SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yd8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 4yd8 PROTEIN PTHB1
(Homo
sapiens) 		4 / 6 VAL A 335
ILE A 345
TRP A 322
LEU A 320
 None
 1.21A 1j96A-4yd8A:
undetectable		 1j96A-4yd8A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 4yd8 PROTEIN PTHB1
(Homo
sapiens) 		4 / 7 GLU A  71
LEU A  68
LEU A  14
GLU A  18
 None
 1.14A 1linA-4yd8A:
undetectable		 1linA-4yd8A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 4yd8 PROTEIN PTHB1
(Homo
sapiens) 		4 / 7 VAL A 318
ILE A 305
GLY A 306
LEU A 326
 None
 0.82A 3bjwB-4yd8A:
undetectable		 3bjwB-4yd8A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_3
(PHOSPHOLIPASE A2)		 4yd8 PROTEIN PTHB1
(Homo
sapiens) 		4 / 7 VAL A 318
ILE A 305
GLY A 306
LEU A 326
 None
 0.82A 3bjwF-4yd8A:
undetectable		 3bjwF-4yd8A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 4yd8 PROTEIN PTHB1
(Homo
sapiens) 		4 / 7 VAL A 318
ILE A 305
GLY A 306
LEU A 326
 None
 0.87A 3bjwH-4yd8A:
undetectable		 3bjwH-4yd8A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 4yd8 PROTEIN PTHB1
(Homo
sapiens) 		4 / 7 ASP A 236
VAL A 260
ILE A 248
SER A 192
 None
 0.95A 3pglA-4yd8A:
undetectable		 3pglA-4yd8A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N1T_W_CUW201_0
(COPC)		 4yd8 PROTEIN PTHB1
(Homo
sapiens) 		3 / 3 HIS A 328
ASP A 351
HIS A 353
 None
 0.72A 5n1tW-4yd8A:
undetectable		 5n1tW-4yd8A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 4yd8 PROTEIN PTHB1
(Homo
sapiens) 		5 / 12 GLY A  43
LEU A  49
GLN A  80
VAL A  78
LEU A  74
 None
 1.18A 5ubbA-4yd8A:
undetectable		 5ubbA-4yd8A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 4yd8 PROTEIN PTHB1
(Homo
sapiens) 		4 / 8 ARG A 278
THR A 303
PRO A 292
ILE A 305
 None
 0.97A 6a4iA-4yd8A:
undetectable		 6a4iA-4yd8A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUO_D_08HD501_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		 4yd8 PROTEIN PTHB1
(Homo
sapiens) 		4 / 8 PHE A 279
PHE A 268
VAL A 251
SER A 259
 None
 1.18A 6huoC-4yd8A:
undetectable
6huoD-4yd8A:
undetectable		 6huoC-4yd8A:
10.83
6huoD-4yd8A:
13.02