SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yah'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_A_CAMA503_0
(CYTOCHROME P450-CAM)		 4yah D-METHIONINE-BINDING
LIPOPROTEIN METQ
(Escherichia
coli) 		4 / 8 PHE X 246
TYR X 250
THR X 109
VAL X  37
 None
 1.15A 1dz9A-4yahX:
undetectable		 1dz9A-4yahX:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_B_CAMB1420_0
(CYTOCHROME P450-CAM)		 4yah D-METHIONINE-BINDING
LIPOPROTEIN METQ
(Escherichia
coli) 		4 / 8 PHE X 246
TYR X 250
THR X 109
VAL X  37
 None
 1.15A 1o76B-4yahX:
undetectable		 1o76B-4yahX:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_I_URFI2041_1
(URIDINE
PHOSPHORYLASE)		 4yah D-METHIONINE-BINDING
LIPOPROTEIN METQ
(Escherichia
coli) 		4 / 8 THR X 204
GLY X  40
ILE X  38
VAL X  39
 MET  X 301 (-4.0A)
None
None
None
 0.98A 1rxcI-4yahX:
undetectable		 1rxcI-4yahX:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_A_CAMA1416_0
(CYTOCHROME P450-CAM)		 4yah D-METHIONINE-BINDING
LIPOPROTEIN METQ
(Escherichia
coli) 		4 / 8 PHE X 246
TYR X 250
THR X 109
VAL X  37
 None
 1.14A 1uyuA-4yahX:
undetectable		 1uyuA-4yahX:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_B_CAMB1416_0
(CYTOCHROME P450-CAM)		 4yah D-METHIONINE-BINDING
LIPOPROTEIN METQ
(Escherichia
coli) 		4 / 8 PHE X 246
TYR X 250
THR X 109
VAL X  37
 None
 1.16A 1uyuB-4yahX:
undetectable		 1uyuB-4yahX:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 4yah D-METHIONINE-BINDING
LIPOPROTEIN METQ
(Escherichia
coli) 		4 / 8 ASP X  68
TYR X 205
TYR X  91
HIS X  88
 None
None
MET  X 301 (-2.8A)
MET  X 301 (-3.4A)
 1.36A 2ha2A-4yahX:
undetectable		 2ha2A-4yahX:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 4yah D-METHIONINE-BINDING
LIPOPROTEIN METQ
(Escherichia
coli) 		4 / 8 ASP X  68
TYR X 205
TYR X  91
HIS X  88
 None
None
MET  X 301 (-2.8A)
MET  X 301 (-3.4A)
 1.32A 2ha2B-4yahX:
undetectable		 2ha2B-4yahX:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4yah D-METHIONINE-BINDING
LIPOPROTEIN METQ
(Escherichia
coli) 		5 / 12 PHE X 110
LEU X  63
VAL X  61
PHE X 246
VAL X  37
 None
 1.44A 3u9fB-4yahX:
undetectable
3u9fC-4yahX:
undetectable		 3u9fB-4yahX:
21.24
3u9fC-4yahX:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4yah D-METHIONINE-BINDING
LIPOPROTEIN METQ
(Escherichia
coli) 		4 / 8 GLY X  36
VAL X  64
PHE X 246
ILE X  33
 None
 0.96A 4fglD-4yahX:
undetectable		 4fglD-4yahX:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4D_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4yah D-METHIONINE-BINDING
LIPOPROTEIN METQ
(Escherichia
coli) 		4 / 8 PHE X 246
TYR X 250
THR X 109
VAL X  37
 None
 1.17A 4l4dA-4yahX:
undetectable		 4l4dA-4yahX:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4E_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4yah D-METHIONINE-BINDING
LIPOPROTEIN METQ
(Escherichia
coli) 		4 / 8 PHE X 246
TYR X 250
THR X 109
VAL X  37
 None
 1.16A 4l4eA-4yahX:
undetectable		 4l4eA-4yahX:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4F_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4yah D-METHIONINE-BINDING
LIPOPROTEIN METQ
(Escherichia
coli) 		4 / 8 PHE X 246
TYR X 250
THR X 109
VAL X  37
 None
 1.15A 4l4fA-4yahX:
undetectable		 4l4fA-4yahX:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 4yah D-METHIONINE-BINDING
LIPOPROTEIN METQ
(Escherichia
coli) 		5 / 12 ALA X 206
SER X 207
GLY X 210
GLY X 217
TYR X 117
 None
 1.29A 4r29A-4yahX:
1.6		 4r29A-4yahX:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 4yah D-METHIONINE-BINDING
LIPOPROTEIN METQ
(Escherichia
coli) 		5 / 12 ALA X 206
SER X 207
GLY X 210
GLY X 217
TYR X 117
 None
 1.30A 4r29B-4yahX:
1.7		 4r29B-4yahX:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 4yah D-METHIONINE-BINDING
LIPOPROTEIN METQ
(Escherichia
coli) 		5 / 12 ALA X 206
SER X 207
GLY X 210
GLY X 217
TYR X 117
 None
 1.24A 4r29C-4yahX:
1.7		 4r29C-4yahX:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4yah D-METHIONINE-BINDING
LIPOPROTEIN METQ
(Escherichia
coli) 		4 / 5 VAL X  70
TYR X 117
ILE X 218
PRO X 136
 None
 1.24A 4ze1A-4yahX:
undetectable		 4ze1A-4yahX:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_2
(PROTEASE E35D-DRV)		 4yah D-METHIONINE-BINDING
LIPOPROTEIN METQ
(Escherichia
coli) 		4 / 7 GLY X  40
ALA X  41
GLY X 210
ILE X 209
 None
 0.63A 5kqyB-4yahX:
undetectable		 5kqyB-4yahX:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_2
(PROTEASE PR5-DRV)		 4yah D-METHIONINE-BINDING
LIPOPROTEIN METQ
(Escherichia
coli) 		4 / 8 GLY X  40
ALA X  41
GLY X 210
ILE X 209
 None
 0.60A 5kr1B-4yahX:
undetectable		 5kr1B-4yahX:
17.81