SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y9a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 4y9a TRIOSEPHOSPHATE
ISOMERASE
(Streptomyces
coelicolor) 		5 / 10 LEU A 247
VAL A  47
VAL A 242
GLY A  13
LEU A  19
 None
 1.36A 1fk9A-4y9aA:
undetectable		 1fk9A-4y9aA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 4y9a TRIOSEPHOSPHATE
ISOMERASE
(Streptomyces
coelicolor) 		5 / 10 LEU A 247
VAL A  47
VAL A 242
GLY A  13
LEU A  19
 None
 1.33A 1fkoA-4y9aA:
undetectable		 1fkoA-4y9aA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		 4y9a TRIOSEPHOSPHATE
ISOMERASE
(Streptomyces
coelicolor) 		5 / 10 LEU A 247
VAL A  47
VAL A 242
GLY A  13
LEU A  19
 None
 1.40A 1ikwA-4y9aA:
undetectable		 1ikwA-4y9aA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		 4y9a TRIOSEPHOSPHATE
ISOMERASE
(Streptomyces
coelicolor) 		5 / 11 LEU A 247
VAL A  47
VAL A 242
GLY A  13
LEU A  19
 None
 1.35A 1jkhA-4y9aA:
1.4
1jkhB-4y9aA:
1.5		 1jkhA-4y9aA:
20.93
1jkhB-4y9aA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 4y9a TRIOSEPHOSPHATE
ISOMERASE
(Streptomyces
coelicolor) 		5 / 10 GLY A 220
VAL A 223
ALA A 192
ASN A 227
ILE A 237
 None
 1.03A 1likA-4y9aA:
undetectable		 1likA-4y9aA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4y9a TRIOSEPHOSPHATE
ISOMERASE
(Streptomyces
coelicolor) 		5 / 9 LEU A 247
VAL A  47
VAL A 242
GLY A  13
LEU A  19
 None
 1.47A 1lwfA-4y9aA:
undetectable		 1lwfA-4y9aA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 4y9a TRIOSEPHOSPHATE
ISOMERASE
(Streptomyces
coelicolor) 		4 / 7 VAL A  45
TYR A 175
CYH A 196
ARG A 257
 None
 1.19A 1t46A-4y9aA:
undetectable		 1t46A-4y9aA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 4y9a TRIOSEPHOSPHATE
ISOMERASE
(Streptomyces
coelicolor) 		4 / 5 ALA A  72
TYR A  99
ALA A  49
GLN A 218
 None
 1.12A 1xl6A-4y9aA:
undetectable
1xl6B-4y9aA:
undetectable		 1xl6A-4y9aA:
24.29
1xl6B-4y9aA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BPX_B_MK1B902_2
(HIV-1 PROTEASE)		 4y9a TRIOSEPHOSPHATE
ISOMERASE
(Streptomyces
coelicolor) 		6 / 12 GLY A  13
ALA A  12
VAL A 172
GLY A 220
VAL A 102
ILE A 133
 None
 1.34A 2bpxB-4y9aA:
undetectable		 2bpxB-4y9aA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HND_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4y9a TRIOSEPHOSPHATE
ISOMERASE
(Streptomyces
coelicolor) 		5 / 10 LEU A 247
VAL A  47
VAL A 242
GLY A  13
LEU A  19
 None
 1.50A 2hndA-4y9aA:
undetectable		 2hndA-4y9aA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 4y9a TRIOSEPHOSPHATE
ISOMERASE
(Streptomyces
coelicolor) 		5 / 11 ALA A 174
ALA A 240
GLY A 243
ILE A 133
HIS A 104
 None
 0.99A 2x1lA-4y9aA:
2.0		 2x1lA-4y9aA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 4y9a TRIOSEPHOSPHATE
ISOMERASE
(Streptomyces
coelicolor) 		5 / 12 ALA A 174
ALA A 240
GLY A 243
ILE A 133
HIS A 104
 None
 0.95A 2x1lB-4y9aA:
undetectable		 2x1lB-4y9aA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 4y9a TRIOSEPHOSPHATE
ISOMERASE
(Streptomyces
coelicolor) 		5 / 11 ALA A 174
ALA A 240
GLY A 243
ILE A 133
HIS A 104
 None
 0.98A 2x1lC-4y9aA:
undetectable		 2x1lC-4y9aA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 4y9a TRIOSEPHOSPHATE
ISOMERASE
(Streptomyces
coelicolor) 		5 / 12 ALA A 192
VAL A 195
GLY A 137
GLU A 176
THR A 183
 None
 0.99A 3c6gB-4y9aA:
undetectable		 3c6gB-4y9aA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 4y9a TRIOSEPHOSPHATE
ISOMERASE
(Streptomyces
coelicolor) 		5 / 12 GLY A 226
ALA A 189
ALA A 192
CYH A 196
ASP A 190
 None
 1.04A 3keeA-4y9aA:
undetectable		 3keeA-4y9aA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4y9a TRIOSEPHOSPHATE
ISOMERASE
(Streptomyces
coelicolor) 		5 / 10 LEU A 247
VAL A  47
VAL A 242
GLY A  13
LEU A  19
 None
 1.40A 3lp1A-4y9aA:
undetectable		 3lp1A-4y9aA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_B_DXCB92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4y9a TRIOSEPHOSPHATE
ISOMERASE
(Streptomyces
coelicolor) 		4 / 5 VAL A 253
VAL A 256
ARG A 257
LYS A  69
 None
 1.38A 3rv5A-4y9aA:
undetectable
3rv5B-4y9aA:
undetectable		 3rv5A-4y9aA:
16.48
3rv5B-4y9aA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_1
(ADENOSINE KINASE,
PUTATIVE)		 4y9a TRIOSEPHOSPHATE
ISOMERASE
(Streptomyces
coelicolor) 		5 / 12 ILE A  68
LEU A  35
GLY A  13
ALA A  12
GLY A  71
 None
 0.92A 3uq6B-4y9aA:
undetectable		 3uq6B-4y9aA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_D_CAMD502_0
(CAMPHOR
5-MONOOXYGENASE)		 4y9a TRIOSEPHOSPHATE
ISOMERASE
(Streptomyces
coelicolor) 		4 / 5 PHE A 252
LEU A  10
GLY A 239
VAL A 223
 None
 1.01A 3wrkD-4y9aA:
undetectable		 3wrkD-4y9aA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4y9a TRIOSEPHOSPHATE
ISOMERASE
(Streptomyces
coelicolor) 		5 / 10 LEU A 247
VAL A  47
VAL A 242
GLY A  13
LEU A  19
 None
 1.29A 6bsgA-4y9aA:
undetectable		 6bsgA-4y9aA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4y9a TRIOSEPHOSPHATE
ISOMERASE
(Streptomyces
coelicolor) 		5 / 10 LEU A 247
VAL A  47
VAL A 242
GLY A  13
LEU A  19
 None
 1.17A 6bsiA-4y9aA:
undetectable		 6bsiA-4y9aA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4y9a TRIOSEPHOSPHATE
ISOMERASE
(Streptomyces
coelicolor) 		5 / 10 LEU A 247
VAL A  47
VAL A 242
GLY A  13
LEU A  19
 None
 1.29A 6bsjA-4y9aA:
1.5		 6bsjA-4y9aA:
14.62