SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yaq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA501_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 4yaq PG9_N100FY FAB HEAVY
CHAIN
(Homo
sapiens) 		4 / 5 TYR H  90
LEU H  80
LEU H  82
ARG H  66
 None
 1.21A 4em2A-4yaqH:
undetectable		 4em2A-4yaqH:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 4yaq PG9_N100FY FAB HEAVY
CHAIN
(Homo
sapiens) 		3 / 3 ARG H  94
GLU H  95
PHE H  50
 PCA  H   2 (-4.0A)
None
None
 1.02A 4kszA-4yaqH:
undetectable		 4kszA-4yaqH:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 4yaq PG9_N100FY FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 11 SER H 197
GLY H 136
THR H 137
ALA H 138
THR H 133
 None
 1.01A 4qvyH-4yaqH:
undetectable		 4qvyH-4yaqH:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4yaq PG9_N100FY FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 SER H 197
GLY H 136
THR H 137
ALA H 138
THR H 133
 None
 1.02A 4qvyV-4yaqH:
undetectable
4qvyW-4yaqH:
undetectable		 4qvyV-4yaqH:
20.60
4qvyW-4yaqH:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4yaq PG9_N100FY FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 11 SER H 197
GLY H 136
THR H 137
ALA H 138
THR H 133
 None
 1.01A 5bxnH-4yaqH:
undetectable
5bxnI-4yaqH:
undetectable		 5bxnH-4yaqH:
20.60
5bxnI-4yaqH:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 4yaq PG9_N100FY FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 11 SER H 197
GLY H 136
THR H 137
ALA H 138
THR H 133
 None
 0.99A 5d0xV-4yaqH:
undetectable		 5d0xV-4yaqH:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4yaq PG9_N100FY FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 SER H 197
GLY H 136
THR H 137
ALA H 138
THR H 133
 None
 0.97A 5l5fH-4yaqH:
undetectable
5l5fI-4yaqH:
undetectable		 5l5fH-4yaqH:
20.60
5l5fI-4yaqH:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4yaq PG9_N100FY FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 SER H 197
GLY H 136
THR H 137
ALA H 138
THR H 133
 None
 0.97A 5l5fV-4yaqH:
undetectable
5l5fW-4yaqH:
undetectable		 5l5fV-4yaqH:
20.60
5l5fW-4yaqH:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 4yaq PG9_N100FY FAB HEAVY
CHAIN
(Homo
sapiens) 		4 / 5 GLU H  95
HIS H  35
LEU H  45
VAL H  37
 None
 1.19A 6bc9A-4yaqH:
undetectable		 6bc9A-4yaqH:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7M_B_68HB405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 4yaq PG9_N100FY FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 VAL H 171
VAL H 191
SER H 189
ASN H 209
ASN H 162
 None
None
None
MES  H 301 (-3.2A)
None
 1.46A 6h7mB-4yaqH:
undetectable		 6h7mB-4yaqH:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_V_BO2V301_0
(PROTEASOME SUBUNIT
BETA TYPE-2)		 4yaq PG9_N100FY FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 11 SER H 197
GLY H 136
THR H 137
ALA H 138
THR H 133
 None
 1.09A 6hwdV-4yaqH:
undetectable		 6hwdV-4yaqH:
15.20