SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y9l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZ4_A_BEZA784_0
(MALT REGULATORY
PROTEIN)		 4y9l PROTEIN ACDH-11,
ISOFORM B
(Caenorhabditis
elegans) 		4 / 6 HIS A 145
LEU A  56
LEU A  60
PRO A  61
 None
 1.27A 1hz4A-4y9lA:
1.3		 1hz4A-4y9lA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4y9l PROTEIN ACDH-11,
ISOFORM B
(Caenorhabditis
elegans) 		4 / 6 GLU A 392
LEU A 557
LEU A 496
GLY A 497
 None
 0.92A 1n13H-4y9lA:
undetectable
1n13K-4y9lA:
undetectable		 1n13H-4y9lA:
12.01
1n13K-4y9lA:
7.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4y9l PROTEIN ACDH-11,
ISOFORM B
(Caenorhabditis
elegans) 		4 / 7 LEU A 557
LEU A 496
GLY A 497
GLU A 392
 None
 0.91A 1n13G-4y9lA:
undetectable
1n13J-4y9lA:
undetectable		 1n13G-4y9lA:
7.96
1n13J-4y9lA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)		 4y9l PROTEIN ACDH-11,
ISOFORM B
(Caenorhabditis
elegans) 		3 / 3 GLN A 227
ILE A 228
TYR A 233
 None
 0.71A 1vifA-4y9lA:
undetectable		 1vifA-4y9lA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4y9l PROTEIN ACDH-11,
ISOFORM B
(Caenorhabditis
elegans) 		4 / 6 ARG A 143
ILE A 332
GLY A 169
ALA A 170
 None
 0.99A 1wmqA-4y9lA:
undetectable		 1wmqA-4y9lA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4y9l PROTEIN ACDH-11,
ISOFORM B
(Caenorhabditis
elegans) 		4 / 6 ARG A 143
ILE A 332
GLY A 169
ALA A 170
 None
 0.98A 1wmqB-4y9lA:
undetectable		 1wmqB-4y9lA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4y9l PROTEIN ACDH-11,
ISOFORM B
(Caenorhabditis
elegans) 		4 / 6 ARG A 143
ILE A 332
GLY A 169
ALA A 170
 None
 0.98A 1wpuA-4y9lA:
undetectable		 1wpuA-4y9lA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4y9l PROTEIN ACDH-11,
ISOFORM B
(Caenorhabditis
elegans) 		4 / 6 ARG A 143
ILE A 332
GLY A 169
ALA A 170
 None
 0.99A 1wpuB-4y9lA:
undetectable		 1wpuB-4y9lA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4y9l PROTEIN ACDH-11,
ISOFORM B
(Caenorhabditis
elegans) 		4 / 6 ARG A 143
ILE A 332
GLY A 169
ALA A 170
 None
 0.97A 1wrqA-4y9lA:
undetectable		 1wrqA-4y9lA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4y9l PROTEIN ACDH-11,
ISOFORM B
(Caenorhabditis
elegans) 		4 / 6 ARG A 143
ILE A 332
GLY A 169
ALA A 170
 None
 0.98A 1wrqB-4y9lA:
undetectable		 1wrqB-4y9lA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4y9l PROTEIN ACDH-11,
ISOFORM B
(Caenorhabditis
elegans) 		5 / 12 ALA A 324
VAL A 217
SER A 267
GLY A 325
ILE A 326
 None
 1.16A 2dcfA-4y9lA:
undetectable		 2dcfA-4y9lA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 4y9l PROTEIN ACDH-11,
ISOFORM B
(Caenorhabditis
elegans) 		4 / 5 LEU A 523
LEU A 520
ILE A 586
ARG A 551
 None
 0.77A 2qd4A-4y9lA:
undetectable		 2qd4A-4y9lA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4y9l PROTEIN ACDH-11,
ISOFORM B
(Caenorhabditis
elegans) 		4 / 7 ASP A 168
ILE A 335
GLN A 206
ARG A 143
 None
 1.07A 2qqcG-4y9lA:
undetectable
2qqcJ-4y9lA:
undetectable		 2qqcG-4y9lA:
6.64
2qqcJ-4y9lA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 4y9l PROTEIN ACDH-11,
ISOFORM B
(Caenorhabditis
elegans) 		4 / 6 VAL A 226
GLN A 319
GLY A 322
LEU A 177
 None
 1.07A 3bjwE-4y9lA:
undetectable		 3bjwE-4y9lA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4y9l PROTEIN ACDH-11,
ISOFORM B
(Caenorhabditis
elegans) 		3 / 3 ASN A 337
HIS A 336
VAL A 147
 None
 0.89A 3elzB-4y9lA:
undetectable		 3elzB-4y9lA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4y9l PROTEIN ACDH-11,
ISOFORM B
(Caenorhabditis
elegans) 		5 / 11 GLN A 583
PRO A 584
ASP A 587
LEU A 588
ALA A 542
 None
 1.43A 3n23C-4y9lA:
undetectable		 3n23C-4y9lA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_A_ACRA701_2
