SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ycs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 4ycs UNCHARACTERIZED
PROTEIN
(Clostridioides
difficile) 		4 / 5 MET A  65
ALA A  69
ILE A 136
ASP A  56
 GOL  A 201 ( 4.3A)
None
None
None
 1.08A 1upfC-4ycsA:
2.4		 1upfC-4ycsA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 4ycs UNCHARACTERIZED
PROTEIN
(Clostridioides
difficile) 		5 / 11 ALA A 112
PRO A 120
ILE A 136
ASP A 137
ALA A 115
 None
None
None
GOL  A 201 (-3.0A)
None
 1.24A 2admA-4ycsA:
2.0		 2admA-4ycsA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 4ycs UNCHARACTERIZED
PROTEIN
(Clostridioides
difficile) 		4 / 6 ASN A  85
GLN A 131
ILE A  99
PHE A  95
 None
 1.07A 2jn3A-4ycsA:
undetectable		 2jn3A-4ycsA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4ycs UNCHARACTERIZED
PROTEIN
(Clostridioides
difficile) 		5 / 11 GLY A 114
ALA A 115
ILE A 136
ALA A  69
ASP A  56
 None
 1.15A 3nmuB-4ycsA:
undetectable
3nmuJ-4ycsA:
3.0		 3nmuB-4ycsA:
14.99
3nmuJ-4ycsA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4ycs UNCHARACTERIZED
PROTEIN
(Clostridioides
difficile) 		5 / 11 TYR A 152
GLY A 114
ALA A 115
ALA A  69
ASP A  56
 GOL  A 201 ( 4.4A)
None
None
None
None
 1.17A 3nmuB-4ycsA:
undetectable
3nmuJ-4ycsA:
3.0		 3nmuB-4ycsA:
14.99
3nmuJ-4ycsA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 4ycs UNCHARACTERIZED
PROTEIN
(Clostridioides
difficile) 		4 / 8 TYR A 140
ILE A 135
ILE A 147
ALA A 125
 None
 0.98A 4ou1A-4ycsA:
2.3		 4ou1A-4ycsA:
18.65