SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yai'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 4yai C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		5 / 9 GLY A  12
ASP A  36
ILE A  37
ALA A  92
ILE A 114
 NAI  A 500 (-2.8A)
NAI  A 500 (-2.2A)
NAI  A 500 (-3.7A)
NAI  A 500 (-3.7A)
NAI  A 500 (-3.4A)
 0.88A 1cetA-4yaiA:
8.2		 1cetA-4yaiA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1869_0
(FPRA)		 4yai C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		4 / 4 ASP A  40
HIS A  41
ARG A  38
GLU A 197
 None
NAI  A 500 (-3.9A)
None
None
 1.45A 1lqtA-4yaiA:
5.8		 1lqtA-4yaiA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 4yai C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		7 / 11 GLY A  12
ALA A  14
SER A  15
ASP A  36
ASP A  64
VAL A  65
ALA A  92
 NAI  A 500 (-2.8A)
NAI  A 500 ( 4.2A)
NAI  A 500 (-2.6A)
NAI  A 500 (-2.2A)
NAI  A 500 (-3.0A)
NAI  A 500 (-3.7A)
NAI  A 500 (-3.7A)
 0.66A 1uayA-4yaiA:
25.7		 1uayA-4yaiA:
28.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 4yai C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		7 / 10 GLY A  12
ALA A  14
SER A  15
ASP A  36
ASP A  64
VAL A  65
ALA A  92
 NAI  A 500 (-2.8A)
NAI  A 500 ( 4.2A)
NAI  A 500 (-2.6A)
NAI  A 500 (-2.2A)
NAI  A 500 (-3.0A)
NAI  A 500 (-3.7A)
NAI  A 500 (-3.7A)
 0.62A 1uayB-4yaiA:
26.1		 1uayB-4yaiA:
28.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 4yai C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		5 / 12 PHE A 126
GLY A 122
GLY A 118
ILE A  61
ALA A  74
 None
 1.00A 1v2xA-4yaiA:
2.7		 1v2xA-4yaiA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 4yai C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		5 / 12 THR A 171
ILE A 166
VAL A 185
ILE A 172
LEU A 247
 None
 1.14A 1z9hD-4yaiA:
undetectable		 1z9hD-4yaiA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 4yai C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		5 / 12 GLY A  12
GLY A  20
ARG A  38
HIS A  41
ASP A  64
 NAI  A 500 (-2.8A)
None
None
NAI  A 500 (-3.9A)
NAI  A 500 (-3.0A)
 1.01A 2b25A-4yaiA:
7.0		 2b25A-4yaiA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4yai C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		5 / 12 GLY A  12
ASP A  36
ASP A  64
ASN A  91
ALA A  92
 NAI  A 500 (-2.8A)
NAI  A 500 (-2.2A)
NAI  A 500 (-3.0A)
NAI  A 500 (-2.9A)
NAI  A 500 (-3.7A)
 1.03A 2bm9E-4yaiA:
5.4		 2bm9E-4yaiA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4yai C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		4 / 5 ARG A  46
THR A  60
LEU A  32
ALA A  45
 None
 1.49A 2e1qD-4yaiA:
undetectable		 2e1qD-4yaiA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6001_0
(PANTOTHENATE KINASE)		 4yai C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		5 / 11 ASN A  91
GLY A 235
ILE A 191
THR A 142
THR A 251
 NAI  A 500 (-2.9A)
None
NAI  A 500 (-4.5A)
NAI  A 500 (-3.2A)
None
 1.24A 2f9wA-4yaiA:
2.3
2f9wB-4yaiA:
2.1		 2f9wA-4yaiA:
25.86
2f9wB-4yaiA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 4yai C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		5 / 12 ILE A 120
LEU A 116
ASN A 115
ASN A 121
ILE A 114
 None
None
NAI  A 500 ( 4.4A)
None
NAI  A 500 (-3.4A)
 1.03A 2nnhA-4yaiA:
undetectable		 2nnhA-4yaiA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 4yai C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		5 / 10 ILE A 120
LEU A 116
ASN A 115
ASN A 121
ILE A 114
 None
None
NAI  A 500 ( 4.4A)
None
NAI  A 500 (-3.4A)
 1.05A 2nnhB-4yaiA:
undetectable		 2nnhB-4yaiA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 4yai C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		4 / 7 PHE A 126
ILE A  37
ILE A  94
GLY A 122
 None
NAI  A 500 (-3.7A)
NAI  A 500 ( 4.7A)
None
 0.96A 2v0mB-4yaiA:
undetectable		 2v0mB-4yaiA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1467_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 4yai C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		4 / 5 ARG A 202
ASP A 107
ILE A 157
GLU A 216
 None
 1.28A 2xrzA-4yaiA:
3.2
2xrzB-4yaiA:
3.1		 2xrzA-4yaiA:
21.22
2xrzB-4yaiA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 4yai C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		5 / 10 ASP A  36
ILE A  37
ALA A  14
ASP A  64
VAL A  65
 NAI  A 500 (-2.2A)
NAI  A 500 (-3.7A)
NAI  A 500 ( 4.2A)
NAI  A 500 (-3.0A)
NAI  A 500 (-3.7A)
 1.15A 3ay0A-4yaiA:
7.4		 3ay0A-4yaiA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 4yai C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		5 / 10 GLY A  13
ASP A  36
ILE A  37
ASP A  64
VAL A  65
 None
NAI  A 500 (-2.2A)
NAI  A 500 (-3.7A)
NAI  A 500 (-3.0A)
NAI  A 500 (-3.7A)
 1.05A 3ay0B-4yaiA:
7.5		 3ay0B-4yaiA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 4yai C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		5 / 10 SER A 193
LEU A 186
ILE A  21
SER A  15
GLY A  18
 NAI  A 500 (-2.7A)
None
None
