SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ybq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 4ybq SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 5
(Rattus
norvegicus) 		5 / 10 LEU A 233
ALA A 232
LEU A 219
LEU A 220
LEU A 152
 None
 1.08A 1gwrA-4ybqA:
undetectable		 1gwrA-4ybqA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_B_ADNB2604_1
(5'-NUCLEOTIDASE)		 4ybq ANTIBODY FV FRAGMENT
HEAVY CHAIN
(Mus
musculus) 		5 / 10 GLY D  34
ARG D  73
PHE D  30
GLY D 100
PHE D  28
 None
 1.36A 1ho5B-4ybqD:
undetectable		 1ho5B-4ybqD:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUL_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4ybq SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 5
(Rattus
norvegicus) 		5 / 9 ALA A 395
TYR A 411
LEU A 396
GLY A 162
GLY A 150
 None
 1.37A 1rulH-4ybqA:
undetectable
1rulL-4ybqA:
undetectable		 1rulH-4ybqA:
17.25
1rulL-4ybqA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_3
(PHOSPHOLIPASE A2)		 4ybq SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 5
(Rattus
norvegicus) 		4 / 7 VAL A 144
ILE A 398
ARG A 340
LEU A 344
 None
 0.90A 3bjwF-4ybqA:
undetectable		 3bjwF-4ybqA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 4ybq SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 5
(Rattus
norvegicus) 		4 / 7 VAL A 144
ILE A 398
ARG A 340
LEU A 344
 None
 0.89A 3bjwH-4ybqA:
0.7		 3bjwH-4ybqA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4ybq SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 5
(Rattus
norvegicus) 		4 / 4 GLY A  84
GLY A  81
GLY A 135
GLY A 139
 None
 0.67A 3bogC-4ybqA:
undetectable		 3bogC-4ybqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4ybq SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 5
(Rattus
norvegicus) 		4 / 4 GLY A  84
GLY A  81
GLY A 135
GLY A 139
 None
 0.62A 3bogD-4ybqA:
undetectable		 3bogD-4ybqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 4ybq SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 5
(Rattus
norvegicus) 		5 / 11 ALA A 354
GLY A 291
ILE A 356
LEU A 352
ALA A 445
 None
 0.91A 3dcmX-4ybqA:
undetectable		 3dcmX-4ybqA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA309_1
(BETA-LACTAMASE)		 4ybq SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 5
(Rattus
norvegicus) 		4 / 5 ILE A 262
ARG A  97
GLU A 252
GLU A 151
 None
 1.27A 3ny4A-4ybqA:
undetectable		 3ny4A-4ybqA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 4ybq SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 5
(Rattus
norvegicus) 		5 / 12 LEU A 233
ALA A 232
LEU A 219
LEU A 220
LEU A 152
 None
 1.09A 3olsA-4ybqA:
undetectable		 3olsA-4ybqA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 4ybq SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 5
(Rattus
norvegicus) 		5 / 12 LEU A 233
ALA A 232
LEU A 219
LEU A 220
LEU A 152
 None
 1.09A 3olsB-4ybqA:
undetectable		 3olsB-4ybqA:
18.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4ybq ANTIBODY FV FRAGMENT
HEAVY CHAIN
(Mus
musculus) 		6 / 12 VAL D   3
ALA D  25
MET D  35
ARG D  73
ASN D  75
TYR D 109
 None
 1.02A 3qxvA-4ybqD:
20.9		 3qxvA-4ybqD:
58.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_C_MTXC2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4ybq ANTIBODY FV FRAGMENT
HEAVY CHAIN
(Mus
musculus) 		5 / 11 VAL D   3
ALA D  25
MET D  35
ARG D  73
ASN D  75
 None
 0.80A 3qxvC-4ybqD:
21.2		 3qxvC-4ybqD:
58.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4ybq SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 5
(Rattus
norvegicus) 		3 / 3 TYR A 218
LEU A 396
ARG A 217
 None
 0.79A 3sufB-4ybqA:
