEPHOSPHATE
ISOMERASE
(Deinococcus
radiodurans) 		3 / 3 VAL A 161
VAL A 126
GLN A 147
 None
 0.68A 5qhaA-4y90A:
undetectable		 5qhaA-4y90A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 4y90 TRIOSEPHOSPHATE
ISOMERASE
(Deinococcus
radiodurans) 		5 / 12 GLY A 226
VAL A 224
ALA A 184
VAL A 128
ALA A 175
 None
 0.92A 5xv7A-4y90A:
undetectable		 5xv7A-4y90A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 4y90 TRIOSEPHOSPHATE
ISOMERASE
(Deinococcus
radiodurans) 		5 / 9 ALA A  81
SER A  80
ALA A  89
ALA A  46
GLY A  64
 None
 1.03A 6bklE-4y90A:
undetectable
6bklF-4y90A:
undetectable
6bklG-4y90A:
undetectable
6bklH-4y90A:
undetectable		 6bklE-4y90A:
7.29
6bklF-4y90A:
7.29
6bklG-4y90A:
7.29
6bklH-4y90A:
7.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4y90 TRIOSEPHOSPHATE
ISOMERASE
(Deinococcus
radiodurans) 		4 / 6 TYR A 163
GLN A 143
GLU A 182
ALA A 175
 None
None
GOL  A 303 (-2.4A)
None
 1.17A 6djzB-4y90A:
undetectable		 6djzB-4y90A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 4y90 TRIOSEPHOSPHATE
ISOMERASE
(Deinococcus
radiodurans) 		5 / 10 ARG A 203
VAL A 204
LEU A 145
GLY A 201
GLY A 189
 None
 1.12A 6eu9B-4y90A:
undetectable		 6eu9B-4y90A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4y90 TRIOSEPHOSPHATE
ISOMERASE
(Deinococcus
radiodurans) 		4 / 6 ARG A 192
ALA A 199
LEU A 191
ALA A 190
 None
 1.21A 6fosB-4y90A:
undetectable		 6fosB-4y90A:
16.25