SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yac'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)		 4yac C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		5 / 11 THR A  91
VAL A  18
GLY A  21
ASP A  38
VAL A  11
 None
NAI  A 500 (-4.0A)
None
NAI  A 500 (-2.6A)
None
 1.27A 1akdA-4yacA:
undetectable		 1akdA-4yacA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQU_A_EQIA329_0
(PROTEIN (ESTRADIOL
17
BETA-DEHYDROGENASE
1))		 4yac C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		5 / 10 SER A 144
LEU A 151
TYR A 157
GLY A 188
GLU A 215
 None
 1.33A 1equA-4yacA:
28.0		 1equA-4yacA:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 4yac C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		5 / 12 SER A 144
LEU A 151
TYR A 157
GLY A 188
PHE A 255
 None
 1.03A 1fdsA-4yacA:
29.5		 1fdsA-4yacA:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1502_0
(FERROCHELATASE)		 4yac C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		4 / 8 LEU A  87
PRO A 187
VAL A 238
GLY A 235
 None
 0.98A 1hrkA-4yacA:
3.9		 1hrkA-4yacA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2502_0
(FERROCHELATASE)		 4yac C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		4 / 8 LEU A  87
PRO A 187
VAL A 238
GLY A 235
 None
 0.98A 1hrkB-4yacA:
3.9		 1hrkB-4yacA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 4yac C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		5 / 11 SER A 144
LEU A 151
GLY A 188
PHE A 255
GLU A 215
 None
 1.28A 1iolA-4yacA:
27.8		 1iolA-4yacA:
27.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 4yac C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		5 / 11 SER A 144
TYR A 157
GLY A 188
PHE A 255
GLU A 215
 None
 0.82A 1iolA-4yacA:
27.8		 1iolA-4yacA:
27.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 4yac C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		5 / 9 LEU A  63
ALA A  92
GLY A 118
LEU A  88
PHE A  10
 None
NAI  A 500 ( 4.1A)
None
None
None
 1.17A 1nr6A-4yacA:
undetectable		 1nr6A-4yacA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 4yac C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		5 / 12 GLY A  13
GLY A  15
ILE A  39
ASP A  64
GLN A  22
 NAI  A 500 (-3.4A)
NAI  A 500 ( 4.2A)
NAI  A 500 (-3.8A)
NAI  A 500 (-3.6A)
None
 0.91A 1ri4A-4yacA:
6.9		 1ri4A-4yacA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)		 4yac C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		4 / 5 VAL A 119
GLY A 118
VAL A 116
TRP A 110
 None
 1.06A 1tkqB-4yacA:
undetectable		 1tkqB-4yacA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 4yac C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		7 / 11 GLY A  13
SER A  16
ASP A  38
ASP A  64
ALA A  92
VAL A  94
VAL A 114
 NAI  A 500 (-3.4A)
NAI  A 500 (-3.0A)
NAI  A 500 (-2.6A)
NAI  A 500 (-3.6A)
NAI  A 500 ( 4.1A)
NAI  A 500 ( 4.7A)
NAI  A 500 (-3.7A)
 0.64A 1uayA-4yacA:
25.5		 1uayA-4yacA:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 4yac C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		7 / 10 GLY A  13
SER A  16
ASP A  38
ASP A  64
ALA A  92
VAL A  94
VAL A 114
 NAI  A 500 (-3.4A)
NAI  A 500 (-3.0A)
NAI  A 500 (-2.6A)
NAI  A 500 (-3.6A)
NAI  A 500 ( 4.1A)
NAI  A 500 ( 4.7A)
NAI  A 500 (-3.7A)
 0.66A 1uayB-4yacA:
25.7		 1uayB-4yacA:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 4yac C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		5 / 11 THR A  91
VAL A  18
GLY A  21
ASP A  38
VAL A  11
 None
NAI  A 500 (-4.0A)
None
NAI  A 500 (-2.6A)
None
 1.24A 2a1nA-4yacA:
undetectable		 2a1nA-4yacA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 4yac C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		6 / 12 GLY A  13
GLY A  15
GLY A  21
ARG A  40
HIS A  43
ASP A  64
 NAI  A 500 (-3.4A)
NAI  A 500 ( 4.2A)
None
None
NAI  A 500 (-3.5A)
