SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yam'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4yam BETA-ETHERASE
(Sphingobium
sp.
SYK-6) 		4 / 5 GLU A 209
ARG A 229
ASP A 218
LEU A 217
 None
 1.17A 1n13B-4yamA:
undetectable
1n13C-4yamA:
undetectable		 1n13B-4yamA:
15.87
1n13C-4yamA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4yam BETA-ETHERASE
(Sphingobium
sp.
SYK-6) 		3 / 3 ARG A  26
VAL A  74
TRP A  73
 None
 1.03A 1qw6A-4yamA:
undetectable		 1qw6A-4yamA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QWC_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4yam BETA-ETHERASE
(Sphingobium
sp.
SYK-6) 		3 / 3 ARG A  26
VAL A  74
TRP A  73
 None
 0.95A 1qwcA-4yamA:
undetectable		 1qwcA-4yamA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4yam BETA-ETHERASE
(Sphingobium
sp.
SYK-6) 		3 / 3 ARG A  26
VAL A  74
TRP A  73
 None
 0.96A 1zviA-4yamA:
undetectable		 1zviA-4yamA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4yam BETA-ETHERASE
(Sphingobium
sp.
SYK-6) 		5 / 12 LEU A 166
LEU A 106
SER A 190
LEU A 179
THR A 198
 None
 1.19A 2oipC-4yamA:
undetectable		 2oipC-4yamA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)		 4yam BETA-ETHERASE
(Sphingobium
sp.
SYK-6) 		5 / 10 THR A  27
VAL A  59
VAL A  61
ILE A  40
VAL A  41
 None
 1.46A 2qboA-4yamA:
undetectable		 2qboA-4yamA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 4yam BETA-ETHERASE
(Sphingobium
sp.
SYK-6) 		4 / 8 LEU A 143
ILE A 119
TYR A 122
PHE A 115
 None
 0.99A 2weyB-4yamA:
undetectable		 2weyB-4yamA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4yam BETA-ETHERASE
(Sphingobium
sp.
SYK-6) 		5 / 12 LEU A 166
LEU A 106
SER A 190
LEU A 179
THR A 198
 None
 1.21A 3hj3A-4yamA:
undetectable		 3hj3A-4yamA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4yam BETA-ETHERASE
(Sphingobium
sp.
SYK-6) 		5 / 12 LEU A 166
LEU A 106
SER A 190
LEU A 179
THR A 198
 None
 1.10A 3hj3C-4yamA:
undetectable		 3hj3C-4yamA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4yam BETA-ETHERASE
(Sphingobium
sp.
SYK-6) 		4 / 7 VAL A  41
VAL A  24
ILE A  38
ARG A  55
 None
 1.24A 3ms9B-4yamA:
undetectable		 3ms9B-4yamA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		 4yam BETA-ETHERASE
(Sphingobium
sp.
SYK-6) 		4 / 5 GLY A 180
PRO A 184
ASN A 185
TYR A 189
 None
 0.94A 3u8qA-4yamA:
undetectable		 3u8qA-4yamA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 4yam BETA-ETHERASE
(Sphingobium
sp.
SYK-6) 		5 / 6 GLY A 180
PRO A 184
ASN A 185
TYR A 189
GLY A 220
 None
 0.95A 4fjpA-4yamA:
undetectable		 4fjpA-4yamA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 4yam BETA-ETHERASE
(Sphingobium
sp.
SYK-6) 		5 / 7 GLY A 180
PRO A 184
ASN A 185
TYR A 189
GLY A 220
 None
 0.95A 4forA-4yamA:
undetectable		 4forA-4yamA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 4yam BETA-ETHERASE
(Sphingobium
sp.
