SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yci'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4O8Z_A_BBIA402_1 (NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-3, MITOCHONDRIAL)	4yci	BONE MORPHOGENETIC PROTEIN 9 GROWTH FACTOR DOMAIN (Mus musculus)	4 / 5	PHE A 105 HIS A 108 LEU A 110 PRO A 229	None	1.46A	4o8zA-4yciA: undetectable	4o8zA-4yciA: 23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DNU_A_BEZA319_0 (SHKAI2IB)	4yci	BONE MORPHOGENETIC PROTEIN 9 GROWTH FACTOR DOMAIN (Mus musculus)	4 / 5	GLN A 121 HIS A 119 ILE A 122 ILE A 85	None ZN A 303 (-2.9A) None None	1.10A	5dnuA-4yciA: undetectable	5dnuA-4yciA: 22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DNV_A_BEZA304_0 (SHKAI2IB)	4yci	BONE MORPHOGENETIC PROTEIN 9 GROWTH FACTOR DOMAIN (Mus musculus)	4 / 5	GLN A 121 HIS A 119 ILE A 122 ILE A 85	None ZN A 303 (-2.9A) None None	1.14A	5dnvA-4yciA: undetectable	5dnvA-4yciA: 22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IQE_D_NMYD600_1 (BIFUNCTIONAL AAC/APH)	4yci	BONE MORPHOGENETIC PROTEIN 9 GROWTH FACTOR DOMAIN (Mus musculus)	5 / 12	SER A 115 GLU A 120 SER A 235 GLU A 244 GLU A 251	NAG A 301 ( 3.8A) ZN A 303 (-2.7A) None ZN A 303 (-1.6A) None	1.50A	5iqeD-4yciA: undetectable	5iqeD-4yciA: 21.87

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4O8Z_A_BBIA402_1","NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-3, MITOCHONDRIAL","4yci","BONE MORPHOGENETIC PROTEIN 9 GROWTH FACTOR DOMAIN","Mus musculus",4,"PHE A 105;HIS A 108;LEU A 110;PRO A 229","None","1.46A","4o8zA-4yciA:undetectable","4o8zA-4yciA:23.24"],["5DNU_A_BEZA319_0","SHKAI2IB","4yci","BONE MORPHOGENETIC PROTEIN 9 GROWTH FACTOR DOMAIN","Mus musculus",4,"GLN A 121;HIS A 119;ILE A 122;ILE A  85","None; ZN A 303 (-2.9A);None;None","1.10A","5dnuA-4yciA:undetectable","5dnuA-4yciA:22.87"],["5DNV_A_BEZA304_0","SHKAI2IB","4yci","BONE MORPHOGENETIC PROTEIN 9 GROWTH FACTOR DOMAIN","Mus musculus",4,"GLN A 121;HIS A 119;ILE A 122;ILE A  85","None; ZN A 303 (-2.9A);None;None","1.14A","5dnvA-4yciA:undetectable","5dnvA-4yciA:22.87"],["5IQE_D_NMYD600_1","BIFUNCTIONAL AAC\/APH","4yci","BONE MORPHOGENETIC PROTEIN 9 GROWTH FACTOR DOMAIN","Mus musculus",5,"SER A 115;GLU A 120;SER A 235;GLU A 244;GLU A 251","NAG A 301 ( 3.8A); ZN A 303 (-2.7A);None; ZN A 303 (-1.6A);None","1.50A","5iqeD-4yciA:undetectable","5iqeD-4yciA:21.87"]]