SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ycz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4ycz FUSION PROTEIN OF
SEC13 AND NUP145C
(Thermothelomyces
thermophila) 		4 / 6 LEU A1731
ASP A1725
LEU A1724
GLY A1723
 None
 0.78A 1mt1G-4yczA:
undetectable
1mt1J-4yczA:
undetectable		 1mt1G-4yczA:
4.82
1mt1J-4yczA:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4ycz FUSION PROTEIN OF
SEC13 AND NUP145C
(Thermothelomyces
thermophila) 		4 / 7 LEU A1731
ASP A1725
LEU A1724
GLY A1723
 None
 0.75A 1mt1H-4yczA:
undetectable
1mt1K-4yczA:
undetectable		 1mt1H-4yczA:
8.23
1mt1K-4yczA:
4.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4ycz FUSION PROTEIN OF
SEC13 AND NUP145C
(Thermothelomyces
thermophila) 		4 / 6 LEU A1731
ASP A1725
LEU A1724
GLY A1723
 None
 0.76A 1n13H-4yczA:
undetectable
1n13K-4yczA:
undetectable		 1n13H-4yczA:
8.23
1n13K-4yczA:
4.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4ycz FUSION PROTEIN OF
SEC13 AND NUP145C
(Thermothelomyces
thermophila) 		4 / 7 LEU A1731
ASP A1725
LEU A1724
GLY A1723
 None
 0.77A 1n13G-4yczA:
undetectable
1n13J-4yczA:
undetectable		 1n13G-4yczA:
4.82
1n13J-4yczA:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 4ycz FUSION PROTEIN OF
SEC13 AND NUP145C
(Thermothelomyces
thermophila) 		3 / 3 ALA A 126
VAL A 134
TRP A 197
 None
 0.96A 1w5uA-4yczA:
undetectable
1w5uB-4yczA:
undetectable		 1w5uA-4yczA:
2.51
1w5uB-4yczA:
2.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 4ycz NUP85
(Thermothelomyces
thermophila) 		4 / 7 LEU B 716
LEU B 413
ILE B 420
TRP B 443
 None
 1.16A 2hc4A-4yczB:
undetectable		 2hc4A-4yczB:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_B_HNQB255_1
(CATHEPSIN B)		 4ycz FUSION PROTEIN OF
SEC13 AND NUP145C
(Thermothelomyces
thermophila) 		4 / 6 GLY A  63
HIS A  22
CYH A  36
TRP A  66
 None
 1.46A 3ai8B-4yczA:
undetectable		 3ai8B-4yczA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 4ycz NUP85
(Thermothelomyces
thermophila) 		5 / 12 GLY B 701
ALA B 319
ALA B 322
LEU B 716
TYR B 326
 None
 0.97A 3p2kD-4yczB:
undetectable		 3p2kD-4yczB:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 4ycz FUSION PROTEIN OF
SEC13 AND NUP145C
(Thermothelomyces
thermophila) 		5 / 12 GLU A 294
GLY A 298
SER A 226
VAL A 229
ASN A 278
 None
 1.46A 4ffwA-4yczA:
6.9		 4ffwA-4yczA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_B_FOLB201_0
(FOLATE ECF
TRANSPORTER)		 4ycz FUSION PROTEIN OF
SEC13 AND NUP145C
(Thermothelomyces
thermophila) 		5 / 12 LYS A1271
ASP A  39
ALA A1292
THR A  41
ARG A 270
 None
 1.45A 4z7fB-4yczA:
undetectable		 4z7fB-4yczA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA617_0
(SERUM ALBUMIN)		 4ycz FUSION PROTEIN OF
SEC13 AND NUP145C
(Thermothelomyces
thermophila) 		3 / 3 TRP A  70
ARG A  32
LEU A  58
 None
 0.76A 5dbyA-4yczA:
undetectable		 5dbyA-4yczA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ycz FUSION PROTEIN OF
SEC13 AND NUP145C
(Thermothelomyces
thermophila) 		3 / 3 ARG A 270
VAL A 111
TRP A  66
 None
 1.26A 5fvoA-4yczA:
undetectable		 5fvoA-4yczA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4ycz NUP120
(Thermothelomyces
thermophila) 		3 / 3 LEU C1002
ILE C1033
TYR C1055
 None
 0.54A 5uunB-4yczC:
undetectable		 5uunB-4yczC:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 4ycz FUSION PROTEIN OF
SEC13 AND NUP145C
(Thermothelomyces
thermophila) 		5 / 12 ARG A 100
ILE A  44
ALA A  34
ALA A  80
GLY A  83
 None
 1.09A 5veuA-4yczA:
undetectable		 5veuA-4yczA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_0
(ADENOSYLHOMOCYSTEINA
SE)		 4ycz FUSION PROTEIN OF
SEC13 AND NUP145C
(Thermothelomyces
thermophila) 		5 / 12 ASP A 141
HIS A1670
GLY A1744
HIS A1743
PHE A 139
 None
 1.41A 6exiA-4yczA:
undetectable		 6exiA-4yczA:
7.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4ycz FUSION PROTEIN OF
SEC13 AND NUP145C
NUP120
(Thermothelomyces
thermophila;
Thermothelomyces
thermophila) 		4 / 6 ASP C1126
ARG C1202
ASP A1754
GLU A1757
 None
 1.21A 6mn5D-4yczC:
undetectable		 6mn5D-4yczC:
12.91