SYK-6) 		5 / 10 LEU A 102
LEU A 106
ALA A 191
LEU A 213
LEU A 179
 None
 1.28A 4p65A-4yamA:
undetectable
4p65B-4yamA:
undetectable
4p65F-4yamA:
undetectable
4p65H-4yamA:
undetectable		 4p65A-4yamA:
6.42
4p65B-4yamA:
7.12
4p65F-4yamA:
7.12
4p65H-4yamA:
7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4yam BETA-ETHERASE
(Sphingobium
sp.
SYK-6) 		5 / 12 LEU A 102
ASP A 103
ASN A 185
GLY A 180
PHE A 169
 None
 1.16A 4pgfA-4yamA:
undetectable		 4pgfA-4yamA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4yam BETA-ETHERASE
(Sphingobium
sp.
SYK-6) 		5 / 12 LEU A 166
LEU A 106
SER A 190
LEU A 179
THR A 198
 None
 1.22A 4q0dC-4yamA:
undetectable		 4q0dC-4yamA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4yam BETA-ETHERASE
(Sphingobium
sp.
SYK-6) 		5 / 12 LEU A 166
LEU A 106
SER A 190
LEU A 179
THR A 198
 None
 1.22A 4q0dD-4yamA:
undetectable		 4q0dD-4yamA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4yam BETA-ETHERASE
(Sphingobium
sp.
SYK-6) 		5 / 12 LEU A 236
GLY A 228
GLY A 226
MET A 233
LEU A 196
 None
 1.27A 4x61A-4yamA:
undetectable		 4x61A-4yamA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 4yam BETA-ETHERASE
(Sphingobium
sp.
SYK-6) 		5 / 12 PHE A 237
GLU A 209
PRO A 205
PHE A 221
GLY A 232
 None
 1.32A 4ydqA-4yamA:
undetectable		 4ydqA-4yamA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4yam BETA-ETHERASE
(Sphingobium
sp.
SYK-6) 		5 / 11 VAL A  24
PHE A 186
PHE A  90
TRP A  73
ILE A   7
 None
 1.47A 4zvmA-4yamA:
undetectable
4zvmB-4yamA:
undetectable		 4zvmA-4yamA:
21.55
4zvmB-4yamA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 4yam BETA-ETHERASE
(Sphingobium
sp.
SYK-6) 		4 / 8 LEU A 192
LEU A 173
ARG A 219
LEU A 106
 None
 1.22A 5dxeA-4yamA:
undetectable		 5dxeA-4yamA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4yam BETA-ETHERASE
(Sphingobium
sp.
SYK-6) 		3 / 3 ARG A  26
VAL A  74
TRP A  73
 None
 0.98A 5fvoA-4yamA:
undetectable		 5fvoA-4yamA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 4yam BETA-ETHERASE
(Sphingobium
sp.
SYK-6) 		5 / 12 GLU A 167
LEU A 173
ASP A 211
LEU A 106
ALA A 191
 None
 1.29A 5kbwA-4yamA:
undetectable		 5kbwA-4yamA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)		 4yam BETA-ETHERASE
(Sphingobium
sp.
SYK-6) 		4 / 7 ILE A 172
PHE A 169
ASP A 188
SER A 190
 None
 1.40A 5nr3A-4yamA:
undetectable		 5nr3A-4yamA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4yam BETA-ETHERASE
(Sphingobium
sp.
SYK-6) 		3 / 3 CYH A  18
MET A 233
ASN A 234
 None
 1.28A 5qh8A-4yamA:
undetectable		 5qh8A-4yamA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 4yam BETA-ETHERASE
(Sphingobium
sp.
SYK-6) 		5 / 12 PHE A 237
GLU A 209
PRO A 205
PHE A 221
GLY A 232
 None
 1.42A 5xioA-4yamA:
undetectable		 5xioA-4yamA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4yam BETA-ETHERASE
(Sphingobium
sp.
SYK-6) 		5 / 12 VAL A 162
LEU A 106
ALA A 110
PRO A 206
LEU A 236
 None
 0.95A 6b0iB-4yamA:
undetectable		 6b0iB-4yamA:
13.86