SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yco'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 4yco TRNA-DIHYDROURIDINE
SYNTHASE C
(Escherichia
coli) 		5 / 11 LEU A  12
ALA A 227
VAL A  16
TYR A 279
GLN A 275
 None
None
None
C  D  17 ( 4.3A)
G  D  19 ( 3.6A)
 1.02A 1rlbF-4ycoA:
undetectable		 1rlbF-4ycoA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 4yco TRNA-DIHYDROURIDINE
SYNTHASE C
(Escherichia
coli) 		3 / 3 ARG A 272
TYR A 268
LYS A 261
 U  D  20 ( 4.0A)
None
None
 0.56A 1uujB-4ycoA:
undetectable		 1uujB-4ycoA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 4yco TRNA-DIHYDROURIDINE
SYNTHASE C
(Escherichia
coli) 		4 / 6 LEU A  20
ASN A  24
ILE A 223
ALA A 227
 None
 1.06A 2j5mA-4ycoA:
undetectable		 2j5mA-4ycoA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KI5_B_AC2B2_1
(PROTEIN (THYMIDINE
KINASE))		 4yco TRNA-DIHYDROURIDINE
SYNTHASE C
(Escherichia
coli) 		5 / 12 GLU A 164
ILE A  30
MET A 222
ARG A   2
ARG A  66
 None
None
FMN  A 401 ( 4.8A)
None
None
 1.22A 2ki5B-4ycoA:
undetectable		 2ki5B-4ycoA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 4yco TRNA-DIHYDROURIDINE
SYNTHASE C
(Escherichia
coli) 		3 / 3 GLU A   9
ASP A  13
TYR A 268
 U  D  16 (-4.6A)
None
None
 0.79A 2yvlB-4ycoA:
1.8		 2yvlB-4ycoA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4yco TRNA-DIHYDROURIDINE
SYNTHASE C
(Escherichia
coli) 		5 / 12 ILE A 119
ALA A 160
LYS A 139
ILE A 189
ILE A 153
 None
None
FMN  A 401 (-2.6A)
None
None
 1.07A 3ql3A-4ycoA:
undetectable		 3ql3A-4ycoA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4yco TRNA-DIHYDROURIDINE
SYNTHASE C
(Escherichia
coli) 		5 / 12 ILE A 119
ALA A 160
LYS A 139
ILE A 189
ILE A 153
 None
None
FMN  A 401 (-2.6A)
None
None
 1.01A 4p3qA-4ycoA:
undetectable		 4p3qA-4ycoA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4yco TRNA-DIHYDROURIDINE
SYNTHASE C
(Escherichia
coli) 		5 / 12 GLY A 109
GLY A  71
LEU A  69
SER A 106
ALA A  98
 None
None
None
A  D  14 ( 2.7A)
U  D  16 ( 3.3A)
 0.94A 4qtuB-4ycoA:
undetectable		 4qtuB-4ycoA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 4yco TRNA-DIHYDROURIDINE
SYNTHASE C
(Escherichia
coli) 		3 / 3 ARG A 177
GLN A 174
GLU A 173
 None
 0.85A 4tvtA-4ycoA:
undetectable		 4tvtA-4ycoA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4yco TRNA-DIHYDROURIDINE
SYNTHASE C
(Escherichia
coli) 		4 / 5 GLU A  18
THR A  21
THR A  31
LEU A  53
 None
 1.21A 5axaA-4ycoA:
undetectable		 5axaA-4ycoA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4yco TRNA-DIHYDROURIDINE
SYNTHASE C
(Escherichia
coli) 		4 / 5 GLU A  18
THR A  21
THR A  31
LEU A  53
 None
 1.21A 5axaC-4ycoA:
undetectable		 5axaC-4ycoA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 4yco TRNA-DIHYDROURIDINE
SYNTHASE C
(Escherichia
coli) 		3 / 3 VAL A 136
THR A 163
ARG A 127
 None
 0.76A 5b2sB-4ycoA:
3.4		 5b2sB-4ycoA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 4yco TRNA-DIHYDROURIDINE
SYNTHASE C
(Escherichia
coli) 		3 / 3 VAL A 136
THR A 163
ARG A 127
 None
 0.78A 5b2tB-4ycoA:
3.2		 5b2tB-4ycoA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 4yco TRNA-DIHYDROURIDINE
SYNTHASE C
(Escherichia
coli) 		4 / 8 ILE A 119
LEU A 193
ILE A 195
LEU A 113
 None
 0.96A 5ieoA-4ycoA:
undetectable		 5ieoA-4ycoA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		 4yco TRNA-DIHYDROURIDINE
SYNTHASE C
(Escherichia
coli) 		5 / 12 TRP A 204
GLY A 224
ILE A 223
TRP A 276
TYR A 279
 None
FMN  A 401 (-3.6A)
None
None
C  D  17 ( 4.3A)
 1.46A 5nz0A-4ycoA:
undetectable		 5nz0A-4ycoA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 4yco TRNA-DIHYDROURIDINE
SYNTHASE C
(Escherichia
coli) 		4 / 7 ARG A  58
THR A  59
PRO A  60
PRO A  51
 None
 1.39A 6a4iB-4ycoA:
undetectable		 6a4iB-4ycoA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4yco TRNA-DIHYDROURIDINE
SYNTHASE C
(Escherichia
coli) 		3 / 3 GLN A 207
TRP A 206
VAL A 237
 None
 1.10A 6auuA-4ycoA:
undetectable		 6auuA-4ycoA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_B_GM4B301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4yco TRNA-DIHYDROURIDINE
SYNTHASE C
(Escherichia
coli) 		5 / 11 VAL A 136
ALA A 162
TYR A 120
ALA A 123
LEU A  94
 None
 1.50A 6dk1B-4ycoA:
undetectable		 6dk1B-4ycoA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6I_A_8PRA509_1
(ENVELOPE
GLYCOPROTEIN,GP,GP1
ENVELOPE
GLYCOPROTEIN)		 4yco TRNA-DIHYDROURIDINE
SYNTHASE C
(Escherichia
coli) 		5 / 12 LEU A   5
GLY A 224
LEU A 280
LEU A  12
LEU A  20
 None
FMN  A 401 (-3.6A)
None
None
None
 1.08A 6f6iA-4ycoA:
undetectable
6f6iB-4ycoA:
undetectable		 6f6iA-4ycoA:
15.19
6f6iB-4ycoA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 4yco TRNA-DIHYDROURIDINE
SYNTHASE C
(Escherichia
coli) 		4 / 4 ASP A 155
ILE A 195
PRO A 196
LEU A 193
 None
 1.48A 6mkeB-4ycoA:
undetectable		 6mkeB-4ycoA:
13.19