SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ycr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_B_ANWB99_0
(PROTEIN S100-A13)		 4ycr TELLURITE RESISTANCE
PROTEIN TEHA HOMOLOG
(Haemophilus
influenzae) 		4 / 8 ALA A 206
VAL A 147
PHE A 151
THR A 152
 None
 0.69A 2kotB-4ycrA:
undetectable		 2kotB-4ycrA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 4ycr TELLURITE RESISTANCE
PROTEIN TEHA HOMOLOG
(Haemophilus
influenzae) 		4 / 7 SER A  24
THR A 302
ILE A  96
GLY A  15
 None
None
None
BOG  A 401 ( 4.2A)
 0.98A 2v0mB-4ycrA:
undetectable		 2v0mB-4ycrA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 4ycr TELLURITE RESISTANCE
PROTEIN TEHA HOMOLOG
(Haemophilus
influenzae) 		5 / 12 PHE A 260
GLY A 296
LEU A 297
LEU A 241
VAL A 293
 None
 1.09A 3av6A-4ycrA:
undetectable		 3av6A-4ycrA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 4ycr TELLURITE RESISTANCE
PROTEIN TEHA HOMOLOG
(Haemophilus
influenzae) 		5 / 10 GLY A 256
PHE A  80
PHE A 119
PHE A  82
GLY A  12
 BOG  A 401 ( 4.0A)
None
None
BOG  A 401 (-4.1A)
BOG  A 401 (-3.3A)
 1.48A 3ko0R-4ycrA:
undetectable
3ko0T-4ycrA:
0.9		 3ko0R-4ycrA:
15.38
3ko0T-4ycrA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 4ycr TELLURITE RESISTANCE
PROTEIN TEHA HOMOLOG
(Haemophilus
influenzae) 		5 / 11 ALA A  84
ILE A  88
SER A  81
LEU A 144
ALA A 148
 None
 1.04A 3kw2A-4ycrA:
undetectable		 3kw2A-4ycrA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 4ycr TELLURITE RESISTANCE
PROTEIN TEHA HOMOLOG
(Haemophilus
influenzae) 		5 / 11 ALA A  84
ILE A  88
SER A  81
LEU A 144
ALA A 148
 None
 1.05A 3kw2B-4ycrA:
undetectable		 3kw2B-4ycrA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 4ycr TELLURITE RESISTANCE
PROTEIN TEHA HOMOLOG
(Haemophilus
influenzae) 		4 / 5 LEU A 298
ALA A 259
PHE A 260
ASN A 254
 None
BOG  A 401 (-4.0A)
None
None
 1.22A 3uq6A-4ycrA:
undetectable		 3uq6A-4ycrA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 4ycr TELLURITE RESISTANCE
PROTEIN TEHA HOMOLOG
(Haemophilus
influenzae) 		4 / 4 LEU A 298
ALA A 259
PHE A 260
ASN A 254
 None
BOG  A 401 (-4.0A)
None
None
 1.28A 3vaqA-4ycrA:
undetectable		 3vaqA-4ycrA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 4ycr TELLURITE RESISTANCE
PROTEIN TEHA HOMOLOG
(Haemophilus
influenzae) 		4 / 4 LEU A 298
ALA A 259
PHE A 260
ASN A 254
 None
BOG  A 401 (-4.0A)
None
None
 1.28A 3vasA-4ycrA:
undetectable		 3vasA-4ycrA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ABZ_A_T1CA1209_1
(TETRACYCLINE
REPRESSOR CLASS D)		 4ycr TELLURITE RESISTANCE
PROTEIN TEHA HOMOLOG
(Haemophilus
influenzae) 		5 / 12 SER A 153
ASN A 150
THR A 113
GLN A 116
LEU A 122
 None
 1.36A 4abzA-4ycrA:
2.3		 4abzA-4ycrA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ycr TELLURITE RESISTANCE
PROTEIN TEHA HOMOLOG
(Haemophilus
influenzae) 		5 / 12 ILE A 295
ALA A 265
LEU A  18
ILE A  16
LEU A  23
 None
None
BOG  A 401 ( 4.9A)
None
None
 1.03A 4k6iA-4ycrA:
undetectable		 4k6iA-4ycrA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4ycr TELLURITE RESISTANCE
PROTEIN TEHA HOMOLOG
(Haemophilus
influenzae) 		4 / 7 PHE A 235
SER A 291
ALA A 271
SER A 270
 None
 1.27A 4lv9A-4ycrA:
undetectable
4lv9B-4ycrA:
undetectable		 4lv9A-4ycrA:
21.53
4lv9B-4ycrA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 4ycr TELLURITE RESISTANCE
PROTEIN TEHA HOMOLOG
(Haemophilus
influenzae) 		3 / 3 ARG A  99
TRP A 100
ILE A  96
 None
 1.08A 4mwxA-4ycrA:
undetectable		 4mwxA-4ycrA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_1
(ANDROGEN RECEPTOR)		 4ycr TELLURITE RESISTANCE
PROTEIN TEHA HOMOLOG
(Haemophilus
influenzae) 		5 / 12 LEU A 297
GLY A 296
LEU A  23
VAL A 289
VAL A  40
 None
 1.30A 4okxA-4ycrA:
undetectable		 4okxA-4ycrA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4ycr TELLURITE RESISTANCE
PROTEIN TEHA HOMOLOG
(Haemophilus
influenzae) 		5 / 12 SER A 156
LEU A  92
ALA A  21
LEU A  23
THR A 272
 None
 1.19A 4x1kA-4ycrA:
undetectable
4x1kB-4ycrA:
undetectable		 4x1kA-4ycrA:
20.09
4x1kB-4ycrA:
20.56