NAI  A 500 (-2.6A)
None
 1.32A 3ik6B-4yaiA:
undetectable
3ik6E-4yaiA:
undetectable		 3ik6B-4yaiA:
21.50
3ik6E-4yaiA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 4yai C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		3 / 3 ARG A 135
ASP A   2
ASP A  86
 None
 0.87A 3jayA-4yaiA:
undetectable		 3jayA-4yaiA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4yai C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		5 / 12 GLY A 118
ASN A 141
ASP A  67
GLY A 122
MET A  71
 None
 1.15A 3ps9A-4yaiA:
2.6		 3ps9A-4yaiA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		 4yai C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		4 / 8 SER A 144
LEU A 145
TYR A 158
PRO A 190
 NAI  A 500 (-2.6A)
None
NAI  A 500 (-4.4A)
NAI  A 500 (-4.0A)
 0.89A 4j7uD-4yaiA:
22.8		 4j7uD-4yaiA:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_F_CAMF502_0
(CAMPHOR
5-MONOOXYGENASE)		 4yai C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		4 / 4 TYR A 248
THR A 171
VAL A 183
ILE A 166
 None
 1.23A 4jx1F-4yaiA:
undetectable		 4jx1F-4yaiA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_2
(SERUM ALBUMIN)		 4yai C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		4 / 4 ARG A  38
GLU A 204
ASP A  36
ARG A  62
 None
None
NAI  A 500 (-2.2A)
None
 1.20A 4l9qB-4yaiA:
0.0		 4l9qB-4yaiA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4yai C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		3 / 3 SER A 193
ASP A  36
ASP A  64
 NAI  A 500 (-2.7A)
NAI  A 500 (-2.2A)
NAI  A 500 (-3.0A)
 0.91A 4mwzA-4yaiA:
6.9		 4mwzA-4yaiA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 4yai C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		5 / 12 THR A  11
GLY A  13
ASP A  36
ILE A  37
SER A  66
 None
None
NAI  A 500 (-2.2A)
NAI  A 500 (-3.7A)
NAI  A 500 ( 4.1A)
 1.09A 4pooB-4yaiA:
8.7		 4pooB-4yaiA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_1
(PROTEASE)		 4yai C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		5 / 11 GLY A  20
ALA A  22
THR A  11
GLY A  12
THR A  60
 None
None
None
NAI  A 500 (-2.8A)
None
 0.97A 4qgiA-4yaiA:
undetectable		 4qgiA-4yaiA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 4yai C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		5 / 12 ASP A  36
GLY A  12
ALA A  92
ILE A  94
PRO A 203
 NAI  A 500 (-2.2A)
NAI  A 500 (-2.8A)
NAI  A 500 (-3.7A)
NAI  A 500 ( 4.7A)
NAI  A 500 ( 4.7A)
 0.78A 4xdrA-4yaiA:
undetectable		 4xdrA-4yaiA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 4yai C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		5 / 9 LEU A 168
THR A 169
PRO A 119
PRO A 188
LEU A 186
 None
None
None
NAI  A 500 (-3.7A)
None
 1.40A 5g48B-4yaiA:
undetectable		 5g48B-4yaiA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4yai C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		4 / 7 ILE A  10
HIS A  41
LEU A  42
ALA A  45
 None
NAI  A 500 (-3.9A)
None
None
 0.81A 5hrqE-4yaiA:
undetectable
5hrqF-4yaiA:
undetectable
5hrqJ-4yaiA:
undetectable		 5hrqE-4yaiA:
5.86
5hrqF-4yaiA:
6.81
5hrqJ-4yaiA:
6.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4yai C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		6 / 12 ILE A  10
GLY A  13
PHE A  48
ALA A  22
PHE A  49
ALA A   8
 None
 1.44A 5n0oB-4yaiA:
2.7		 5n0oB-4yaiA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4yai C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		6 / 12 ILE A  10
GLY A  13
PHE A  48
ALA A  22
PHE A  49
ALA A   8
 None
 1.49A 5n0tB-4yaiA:
2.4		 5n0tB-4yaiA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 4yai C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		4 / 8 GLY A 182
ARG A 131
ASP A 179
ASP A 174
 None
 0.81A 5vlmB-4yaiA:
undetectable		 5vlmB-4yaiA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)		 4yai C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		4 / 8 GLY A  93
ILE A  94
ASP A  36
HIS A  41
 NAI  A 500 (-3.0A)
NAI  A 500 ( 4.7A)
NAI  A 500 (-2.2A)
NAI  A 500 (-3.9A)
 1.05A 6ag0C-4yaiA:
undetectable		 6ag0C-4yaiA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 4yai C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		5 / 12 ALA A  72
ALA A 125
THR A 127
LEU A  88
ILE A  87
 None
 1.24A 6aybA-4yaiA:
undetectable		 6aybA-4yaiA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA607_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 4yai C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		4 / 4 GLY A  29
ARG A  24
ASN A  28
LEU A  26
 None
 1.42A 6b58A-4yaiA:
3.0		 6b58A-4yaiA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 4yai C
ALPHA-DEHYDROGENASE
(Sphingobium
sp.
SYK-6) 		5 / 9 ALA A  22
ALA A  14
GLY A  18
ALA A  35
GLY A  12
 None
NAI  A 500 ( 4.2A)
None
None
NAI  A 500 (-2.8A)
 0.95A 6bklE-4yaiA:
undetectable
6bklF-4yaiA:
undetectable
6bklG-4yaiA:
undetectable
6bklH-4yaiA:
undetectable		 6bklE-4yaiA:
6.71
6bklF-4yaiA:
6.71
6bklG-4yaiA:
6.71
6bklH-4yaiA:
6.71