SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y9s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)		 4y9s EPOXIDE HYDROLASE
(Solanum
tuberosum) 		3 / 3 ALA A 111
VAL A 102
TRP A  40
 None
 0.89A 1av2C-4y9sA:
undetectable
1av2D-4y9sA:
undetectable		 1av2C-4y9sA:
5.11
1av2D-4y9sA:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_A_DVAA6_0
(GRAMICIDIN A)		 4y9s EPOXIDE HYDROLASE
(Solanum
tuberosum) 		3 / 3 ALA A 108
VAL A 102
TRP A  40
 None
 0.90A 1nrmA-4y9sA:
undetectable		 1nrmA-4y9sA:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_B_DVAB6_0
(GRAMICIDIN A)		 4y9s EPOXIDE HYDROLASE
(Solanum
tuberosum) 		3 / 3 ALA A 108
VAL A 102
TRP A  40
 None
 0.90A 1nrmB-4y9sA:
undetectable		 1nrmB-4y9sA:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_A_DVAA6_0
(GRAMICIDIN A)		 4y9s EPOXIDE HYDROLASE
(Solanum
tuberosum) 		3 / 3 ALA A 108
VAL A 102
TRP A  40
 None
 0.94A 1nruA-4y9sA:
undetectable		 1nruA-4y9sA:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_B_DVAB6_0
(GRAMICIDIN A)		 4y9s EPOXIDE HYDROLASE
(Solanum
tuberosum) 		3 / 3 ALA A 108
VAL A 102
TRP A  40
 None
 0.94A 1nruB-4y9sA:
undetectable		 1nruB-4y9sA:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_A_DVAA6_0
(GRAMICIDIN A)		 4y9s EPOXIDE HYDROLASE
(Solanum
tuberosum) 		3 / 3 ALA A 108
VAL A 102
TRP A  40
 None
 0.86A 1nt5A-4y9sA:
undetectable		 1nt5A-4y9sA:
5.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_B_DVAB6_0
(GRAMICIDIN A)		 4y9s EPOXIDE HYDROLASE
(Solanum
tuberosum) 		3 / 3 ALA A 108
VAL A 102
TRP A  40
 None
 0.86A 1nt5B-4y9sA:
undetectable		 1nt5B-4y9sA:
5.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)		 4y9s EPOXIDE HYDROLASE
(Solanum
tuberosum) 		4 / 7 ASP A  64
TYR A  62
ASP A  58
HIS A   6
 None
 1.26A 1t03A-4y9sA:
undetectable		 1t03A-4y9sA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4y9s EPOXIDE HYDROLASE
(Solanum
tuberosum) 		5 / 12 HIS A 104
ASP A 265
LEU A 266
THR A 182
PHE A 189
 None
 1.43A 1xoqA-4y9sA:
undetectable		 1xoqA-4y9sA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4y9s EPOXIDE HYDROLASE
(Solanum
tuberosum) 		5 / 12 HIS A 104
ASP A 265
LEU A 266
THR A 182
PHE A 189
 None
 1.42A 1xoqB-4y9sA:
undetectable		 1xoqB-4y9sA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 4y9s EPOXIDE HYDROLASE
(Solanum
tuberosum) 		4 / 7 TYR A  46
TYR A 315
ASP A 316
HIS A 308
 None
 1.24A 2pncA-4y9sA:
undetectable		 2pncA-4y9sA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4y9s EPOXIDE HYDROLASE
(Solanum
tuberosum) 		5 / 12 HIS A 104
ASP A 265
LEU A 266
THR A 182
PHE A 189
 None
 1.41A 3g4lB-4y9sA:
undetectable		 3g4lB-4y9sA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 4y9s EPOXIDE HYDROLASE
(Solanum
tuberosum) 		3 / 3 PHE A  29
TYR A  46
LEU A  36
 None
 0.75A 3keeB-4y9sA:
undetectable		 3keeB-4y9sA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4y9s EPOXIDE HYDROLASE
(Solanum
tuberosum) 		5 / 12 VAL A 141
LEU A 145
TYR A 235
LEU A 238
SER A 133
 None
 1.17A 3kk6B-4y9sA:
undetectable		 3kk6B-4y9sA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4y9s EPOXIDE HYDROLASE
(Solanum
tuberosum) 		4 / 5 VAL A  82
LEU A  81
ILE A  30
ALA A 111
 None
 0.92A 3n8yB-4y9sA:
undetectable		 3n8yB-4y9sA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 4y9s EPOXIDE HYDROLASE
(Solanum
tuberosum) 		5 / 12 GLY A  61
THR A 226