(ALPHA-GLUCOSIDASE)		 4y9l PROTEIN ACDH-11,
ISOFORM B
(Caenorhabditis
elegans) 		4 / 5 PRO A 461
ILE A 462
TYR A 423
MET A 345
 None
 1.08A 3phaA-4y9lA:
0.0		 3phaA-4y9lA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 4y9l PROTEIN ACDH-11,
ISOFORM B
(Caenorhabditis
elegans) 		5 / 12 VAL A 249
ALA A 250
GLY A 205
ALA A 254
LEU A 185
 None
 1.16A 3qxyA-4y9lA:
undetectable		 3qxyA-4y9lA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 4y9l PROTEIN ACDH-11,
ISOFORM B
(Caenorhabditis
elegans) 		5 / 11 VAL A 249
ALA A 250
GLY A 205
ALA A 254
LEU A 185
 None
 1.18A 3rc0A-4y9lA:
0.2		 3rc0A-4y9lA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)		 4y9l PROTEIN ACDH-11,
ISOFORM B
(Caenorhabditis
elegans) 		4 / 6 SER A 176
LEU A 179
HIS A 183
THR A 173
 None
 1.29A 3thrB-4y9lA:
undetectable		 3thrB-4y9lA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4y9l PROTEIN ACDH-11,
ISOFORM B
(Caenorhabditis
elegans) 		4 / 5 ARG A 334
VAL A 469
LEU A 472
SER A 471
 None
FAD  A 701 (-4.9A)
None
None
 1.22A 4e1gA-4y9lA:
0.0		 4e1gA-4y9lA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 4y9l PROTEIN ACDH-11,
ISOFORM B
(Caenorhabditis
elegans) 		4 / 7 ILE A 545
LEU A 520
LYS A 490
GLY A 489
 None
 0.85A 4hbfA-4y9lA:
undetectable		 4hbfA-4y9lA:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 4y9l PROTEIN ACDH-11,
ISOFORM B
(Caenorhabditis
elegans) 		4 / 8 PRO A  50
PRO A 155
ILE A 349
MET A 387
 None
 0.98A 4iilA-4y9lA:
undetectable		 4iilA-4y9lA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_1
(BLUE-LIGHT
PHOTORECEPTOR)		 4y9l PROTEIN ACDH-11,
ISOFORM B
(Caenorhabditis
elegans) 		5 / 12 VAL A 575
SER A 571
ASN A 569
LEU A 388
ILE A  51
 None
 1.09A 4kukA-4y9lA:
undetectable		 4kukA-4y9lA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 4y9l PROTEIN ACDH-11,
ISOFORM B
(Caenorhabditis
elegans) 		5 / 9 LEU A  52
ALA A 148
LEU A 390
PHE A 391
THR A  55
 None
 1.27A 4ltwA-4y9lA:
2.6		 4ltwA-4y9lA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4y9l PROTEIN ACDH-11,
ISOFORM B
(Caenorhabditis
elegans) 		3 / 3 LEU A 520
ILE A 586
ARG A 551
 None
 0.64A 4mk4B-4y9lA:
undetectable		 4mk4B-4y9lA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4y9l PROTEIN ACDH-11,
ISOFORM B
(Caenorhabditis
elegans) 		5 / 12 GLY A 320
GLY A 269
ILE A 316
GLY A 325
LEU A 177
 None
 0.83A 4n48A-4y9lA:
undetectable		 4n48A-4y9lA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4y9l PROTEIN ACDH-11,
ISOFORM B
(Caenorhabditis
elegans) 		5 / 12 GLY A 320
GLY A 269
ILE A 316
GLY A 325
LEU A 177
 None
 0.81A 4n48B-4y9lA:
undetectable		 4n48B-4y9lA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA205_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4y9l PROTEIN ACDH-11,
ISOFORM B
(Caenorhabditis
elegans) 		5 / 12 PHE A 391
GLU A 392
ALA A 556
GLY A 555
TYR A 579
 None
 1.18A 4oadA-4y9lA:
undetectable		 4oadA-4y9lA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 4y9l PROTEIN ACDH-11,
ISOFORM B
(Caenorhabditis
elegans) 		4 / 6 LEU A 330
ASN A 331
LEU A 470
ILE A 416
 None
 1.05A 4okxA-4y9lA:
1.9		 4okxA-4y9lA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_ACTA202_0
(RETINOL-BINDING
PROTEIN 2)		 4y9l PROTEIN ACDH-11,
ISOFORM B
(Caenorhabditis
elegans) 		4 / 6 GLU A 464
THR A 333
LEU A 330
GLN A 206
 None
 1.23A 4qztA-4y9lA:
undetectable		 4qztA-4y9lA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 4y9l PROTEIN ACDH-11,
ISOFORM B
(Caenorhabditis
elegans) 		5 / 12 GLY A 205
ALA A 250
SER A 161
PRO A 302
GLN A 300
 None
 1.30A 4rtpA-4y9lA:
undetectable		 4rtpA-4y9lA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 4y9l PROTEIN ACDH-11,
ISOFORM B
(Caenorhabditis
elegans) 		4 / 6 GLY A 286
ASP A 108