NAI  A 500 (-3.6A)
 1.22A 2b25A-4yacA:
6.7		 2b25A-4yacA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 4yac C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		5 / 12 GLY A  15
GLY A  21
ARG A  40
HIS A  43
ASP A  64
 NAI  A 500 ( 4.2A)
None
None
NAI  A 500 (-3.5A)
NAI  A 500 (-3.6A)
 1.16A 2b25B-4yacA:
6.4		 2b25B-4yacA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 4yac C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		5 / 10 THR A  91
VAL A  18
GLY A  21
ASP A  38
VAL A  11
 None
NAI  A 500 (-4.0A)
None
NAI  A 500 (-2.6A)
None
 1.22A 2cp4A-4yacA:
undetectable		 2cp4A-4yacA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4yac C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		5 / 12 TYR A  71
GLN A  22
LEU A  63
VAL A  85
VAL A 126
 None
 1.30A 2g70A-4yacA:
undetectable		 2g70A-4yacA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4yac C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		5 / 12 TYR A  71
GLN A  22
LEU A  63
VAL A  85
VAL A 126
 None
 1.28A 2g70B-4yacA:
7.0		 2g70B-4yacA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4yac C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		5 / 12 TYR A  71
GLN A  22
LEU A  63
VAL A  85
VAL A 126
 None
 1.24A 2g72B-4yacA:
undetectable		 2g72B-4yacA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 4yac C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		5 / 9 ALA A  92
ALA A  23
GLY A  21
GLY A  15
ILE A  36
 NAI  A 500 ( 4.1A)
None
None
NAI  A 500 ( 4.2A)
None
 1.12A 2v7bB-4yacA:
3.8		 2v7bB-4yacA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4yac C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		5 / 12 LEU A 234
VAL A  18
ILE A 225
TYR A 157
THR A  91
 None
NAI  A 500 (-4.0A)
None
None
None
 1.00A 3fl9B-4yacA:
2.2		 3fl9B-4yacA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4yac C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		5 / 12 LEU A 234
VAL A  18
ILE A 225
TYR A 157
THR A  91
 None
NAI  A 500 (-4.0A)
None
None
None
 1.00A 3fl9G-4yacA:
2.5		 3fl9G-4yacA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4yac C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		6 / 12 GLY A  13
GLY A  15
ASP A  38
ILE A  39
ASP A  64
ALA A  92
 NAI  A 500 (-3.4A)
NAI  A 500 ( 4.2A)
NAI  A 500 (-2.6A)
NAI  A 500 (-3.8A)
NAI  A 500 (-3.6A)
NAI  A 500 ( 4.1A)
 0.80A 4iv8A-4yacA:
7.5		 4iv8A-4yacA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4yac C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		6 / 12 GLY A  13
GLY A  15
ASP A  38
ILE A  39
ASP A  64
ALA A  92
 NAI  A 500 (-3.4A)
NAI  A 500 ( 4.2A)
NAI  A 500 (-2.6A)
NAI  A 500 (-3.8A)
NAI  A 500 (-3.6A)
NAI  A 500 ( 4.1A)
 0.76A 4iv8B-4yacA:
7.6		 4iv8B-4yacA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4yac C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		4 / 8 LEU A  26
VAL A  34
LEU A 185
LEU A 140
 None
 0.99A 4l1xA-4yacA:
undetectable		 4l1xA-4yacA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 4yac C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		4 / 4 LEU A 185
SER A 144
LEU A 250
LEU A 234
 None
 0.84A 4n09A-4yacA:
7.7		 4n09A-4yacA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 4yac C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		4 / 5 LEU A 185
SER A 144
LEU A 250
LEU A 234
 None
 0.85A 4n09B-4yacA:
7.5		 4n09B-4yacA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 4yac C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		4 / 5 LEU A 185
SER A 144
LEU A 250
LEU A 234
 None
 0.85A 4n09D-4yacA:
7.8		 4n09D-4yacA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4yac C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		4 / 6 PRO A 187
GLU A  28
ALA A   9
LEU A  87
 None
 1.05A 5igiA-4yacA:
undetectable		 5igiA-4yacA:
20.91