SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y9t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 4y9t ABC TRANSPORTER,
SOLUTE BINDING
PROTEIN
(Agrobacterium
vitis) 		4 / 7 PHE A 331
THR A 322
VAL A 267
ILE A 321
 None
 0.89A 1p7rA-4y9tA:
undetectable		 1p7rA-4y9tA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4y9t ABC TRANSPORTER,
SOLUTE BINDING
PROTEIN
(Agrobacterium
vitis) 		4 / 5 ALA A 211
ASN A 212
ILE A 215
ASP A 214
 None
 1.14A 1yc2D-4y9tA:
5.7		 1yc2D-4y9tA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6K_A_ADNA699_1
(CHLORINASE)		 4y9t ABC TRANSPORTER,
SOLUTE BINDING
PROTEIN
(Agrobacterium
vitis) 		4 / 7 PHE A  94
TYR A 168
PRO A 167
THR A 169
 None
PA1  A 401 (-3.1A)
None
None
 1.25A 2q6kA-4y9tA:
3.8		 2q6kA-4y9tA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 4y9t ABC TRANSPORTER,
SOLUTE BINDING
PROTEIN
(Agrobacterium
vitis) 		4 / 8 GLY A 175
GLN A 173
TYR A 168
SER A 248
 None
None
PA1  A 401 (-3.1A)
None
 0.94A 4wryA-4y9tA:
2.9		 4wryA-4y9tA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 4y9t ABC TRANSPORTER,
SOLUTE BINDING
PROTEIN
(Agrobacterium
vitis) 		4 / 8 GLY A 175
GLN A 173
TYR A 168
SER A 248
 None
None
PA1  A 401 (-3.1A)
None
 0.95A 4wrzA-4y9tA:
2.9		 4wrzA-4y9tA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1008_1
(SERUM ALBUMIN)		 4y9t ABC TRANSPORTER,
SOLUTE BINDING
PROTEIN
(Agrobacterium
vitis) 		5 / 9 PHE A 114
ALA A  90
SER A  45
LEU A  49
VAL A  46
 None
 1.23A 4z69A-4y9tA:
undetectable		 4z69A-4y9tA:
20.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BR1_A_X6XA401_1
(ABC TRANSPORTER,
BINDING PROTEIN)		 4y9t ABC TRANSPORTER,
SOLUTE BINDING
PROTEIN
(Agrobacterium
vitis) 		11 / 11 ASP A  39
PHE A  41
GLN A  42
ASP A 115
ARG A 116
ASP A 166
TYR A 168
TRP A 196
HIS A 224
ASN A 249
GLN A 269
 PA1  A 401 (-2.8A)
PA1  A 401 (-3.6A)
PA1  A 401 (-3.8A)
PA1  A 401 (-3.0A)
PA1  A 401 (-4.0A)
PA1  A 401 (-3.1A)
PA1  A 401 (-3.1A)
PA1  A 401 (-3.6A)
PA1  A 401 (-4.5A)
PA1  A 401 (-4.0A)
PA1  A 401 (-3.0A)
 0.15A 5br1A-4y9tA:
55.4		 5br1A-4y9tA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND4_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4y9t ABC TRANSPORTER,
SOLUTE BINDING
PROTEIN
(Agrobacterium
vitis) 		5 / 12 LEU A  49
ALA A  48
PHE A  52
PRO A 338
LEU A 299
 None
 1.26A 5nd4B-4y9tA:
4.1		 5nd4B-4y9tA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4y9t ABC TRANSPORTER,
SOLUTE BINDING
PROTEIN
(Agrobacterium
vitis) 		3 / 3 LYS A 289
PRO A 290
LYS A 292
 None
 1.09A 5y9yA-4y9tA:
undetectable		 5y9yA-4y9tA:
20.70