SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y99'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4y99 TROPONIN T, CARDIAC
MUSCLE
(Homo
sapiens) 		4 / 8 LYS B 247
LEU B 250
GLN B 251
PHE B 254
 None
 0.53A 1v54C-4y99B:
undetectable
1v54J-4y99B:
2.4		 1v54C-4y99B:
15.56
1v54J-4y99B:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4y99 TROPONIN T, CARDIAC
MUSCLE
(Homo
sapiens) 		4 / 8 LYS B 247
LEU B 250
GLN B 251
PHE B 254
 None
 0.52A 1v54P-4y99B:
undetectable
1v54W-4y99B:
2.4		 1v54P-4y99B:
15.56
1v54W-4y99B:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4y99 TROPONIN T, CARDIAC
MUSCLE
(Homo
sapiens) 		4 / 7 LYS B 247
LEU B 250
GLN B 251
PHE B 254
 None
 0.63A 1v55C-4y99B:
undetectable
1v55J-4y99B:
2.4		 1v55C-4y99B:
15.56
1v55J-4y99B:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4y99 TROPONIN T, CARDIAC
MUSCLE
(Homo
sapiens) 		4 / 8 LYS B 247
LEU B 250
GLN B 251
PHE B 254
 None
 0.54A 2dyrC-4y99B:
undetectable
2dyrJ-4y99B:
2.4		 2dyrC-4y99B:
15.56
2dyrJ-4y99B:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4y99 TROPONIN T, CARDIAC
MUSCLE
(Homo
sapiens) 		4 / 8 LYS B 247
LEU B 250
GLN B 251
PHE B 254
 None
 0.50A 2dyrP-4y99B:
undetectable
2dyrW-4y99B:
2.4		 2dyrP-4y99B:
15.56
2dyrW-4y99B:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4y99 TROPONIN T, CARDIAC
MUSCLE
(Homo
sapiens) 		4 / 7 LYS B 247
LEU B 250
GLN B 251
PHE B 254
 None
 0.59A 2dysP-4y99B:
undetectable
2dysW-4y99B:
2.4		 2dysP-4y99B:
15.56
2dysW-4y99B:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4y99 TROPONIN T, CARDIAC
MUSCLE
(Homo
sapiens) 		4 / 7 LYS B 247
LEU B 250
GLN B 251
PHE B 254
 None
 0.63A 2eijC-4y99B:
undetectable
2eijJ-4y99B:
2.4		 2eijC-4y99B:
15.56
2eijJ-4y99B:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4y99 TROPONIN T, CARDIAC
MUSCLE
(Homo
sapiens) 		4 / 8 LYS B 247
LEU B 250
GLN B 251
PHE B 254
 None
 0.53A 2eikP-4y99B:
undetectable
2eikW-4y99B:
2.4		 2eikP-4y99B:
15.56
2eikW-4y99B:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4y99 TROPONIN T, CARDIAC
MUSCLE
(Homo
sapiens) 		4 / 8 LYS B 247
LEU B 250
GLN B 251
PHE B 254
 None
 0.66A 2eilC-4y99B:
undetectable
2eilJ-4y99B:
2.4		 2eilC-4y99B:
15.56
2eilJ-4y99B:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4y99 TROPONIN T, CARDIAC
MUSCLE
(Homo
sapiens) 		4 / 7 LYS B 247
LEU B 250
GLN B 251
PHE B 254
 None
 0.68A 2eimC-4y99B:
undetectable
2eimJ-4y99B:
2.4		 2eimC-4y99B:
15.56
2eimJ-4y99B:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4y99 TROPONIN I, CARDIAC
MUSCLE
TROPONIN T, CARDIAC
MUSCLE
(Homo
sapiens) 		4 / 8 LEU C  93
LEU B 229
LYS B 232
ALA B 233
 None
None
DMS  B 301 (-2.7A)
None
 1.05A 2wekA-4y99C:
undetectable		 2wekA-4y99C:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4y99 TROPONIN T, CARDIAC
MUSCLE
TROPONIN I, CARDIAC
MUSCLE
(Homo
sapiens;
Homo
sapiens) 		4 / 6 ARG C 111
LEU B 250
GLN B 251
PHE B 254
 None
 0.99A 2zxwP-4y99C:
undetectable
2zxwW-4y99C:
3.1		 2zxwP-4y99C:
15.15
2zxwW-4y99C:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4y99 TROPONIN T, CARDIAC
MUSCLE
TROPONIN I, CARDIAC
MUSCLE
(Homo
sapiens;
Homo
sapiens) 		4 / 6 ARG C 111
LEU B 250
GLN B 251
PHE B 254
 None
 0.88A 3ag1C-4y99C:
undetectable
3ag1J-4y99C:
2.9		 3ag1C-4y99C:
15.15
3ag1J-4y99C:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4y99 TROPONIN I, CARDIAC
MUSCLE
(Homo
sapiens) 		3 / 3 LYS C  46
LYS C  40
SER C  39
 None
 1.15A 5odiA-4y99C:
undetectable		 5odiA-4y99C:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4y99 TROPONIN T, CARDIAC
MUSCLE
TROPONIN I, CARDIAC
MUSCLE
(Homo
sapiens;
Homo
sapiens) 		4 / 6 ARG C 111
LYS B 247
LEU B 250
PHE B 254
 None
 1.08A 5w97C-4y99C:
undetectable
5w97J-4y99C:
3.0		 5w97C-4y99C:
15.15
5w97J-4y99C:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 4y99 TROPONIN T, CARDIAC
MUSCLE
TROPONIN I, CARDIAC
MUSCLE
(Homo
sapiens;
Homo
sapiens) 		4 / 7 LEU B 224
LEU B 229
ALA B 233
ALA C  97
 None
 0.88A 6a7jA-4y99B:
undetectable		 6a7jA-4y99B:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 4y99 TROPONIN T, CARDIAC
MUSCLE
TROPONIN I, CARDIAC
MUSCLE
(Homo
sapiens;
Homo
sapiens) 		4 / 7 LEU C  88
LEU C  93
ALA C  97
ALA B 233
 None
 0.89A 6a7jA-4y99C:
undetectable		 6a7jA-4y99C:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4y99 TROPONIN T, CARDIAC
MUSCLE
TROPONIN I, CARDIAC
MUSCLE
(Homo
sapiens;
Homo
sapiens) 		4 / 6 ARG C 111
LYS B 247
GLN B 251
PHE B 254
 None
 1.11A 6nmpC-4y99C:
undetectable
6nmpJ-4y99C:
3.0		 6nmpC-4y99C:
15.15
6nmpJ-4y99C:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4y99 TROPONIN T, CARDIAC
MUSCLE
TROPONIN I, CARDIAC
MUSCLE
(Homo
sapiens;
Homo
sapiens) 		4 / 5 ARG C 111
LEU B 250
GLN B 251
PHE B 254
 None
 1.07A 6nmpP-4y99C:
undetectable
6nmpW-4y99C:
3.0		 6nmpP-4y99C:
15.15
6nmpW-4y99C:
14.49