SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y9v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G60_A_SAMA500_0
(ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA)
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus
AP22)
5 / 12 CYH A 467
ASP A 437
GLY A 435
SER A 429
THR A 433
None
SO4  A 809 ( 4.7A)
None
None
None
1.28A 1g60A-4y9vA:
undetectable
1g60A-4y9vA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus
AP22)
5 / 9 PHE A 194
LEU A 179
ILE A 164
VAL A 188
ILE A 192
None
1.34A 1gebA-4y9vA:
undetectable
1gebA-4y9vA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus
AP22)
5 / 12 THR A 456
ARG A 268
ARG A 401
GLY A 435
ALA A 405
None
SO4  A 809 ( 3.1A)
SO4  A 809 (-2.9A)
None
None
1.04A 1httD-4y9vA:
undetectable
1httD-4y9vA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus
AP22)
4 / 6 ARG A 357
GLY A 410
ASP A 409
TYR A 257
None
49T  A 815 ( 4.5A)
None
None
1.45A 1kf6M-4y9vA:
undetectable
1kf6N-4y9vA:
undetectable
1kf6M-4y9vA:
21.58
1kf6N-4y9vA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus
AP22)
4 / 7 PHE A 198
PHE A 200
PHE A 208
VAL A 171
None
1.01A 1lh6A-4y9vA:
undetectable
1lh6A-4y9vA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus
AP22)
4 / 7 PHE A 200
PHE A 208
PHE A 216
VAL A 171
None
0.98A 1lh6A-4y9vA:
undetectable
1lh6A-4y9vA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus
AP22)
5 / 12 ASP A 568
PRO A 500
GLY A 537
VAL A 539
ALA A 569
None
1.31A 1nw5A-4y9vA:
undetectable
1nw5A-4y9vA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus
AP22)
4 / 5 LEU A 427
ASN A 397
VAL A 422
ALA A 425
None
1.19A 2cizA-4y9vA:
undetectable
2cizA-4y9vA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus
AP22)
5 / 12 ALA A 403
TYR A 392
VAL A 422
GLY A 381
ILE A 382
None
1.21A 2dcfA-4y9vA:
undetectable
2dcfA-4y9vA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus
AP22)
5 / 12 ASP A 461
PHE A 488
GLY A 460
MET A 438
VAL A 478
EDO  A 802 (-4.0A)
None
EDO  A 802 ( 3.8A)
None
None
1.39A 2fqyA-4y9vA:
undetectable
2fqyA-4y9vA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus
AP22)
3 / 3 GLN A 170
LYS A 172
VAL A 176
EDO  A 804 (-4.1A)
None
EDO  A 808 ( 3.6A)
0.75A 2jfaB-4y9vA:
undetectable
2jfaB-4y9vA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus
AP22)
4 / 5 PHE A 198
PHE A 200
PHE A 208
VAL A 171
None
1.02A 2lh6A-4y9vA:
undetectable
2lh6A-4y9vA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_A_BEZA1162_0
(PEROXIREDOXIN-5)
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus
AP22)
5 / 10 THR A 497
GLY A 476
LEU A 570
PHE A 567
GLY A 537
None
1.31A 2vl2A-4y9vA:
undetectable
2vl2C-4y9vA:
undetectable
2vl2A-4y9vA:
14.22
2vl2C-4y9vA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus
AP22)
4 / 5 LEU A 501
THR A 497
THR A 540
HIS A 572
None
1.32A 2zj0C-4y9vA:
undetectable
2zj0C-4y9vA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus
AP22)
5 / 12 ALA A 403
TYR A 392
VAL A 422
GLY A 381
ILE A 382
None
1.37A 3a65A-4y9vA:
undetectable
3a65A-4y9vA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus
AP22)
5 / 12 VAL A 176
PHE A 216
PHE A 208
LEU A 318
HIS A 180
EDO  A 808 ( 3.6A)
None
None
None
EDO  A 805 (-4.6A)
1.37A 3apvA-4y9vA:
undetectable
3apvA-4y9vA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus
AP22)
5 / 12 VAL A 176
PHE A 216
PHE A 208
LEU A 318
HIS A 180
EDO  A 808 ( 3.6A)
None
None
None
EDO  A 805 (-4.6A)
1.36A 3apvB-4y9vA:
undetectable
3apvB-4y9vA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_2
(PROTEASE)
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus
AP22)
5 / 10 LEU A 354
VAL A 404
GLY A 394
ALA A 369
ILE A 382
None
0.97A 3ekpB-4y9vA:
undetectable
3ekpB-4y9vA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus
AP22)
5 / 9 LEU A 354
