SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yb6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 4yb6 ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Campylobacter
jejuni) 		4 / 6 LEU A 151
SER A 130
ASP A 169
GLU A 156
 None
None
AMP  A 301 (-3.5A)
AMP  A 301 ( 4.6A)
 1.23A 2j2pE-4yb6A:
undetectable
2j2pF-4yb6A:
undetectable		 2j2pE-4yb6A:
19.39
2j2pF-4yb6A:
19.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4yb6 ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Campylobacter
jejuni) 		5 / 10 GLY A 247
VAL A 248
GLU A 249
THR A 252
VAL A 268
 HIS  A 302 (-3.2A)
HIS  A 302 (-4.0A)
None
HIS  A 302 (-4.0A)
HIS  A 302 (-3.8A)
 0.00A 4yb6A-4yb6A:
40.8
4yb6E-4yb6A:
39.1		 4yb6A-4yb6A:
100.00
4yb6E-4yb6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4yb6 ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Campylobacter
jejuni) 		5 / 10 MET A 230
HIS A 232
LEU A 256
SER A 288
LEU A 290
 None
 0.04A 4yb6A-4yb6A:
40.8
4yb6E-4yb6A:
39.1		 4yb6A-4yb6A:
100.00
4yb6E-4yb6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4yb6 ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Campylobacter
jejuni) 		5 / 10 GLY A 247
VAL A 248
GLU A 249
THR A 252
VAL A 268
 HIS  A 302 (-3.2A)
HIS  A 302 (-4.0A)
None
HIS  A 302 (-4.0A)
HIS  A 302 (-3.8A)
 0.03A 4yb6B-4yb6A:
38.7
4yb6C-4yb6A:
38.7		 4yb6B-4yb6A:
100.00
4yb6C-4yb6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4yb6 ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Campylobacter
jejuni) 		5 / 10 MET A 230
HIS A 232
LEU A 256
SER A 288
LEU A 290
 None
 0.04A 4yb6B-4yb6A:
38.7
4yb6C-4yb6A:
38.7		 4yb6B-4yb6A:
100.00
4yb6C-4yb6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4yb6 ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Campylobacter
jejuni) 		5 / 10 GLY A 247
VAL A 248
GLU A 249
THR A 252
VAL A 268
 HIS  A 302 (-3.2A)
HIS  A 302 (-4.0A)
None
HIS  A 302 (-4.0A)
HIS  A 302 (-3.8A)
 0.29A 4yb6C-4yb6A:
38.6
4yb6F-4yb6A:
38.4		 4yb6C-4yb6A:
100.00
4yb6F-4yb6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4yb6 ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Campylobacter
jejuni) 		5 / 10 MET A 230
HIS A 232
LEU A 256
SER A 288
LEU A 290
 None
 0.03A 4yb6C-4yb6A:
38.6
4yb6F-4yb6A:
38.4		 4yb6C-4yb6A:
100.00
4yb6F-4yb6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4yb6 ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Campylobacter
jejuni) 		5 / 10 GLY A 247
VAL A 248
GLU A 249
THR A 252
VAL A 268
 HIS  A 302 (-3.2A)
HIS  A 302 (-4.0A)
None
HIS  A 302 (-4.0A)
HIS  A 302 (-3.8A)
 0.29A 4yb6A-4yb6A:
40.8
4yb6D-4yb6A:
39.3		 4yb6A-4yb6A:
100.00
4yb6D-4yb6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4yb6 ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Campylobacter
jejuni) 		5 / 10 MET A 230
HIS A 232
LEU A 256
SER A 288
LEU A 290
 None
 0.00A 4yb6A-4yb6A:
40.8
4yb6D-4yb6A:
39.3		 4yb6A-4yb6A:
100.00
4yb6D-4yb6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4yb6 ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Campylobacter
jejuni) 		5 / 10 GLY A 247
VAL A 248
GLU A 249
THR A 252
VAL A 268
 HIS  A 302 (-3.2A)
HIS  A 302 (-4.0A)
None
HIS  A 302 (-4.0A)
HIS  A 302 (-3.8A)
 0.29A 4yb6D-4yb6A:
39.3
4yb6E-4yb6A:
39.1		 4yb6D-4yb6A:
100.00
4yb6E-4yb6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4yb6 ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Campylobacter
jejuni) 		5 / 10 MET A 230
HIS A 232
LEU A 256
SER A 288
LEU A 290
 None
 0.05A 4yb6D-4yb6A:
39.3
4yb6E-4yb6A:
39.1		 4yb6D-4yb6A:
100.00
4yb6E-4yb6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4yb6 ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Campylobacter
jejuni) 		5 / 10 GLY A 247
VAL A 248
GLU A 249
THR A 252
VAL A 268
 HIS  A 302 (-3.2A)
HIS  A 302 (-4.0A)
None
HIS  A 302 (-4.0A)
HIS  A 302 (-3.8A)
 0.08A 4yb6B-4yb6A:
38.7
4yb6F-4yb6A:
38.4		 4yb6B-4yb6A:
100.00
4yb6F-4yb6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4yb6 ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Campylobacter
jejuni) 		5 / 10 MET A 230
HIS A 232
LEU A 256
SER A 288
LEU A 290
 None
 0.03A 4yb6B-4yb6A:
38.7
4yb6F-4yb6A:
38.4		 4yb6B-4yb6A:
100.00
4yb6F-4yb6A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FEP_A_SAMA407_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 4yb6 ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Campylobacter
jejuni) 		5 / 12 GLN A  85
GLY A  88
LEU A  87
ILE A 196
TYR A  93
 None
 1.37A 5fepA-4yb6A:
undetectable		 5fepA-4yb6A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FES_A_SAMA408_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 4yb6 ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Campylobacter
jejuni) 		5 / 12 GLN A  85
GLY A  88
LEU A  87
ILE A 196
TYR A  93
 None
 1.38A 5fesA-4yb6A:
undetectable		 5fesA-4yb6A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 4yb6 ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Campylobacter
jejuni) 		4 / 6 LEU A 170
LEU A 134
SER A 191
ASN A  80
 AMP  A 301 (-4.3A)
None
None
MG  A 304 ( 4.2A)
 0.80A 6f88B-4yb6A:
undetectable		 6f88B-4yb6A:
12.92