SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yc7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 4yc7 FORMIN-LIKE PROTEIN
2
(Homo
sapiens) 		5 / 11 LEU B 265
LEU B 269
VAL B 273
ILE B 225
LEU B 140
 None
 1.28A 2q6hA-4yc7B:
undetectable		 2q6hA-4yc7B:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 4yc7 FORMIN-LIKE PROTEIN
2
(Homo
sapiens) 		5 / 12 ILE B 283
MET B 232
ILE B 251
ALA B 252
LEU B 267
 None
 1.11A 3a50D-4yc7B:
undetectable		 3a50D-4yc7B:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 4yc7 FORMIN-LIKE PROTEIN
2
(Homo
sapiens) 		3 / 3 ARG B 115
MET B 226
ARG B 229
 None
 1.50A 3uvvA-4yc7B:
undetectable		 3uvvA-4yc7B:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 4yc7 FORMIN-LIKE PROTEIN
2
(Homo
sapiens) 		5 / 12 ILE B 283
ALA B 272
PHE B 323
PHE B 307
LEU B 303
 None
 1.23A 4cd2A-4yc7B:
undetectable		 4cd2A-4yc7B:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		 4yc7 FORMIN-LIKE PROTEIN
2
(Homo
sapiens) 		4 / 5 LEU B 284
ARG B 299
ILE B 324
ASN B 374
 None
 1.20A 4i00A-4yc7B:
undetectable		 4i00A-4yc7B:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 4yc7 FORMIN-LIKE PROTEIN
2
(Homo
sapiens) 		5 / 11 LEU B 140
VAL B 137
PHE B 125
LEU B 110
GLY B 132
 None
 1.36A 4zbqA-4yc7B:
undetectable		 4zbqA-4yc7B:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 4yc7 FORMIN-LIKE PROTEIN
2
(Homo
sapiens) 		5 / 12 ILE B 368
LEU B 267
LEU B 347
LEU B 353
PHE B 307
 None
 1.20A 5xxiA-4yc7B:
undetectable		 5xxiA-4yc7B:
21.97