VAL A 404
GLY A 394
ALA A 369
ILE A 382
None
1.02A 3el0B-4y9vA:
undetectable
3el0B-4y9vA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus
AP22)
5 / 10 ILE A 724
PRO A 656
SER A 722
GLY A 723
LYS A 654
None
1.31A 3ik6B-4y9vA:
undetectable
3ik6E-4y9vA:
undetectable
3ik6B-4y9vA:
16.01
3ik6E-4y9vA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus
AP22)
5 / 10 LYS A 654
ILE A 724
PRO A 656
SER A 722
GLY A 723
None
1.28A 3ik6B-4y9vA:
undetectable
3ik6E-4y9vA:
undetectable
3ik6B-4y9vA:
16.01
3ik6E-4y9vA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_2
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus
AP22)
4 / 5 VAL A 304
PHE A 240
ILE A 232
PHE A 289
None
1.13A 3owxB-4y9vA:
undetectable
3owxB-4y9vA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus
AP22)
4 / 5 SER A 385
PRO A 416
TYR A 271
VAL A 415
None
1.41A 3sufC-4y9vA:
undetectable
3sufC-4y9vA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus
AP22)
4 / 7 ASN A 598
ALA A 603
PRO A 605
ARG A 571
None
1.08A 3twpA-4y9vA:
undetectable
3twpA-4y9vA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus
AP22)
5 / 10 VAL A 404
ALA A 405
GLY A 420
SER A 385
GLY A 407
None
None
None
None
49S  A 814 (-3.5A)
1.22A 4mmdA-4y9vA:
undetectable
4mmdA-4y9vA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus
AP22)
5 / 12 VAL A 404
ALA A 405
GLY A 420
SER A 385
GLY A 407
None
None
None
None
49S  A 814 (-3.5A)
1.19A 4mmdB-4y9vA:
undetectable
4mmdB-4y9vA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus
AP22)
4 / 5 ASN A 441
GLY A 407
ASP A 448
ASP A 437
49S  A 814 (-3.6A)
49S  A 814 (-3.5A)
None
SO4  A 809 ( 4.7A)
1.15A 4n48B-4y9vA:
undetectable
4n48B-4y9vA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus
AP22)
4 / 4 ASN A 441
GLY A 407
ASP A 448
ASP A 437
49S  A 814 (-3.6A)
49S  A 814 (-3.5A)
None
SO4  A 809 ( 4.7A)
1.12A 4n49A-4y9vA:
undetectable
4n49A-4y9vA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus
AP22)
4 / 6 THR A 206
LEU A 149
ASP A 150
LEU A 179
None
None
EDO  A 807 ( 3.6A)
None
0.74A 4wozA-4y9vA:
undetectable
4wozB-4y9vA:
undetectable
4wozA-4y9vA:
18.28
4wozB-4y9vA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus
AP22)
4 / 5 LEU A 149
ASP A 150
LEU A 179
THR A 206
None
EDO  A 807 ( 3.6A)
None
None
0.75A 4wozF-4y9vA:
undetectable
4wozH-4y9vA:
undetectable
4wozF-4y9vA:
18.28
4wozH-4y9vA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus
AP22)
4 / 6 PRO A 483
ILE A 510
VAL A 576
ARG A 472
None
1.07A 4xe5A-4y9vA:
undetectable
4xe5A-4y9vA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus
AP22)
5 / 12 ILE A 311
PHE A 362
LEU A 356
LEU A 354
LEU A 331
EDO  A 803 (-4.6A)
None
None
None
None
1.32A 4xumA-4y9vA:
undetectable
4xumA-4y9vA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus
AP22)
5 / 12 SER A 505
TRP A 575
ILE A 591
ILE A 541
GLY A 509
None
0.93A 4y8wC-4y9vA:
undetectable
4y8wC-4y9vA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus
AP22)
5 / 9 LEU A 354
VAL A 404
GLY A 395
ILE A 366
ILE A 382
None
1.13A 5kqxB-4y9vA:
undetectable
5kqxB-4y9vA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus
AP22)
3 / 3 HIS A 439
ASP A 437
HIS A 402
49S  A 814 ( 3.4A)
SO4  A 809 ( 4.7A)
SO4  A 809 (-3.9A)
0.71A 5oexA-4y9vA:
undetectable
5oexA-4y9vA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus
AP22)
3 / 3 HIS A 439
ASP A 437
HIS A 402
49S  A 814 ( 3.4A)
SO4  A 809 ( 4.7A)
SO4  A 809 (-3.9A)
0.74A 5oexB-4y9vA:
undetectable
5oexB-4y9vA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD601_0
(THIOCYANATE
DEHYDROGENASE)
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus
AP22)
3 / 3 HIS A 439
ASP A 437
HIS A 402
49S  A 814 ( 3.4A)
SO4  A 809 ( 4.7A)
SO4  A 809 (-3.9A)
0.76A 5oexD-4y9vA:
undetectable
5oexD-4y9vA:
21.36