undetectable		 3sufB-4ybqA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 4ybq SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 5
(Rattus
norvegicus) 		5 / 7 TYR A  33
PHE A  29
VAL A 175
PHE A 179
ILE A 193
 None
 1.46A 3zjqA-4ybqA:
undetectable		 3zjqA-4ybqA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_A_HFGA1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 4ybq SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 5
(Rattus
norvegicus) 		5 / 12 VAL A 163
PRO A 392
THR A 451
SER A 290
GLY A 286
 None
 1.36A 4hvcA-4ybqA:
undetectable		 4hvcA-4ybqA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 4ybq SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 5
(Rattus
norvegicus) 		5 / 12 VAL A 163
PRO A 392
THR A 451
SER A 290
GLY A 286
 None
 1.31A 4hvcB-4ybqA:
undetectable		 4hvcB-4ybqA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 4ybq SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 5
(Rattus
norvegicus) 		5 / 12 VAL A 163
PRO A 392
THR A 451
SER A 290
GLY A 286
 None
 1.34A 4olfA-4ybqA:
undetectable		 4olfA-4ybqA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y28_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4ybq SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 5
(Rattus
norvegicus) 		5 / 9 PHE A 348
SER A 349
LEU A 344
GLY A 389
PHE A 268
 None
 1.47A 4y28A-4ybqA:
undetectable
4y28J-4ybqA:
undetectable		 4y28A-4ybqA:
21.71
4y28J-4ybqA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_2
(HIV-1 PROTEASE)		 4ybq SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 5
(Rattus
norvegicus) 		5 / 12 GLY A 203
ALA A 202
GLY A 196
ILE A 113
ILE A 109
 None
 0.84A 5e5kB-4ybqA:
undetectable		 5e5kB-4ybqA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4ybq SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 5
(Rattus
norvegicus) 		4 / 8 ASN A 342
LEU A 343
GLY A 347
SER A 349
 None
 0.93A 5m8rC-4ybqA:
undetectable		 5m8rC-4ybqA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_E_SAME501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4ybq SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 5
(Rattus
norvegicus) 		5 / 9 LEU A 161
PRO A 165
GLY A 159
LEU A 152
ARG A 217
 None
 1.31A 5o96E-4ybqA:
undetectable
5o96F-4ybqA:
undetectable		 5o96E-4ybqA:
19.11
5o96F-4ybqA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4ybq SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 5
(Rattus
norvegicus) 		5 / 10 LEU A 161
PRO A 165
GLY A 159
LEU A 152
ALA A 153
 None
 1.04A 5o96E-4ybqA:
undetectable
5o96F-4ybqA:
undetectable		 5o96E-4ybqA:
19.11
5o96F-4ybqA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 4ybq SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 5
(Rattus
norvegicus) 		5 / 12 VAL A 163
PRO A 392
THR A 451
SER A 290
GLY A 286
 None
 1.38A 5xioA-4ybqA:
undetectable		 5xioA-4ybqA:
19.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CJK_B_ACTB302_0
(IMMUNOGLOBULIN FAB
HEAVY CHAIN)		 4ybq ANTIBODY FV FRAGMENT
HEAVY CHAIN
(Mus
musculus) 		3 / 3 TYR D  61
GLY D  67
THR D  70
 None
 0.19A 6cjkB-4ybqD:
20.5		 6cjkB-4ybqD:
42.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_0
(PROTEASE)		 4ybq SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 5
(Rattus
norvegicus) 		5 / 12 GLY A 203
ALA A 202
GLY A 196
ILE A 113
ILE A 109
 None
 0.87A 6dh3A-4ybqA:
undetectable		 6dh3A-4ybqA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 4ybq SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 5
(Rattus
norvegicus) 		5 / 12 VAL A 163
PRO A 392
THR A 451
SER A 290
GLY A 286
 None
 1.22A 6mn8A-4ybqA:
undetectable		 6mn8A-4ybqA:
19.86