ASP A 279
ASP A 309
 None
 0.88A 4uckB-4y9lA:
undetectable		 4uckB-4y9lA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4y9l PROTEIN ACDH-11,
ISOFORM B
(Caenorhabditis
elegans) 		4 / 7 ALA A 394
ASP A  49
ARG A 346
GLY A 343
 None
 0.85A 5bs8A-4y9lA:
undetectable
5bs8C-4y9lA:
undetectable
5bs8D-4y9lA:
undetectable		 5bs8A-4y9lA:
25.00
5bs8C-4y9lA:
25.00
5bs8D-4y9lA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4y9l PROTEIN ACDH-11,
ISOFORM B
(Caenorhabditis
elegans) 		4 / 7 ALA A 394
ASP A  49
ARG A 346
GLY A 343
 None
 0.86A 5bs8A-4y9lA:
undetectable
5bs8B-4y9lA:
undetectable
5bs8C-4y9lA:
undetectable		 5bs8A-4y9lA:
25.00
5bs8B-4y9lA:
19.48
5bs8C-4y9lA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4y9l PROTEIN ACDH-11,
ISOFORM B
(Caenorhabditis
elegans) 		4 / 6 ALA A 186
THR A 187
VAL A 190
HIS A 183
 None
 1.00A 5eckA-4y9lA:
undetectable		 5eckA-4y9lA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4y9l PROTEIN ACDH-11,
ISOFORM B
(Caenorhabditis
elegans) 		4 / 6 ALA A 186
THR A 187
VAL A 190
HIS A 183
 None
 0.83A 5eclA-4y9lA:
undetectable		 5eclA-4y9lA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4y9l PROTEIN ACDH-11,
ISOFORM B
(Caenorhabditis
elegans) 		4 / 6 ALA A 186
THR A 187
VAL A 190
HIS A 183
 None
 0.71A 5eclD-4y9lA:
undetectable		 5eclD-4y9lA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4y9l PROTEIN ACDH-11,
ISOFORM B
(Caenorhabditis
elegans) 		5 / 7 ALA A 186
THR A 187
VAL A 190
TYR A 180
HIS A 183
 None
 1.43A 5ecoD-4y9lA:
undetectable		 5ecoD-4y9lA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 4y9l PROTEIN ACDH-11,
ISOFORM B
(Caenorhabditis
elegans) 		3 / 3 VAL A 160
GLN A 121
CYH A 123
 None
 0.83A 5icxA-4y9lA:
undetectable
5icxE-4y9lA:
undetectable		 5icxA-4y9lA:
15.97
5icxE-4y9lA:
3.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_1
(TETRACYCLINE
DESTRUCTASE TET(50))		 4y9l PROTEIN ACDH-11,
ISOFORM B
(Caenorhabditis
elegans) 		4 / 5 ASP A 473
ARG A 476
LEU A 253
MET A 208
 None
 1.37A 5tuiB-4y9lA:
1.4		 5tuiB-4y9lA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 4y9l PROTEIN ACDH-11,
ISOFORM B
(Caenorhabditis
elegans) 		4 / 5 ARG A 346
PHE A 151
LEU A 152
LEU A 453
 None
 1.05A 5veuH-4y9lA:
undetectable		 5veuH-4y9lA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 4y9l PROTEIN ACDH-11,
ISOFORM B
(Caenorhabditis
elegans) 		3 / 3 LEU A 558
VAL A 381
ASP A 382
 None
 0.63A 5x23A-4y9lA:
undetectable		 5x23A-4y9lA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 4y9l PROTEIN ACDH-11,
ISOFORM B
(Caenorhabditis
elegans) 		3 / 3 TYR A 233
ASP A 229
ASP A 231
 None
 0.64A 5x6yA-4y9lA:
undetectable		 5x6yA-4y9lA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_0
(SERUM ALBUMIN)		 4y9l PROTEIN ACDH-11,
ISOFORM B
(Caenorhabditis
elegans) 		5 / 12 ILE A 129
LEU A 388
LEU A  59
ARG A 143
LEU A 396
 None
 1.47A 6a7pB-4y9lA:
undetectable		 6a7pB-4y9lA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 4y9l PROTEIN ACDH-11,
ISOFORM B
(Caenorhabditis
elegans) 		6 / 12 LEU A  56
LEU A  72
SER A 154
LEU A  52
THR A  55
LEU A 390
 None
 1.40A 6b0cD-4y9lA:
undetectable		 6b0cD-4y9lA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_B_DZPB502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		 4y9l PROTEIN ACDH-11,
ISOFORM B
(Caenorhabditis
elegans) 		5 / 11 ILE A 348
LEU A 453
THR A 298
THR A 460
LEU A 342
 None
None
FAD  A 701 ( 4.2A)
None
None
 1.50A 6hupA-4y9lA:
2.6
6hupB-4y9lA:
3.6		 6hupA-4y9lA:
10.45
6hupB-4y9lA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4y9l PROTEIN ACDH-11,
ISOFORM B
(Caenorhabditis
elegans) 		4 / 7 ASP A 191
TYR A 180
ASP A 135
GLU A 134
 None
 1.06A 6mn5E-4y9lA:
undetectable		 6mn5E-4y9lA:
10.67