SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y97'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDW_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4y97 DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 10 LEU B1408
PRO B1305
VAL B1295
PHE B1422
GLU B1402
 None
 1.46A 1fdwA-4y97B:
undetectable		 1fdwA-4y97B:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 4y97 DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		3 / 3 PRO B1305
GLU B1402
TYR B1430
 None
 0.73A 2zmbA-4y97B:
undetectable		 2zmbA-4y97B:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4y97 DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 11 LEU B1417
PHE B1296
ASP B1297
ILE B1398
ASP B1293
 None
 1.38A 4uuuA-4y97B:
undetectable
4uuuB-4y97B:
undetectable		 4uuuA-4y97B:
21.55
4uuuB-4y97B:
21.55