SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y9d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 4y9d C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		4 / 4 ILE A  64
MET A 123
VAL A 184
GLY A 118
 NAI  A 401 (-3.9A)
None
None
None
 1.33A 1e06B-4y9dA:
undetectable		 1e06B-4y9dA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 4y9d C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		5 / 9 LEU A  62
ALA A  92
GLY A 118
LEU A  88
PHE A  10
 None
NAI  A 401 (-3.6A)
None
None
None
 1.12A 1nr6A-4y9dA:
undetectable		 1nr6A-4y9dA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_C_SAMC303_0
(HEMK PROTEIN)		 4y9d C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		5 / 12 ILE A  60
GLY A  14
ALA A  92
VAL A  47
ALA A  42
 None
None
NAI  A 401 (-3.6A)
None
None
 1.01A 1sg9C-4y9dA:
7.3		 1sg9C-4y9dA:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_C_SAMC303_0
(HEMK PROTEIN)		 4y9d C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		5 / 12 PHE A  20
ILE A  60
GLY A  14
SER A  89
ALA A  23
 None
 1.14A 1sg9C-4y9dA:
7.3		 1sg9C-4y9dA:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 4y9d C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		8 / 11 GLY A  13
ALA A  15
SER A  16
ASP A  37
ASP A  63
ALA A  92
VAL A  94
VAL A 114
 NAI  A 401 (-2.9A)
NAI  A 401 ( 4.3A)
NAI  A 401 (-2.9A)
NAI  A 401 (-2.6A)
NAI  A 401 (-2.6A)
NAI  A 401 (-3.6A)
NAI  A 401 (-4.5A)
NAI  A 401 ( 4.5A)
 0.55A 1uayA-4y9dA:
25.5		 1uayA-4y9dA:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 4y9d C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		8 / 10 GLY A  13
ALA A  15
SER A  16
ASP A  37
ASP A  63
ALA A  92
VAL A  94
VAL A 114
 NAI  A 401 (-2.9A)
NAI  A 401 ( 4.3A)
NAI  A 401 (-2.9A)
NAI  A 401 (-2.6A)
NAI  A 401 (-2.6A)
NAI  A 401 (-3.6A)
NAI  A 401 (-4.5A)
NAI  A 401 ( 4.5A)
 0.53A 1uayB-4y9dA:
25.7		 1uayB-4y9dA:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 4y9d C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		5 / 12 GLY A  13
GLY A  21
VAL A  38
ASP A  63
ILE A  64
 NAI  A 401 (-2.9A)
None
NAI  A 401 ( 4.3A)
NAI  A 401 (-2.6A)
NAI  A 401 (-3.9A)
 0.78A 2b25A-4y9dA:
7.1		 2b25A-4y9dA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA2_0
(FERROCHELATASE)		 4y9d C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		4 / 6 MET A 123
ARG A 172
PRO A  85
GLY A 137
 None
 1.09A 3aqiA-4y9dA:
2.4		 3aqiA-4y9dA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4y9d C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		4 / 8 PRO A 156
ALA A 160
ALA A 163
ILE A 112
 None
 0.80A 3dtuC-4y9dA:
undetectable
3dtuD-4y9dA:
undetectable		 3dtuC-4y9dA:
19.96
3dtuD-4y9dA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4y9d C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		4 / 5 ILE A 120
THR A  12
PHE A  10
PHE A 126
 None
 1.31A 3em0A-4y9dA:
undetectable		 3em0A-4y9dA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4y9d C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		5 / 12 GLY A  21
LEU A  87
VAL A 140
ILE A 237
LEU A  50
 None
 1.29A 3g9eA-4y9dA:
undetectable		 3g9eA-4y9dA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4y9d C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		5 / 12 GLY A  13
SER A  16
ASP A  37
ASP A  63
ILE A  64
 NAI  A 401 (-2.9A)
NAI  A 401 (-2.9A)
NAI  A 401 (-2.6A)
NAI  A 401 (-2.6A)
NAI  A 401 (-3.9A)
 0.82A 3iv6B-4y9dA:
7.7		 3iv6B-4y9dA:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4y9d C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		5 / 12 VAL A 142
SER A 158
GLY A  93
PHE A  97
GLY A 146
 None
None
NAI  A 401 ( 4.4A)
None
None
 1.43A 4pevB-4y9dA:
5.8		 4pevB-4y9dA:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4y9d C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		3 / 3 ALA A  71
TYR A  70
PRO A  85
 None
 0.72A 4zdyA-4y9dA:
undetectable		 4zdyA-4y9dA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_2
(PROTEASE E35D-DRV)		 4y9d C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		4 / 7 GLY A  14
ALA A  15
GLY A  59
ILE A  60
 None
NAI  A 401 ( 4.3A)
None
None
 0.65A 5kqyB-4y9dA:
undetectable		 5kqyB-4y9dA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 4y9d C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		5 / 10 GLY A  13
GLY A  19
THR A  12
ASN A  90
ILE A  64
 NAI  A 401 (-2.9A)
None
None
None
NAI  A 401 (-3.9A)
 1.21A 6exiA-4y9dA:
6.7		 6exiA-4y9dA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 4y9d C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		5 / 10 GLY A  13
GLY A  19
THR A  12
ASN A  90
ILE A  64
 NAI  A 401 (-2.9A)
None
None
None
NAI  A 401 (-3.9A)
 1.20A 6exiB-4y9dA:
7.8		 6exiB-4y9dA:
14.40