SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y9i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])		 4y9i MYCOBACTERIUM
TUBERCULOSIS
PARALOGOUS FAMILY 11
(Mycolicibacteriu
m
smegmatis) 		5 / 12 THR A  86
ASN A  84
GLY A  42
THR A  39
TYR A  50
 None
None
PO4  A 201 (-3.1A)
None
None
 1.49A 2axnA-4y9iA:
undetectable		 2axnA-4y9iA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 4y9i MYCOBACTERIUM
TUBERCULOSIS
PARALOGOUS FAMILY 11
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ARG A 102
LEU A 104
GLU A 105
 None
 0.54A 4l3gF-4y9iA:
undetectable		 4l3gF-4y9iA:
15.81