VAL A  11
PRO A  57
LEU A  88
 None
 1.10A 3v8vA-4y9sA:
undetectable		 3v8vA-4y9sA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 4y9s EPOXIDE HYDROLASE
(Solanum
tuberosum) 		5 / 12 PHE A 158
PHE A 301
GLY A 172
LEU A 177
PHE A 223
 None
 1.05A 4kykA-4y9sA:
undetectable
4kykB-4y9sA:
undetectable		 4kykA-4y9sA:
20.38
4kykB-4y9sA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4B_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4y9s EPOXIDE HYDROLASE
(Solanum
tuberosum) 		4 / 8 LEU A 125
VAL A 101
VAL A  82
VAL A  85
 None
 1.05A 4l4bA-4y9sA:
undetectable		 4l4bA-4y9sA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_B_Y70B151_1
(CEREBLON ISOFORM 4)		 4y9s EPOXIDE HYDROLASE
(Solanum
tuberosum) 		4 / 8 ASN A 136
PRO A 137
MET A 139
TYR A 276
 None
 1.27A 4v2zB-4y9sA:
undetectable		 4v2zB-4y9sA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V30_B_LVYB151_1
(CEREBLON ISOFORM 4)		 4y9s EPOXIDE HYDROLASE
(Solanum
tuberosum) 		4 / 8 ASN A 136
PRO A 137
MET A 139
TYR A 276
 None
 1.31A 4v30B-4y9sA:
undetectable		 4v30B-4y9sA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4y9s EPOXIDE HYDROLASE
(Solanum
tuberosum) 		4 / 4 LEU A  47
TYR A  38
PRO A 307
ILE A 310
 None
 1.28A 5esgA-4y9sA:
undetectable		 5esgA-4y9sA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4y9s EPOXIDE HYDROLASE
(Solanum
tuberosum) 		5 / 12 ALA A 298
TYR A 154
PHE A 168
ILE A 164
HIS A 104
 None
 1.30A 5jlcA-4y9sA:
undetectable		 5jlcA-4y9sA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4y9s EPOXIDE HYDROLASE
(Solanum
tuberosum) 		4 / 4 GLU A  90
PRO A  94
ILE A  92
LEU A  89
 None
 1.10A 5m45A-4y9sA:
undetectable		 5m45A-4y9sA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4y9s EPOXIDE HYDROLASE
(Solanum
tuberosum) 		4 / 4 GLU A  90
PRO A  94
ILE A  92
LEU A  89
 None
 1.16A 5m45D-4y9sA:
undetectable		 5m45D-4y9sA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4y9s EPOXIDE HYDROLASE
(Solanum
tuberosum) 		4 / 4 GLU A  90
PRO A  94
ILE A  92
LEU A  89
 None
 1.11A 5m45G-4y9sA:
undetectable		 5m45G-4y9sA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4y9s EPOXIDE HYDROLASE
(Solanum
tuberosum) 		4 / 4 GLU A  90
PRO A  94
ILE A  92
LEU A  89
 None
 1.15A 5m45J-4y9sA:
undetectable		 5m45J-4y9sA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_C_PFLC409_1
(PROTON-GATED ION
CHANNEL)		 4y9s EPOXIDE HYDROLASE
(Solanum
tuberosum) 		5 / 10 TYR A 190
PRO A 188
ILE A 148
TYR A 154
ILE A 155
 None
 1.10A 5mzrC-4y9sA:
undetectable		 5mzrC-4y9sA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4y9s EPOXIDE HYDROLASE
(Solanum
tuberosum) 		5 / 11 LEU A  47
GLY A  51
GLU A  23
GLY A  24
VAL A  55
 None
 1.03A 5o96G-4y9sA:
undetectable		 5o96G-4y9sA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)		 4y9s EPOXIDE HYDROLASE
(Solanum
tuberosum) 		5 / 9 LEU A  89
VAL A  82
LEU A 114
MET A  16
LEU A  18
 None
 1.27A 5og9A-4y9sA:
undetectable		 5og9A-4y9sA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4y9s EPOXIDE HYDROLASE
(Solanum
tuberosum) 		5 / 12 VAL A 302
SER A 303
TRP A  40
LEU A 125
VAL A 102
 None
 1.34A 6a93B-4y9sA:
undetectable		 6a93B-4y9sA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 4y9s EPOXIDE HYDROLASE
(Solanum
tuberosum) 		4 / 8 LEU A 125
VAL A 101
VAL A  82
VAL A  85
 None
 1.06A 6cp4A-4y9sA:
undetectable		 6cp4A-4y9sA:
21.40