SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ydi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 4ydi ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		4 / 8 SER G  56
SER G 115
PHE G 210
ILE G 108
 None
 0.85A 1gm7A-4ydiG:
undetectable
1gm7B-4ydiG:
undetectable		 1gm7A-4ydiG:
17.78
1gm7B-4ydiG:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 4ydi LIGHT CHAIN OF
ANTIBODY
Z258-VRC27.01
(Homo
sapiens) 		4 / 7 LEU L 135
THR L 172
SER L 162
THR L 164
 None
 0.68A 1ictD-4ydiL:
undetectable		 1ictD-4ydiL:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4ydi HEAVY CHAIN OF
ANTIBODY
Z258-VRC27.01
(Homo
sapiens) 		4 / 6 ASP H  86
LEU H  82
GLY H  82
ARG H  66
 None
 0.91A 1mt1G-4ydiH:
undetectable
1mt1J-4ydiH:
undetectable		 1mt1G-4ydiH:
9.78
1mt1J-4ydiH:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 4ydi LIGHT CHAIN OF
ANTIBODY
Z258-VRC27.01
(Homo
sapiens) 		5 / 12 ALA L  51
SER L  52
ALA L  25
ASP L  32
ILE L  29
 None
None
None
NAG  G 504 (-3.4A)
None
 1.02A 1nt2A-4ydiL:
undetectable		 1nt2A-4ydiL:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4ydi LIGHT CHAIN OF
ANTIBODY
Z258-VRC27.01
(Homo
sapiens) 		4 / 5 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.83A 2aojA-4ydiL:
undetectable		 2aojA-4ydiL:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 4ydi ENVELOPE
GLYCOPROTEIN GP160
HEAVY CHAIN OF
ANTIBODY
Z258-VRC27.01
LIGHT CHAIN OF
ANTIBODY
Z258-VRC27.01
(Human
immunodeficiency
virus
1;
Homo
sapiens;
Homo
sapiens) 		3 / 3 SER H 100
GLU L  96
ASP G 457
 None
 0.90A 2avdB-4ydiH:
undetectable		 2avdB-4ydiH:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 4ydi ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 11 LEU G 342
ASN G 339
VAL G 333
LEU G 390
SER G 393
 None
 1.30A 2bxeA-4ydiG:
undetectable		 2bxeA-4ydiG:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2001_1
(SERUM ALBUMIN)		 4ydi ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 12 LEU G 342
ASN G 339
VAL G 333
LEU G 390
SER G 393
 None
 1.17A 2bxeB-4ydiG:
undetectable		 2bxeB-4ydiG:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 4ydi ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 11 LEU G 342
ASN G 339
VAL G 333
LEU G 390
SER G 393
 None
 1.26A 2bxgA-4ydiG:
undetectable		 2bxgA-4ydiG:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 4ydi HEAVY CHAIN OF
ANTIBODY
Z258-VRC27.01
LIGHT CHAIN OF
ANTIBODY
Z258-VRC27.01
(Homo
sapiens;
Homo
sapiens) 		5 / 10 PHE H  45
TYR L  87
THR L  85
GLY L  41
VAL H  89
 None
 1.31A 2cp4A-4ydiH:
undetectable		 2cp4A-4ydiH:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 4ydi ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		4 / 7 LEU G 259
LEU G 453
ILE G 272
SER G 274
 None
 1.24A 2hc4A-4ydiG:
undetectable		 2hc4A-4ydiG:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 4ydi ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 9 THR G 387
LEU G 416
VAL G 333
ILE G 449
VAL G 292
 None
 1.40A 2l8mA-4ydiG:
undetectable		 2l8mA-4ydiG:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4ydi HEAVY CHAIN OF
ANTIBODY
Z258-VRC27.01
(Homo
sapiens) 		4 / 7 ARG H  66
ASP H  86
LEU H  82
GLY H  82
 None
 0.98A 2qqcD-4ydiH:
undetectable
2qqcE-4ydiH:
undetectable		 2qqcD-4ydiH:
15.79
2qqcE-4ydiH:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_1
(REPRESSOR PROTEIN
MPHR(A))		 4ydi ENVELOPE
GLYCOPROTEIN GP160
HEAVY CHAIN OF
ANTIBODY
Z258-VRC27.01
(Human
immunodeficiency
virus
1;
Homo
sapiens) 		4 / 5 ASN G 462
ARG G 456
ASN G 280
ALA H  60
 NAG  G 512 (-4.5A)
None
None
None
 1.23A 3frqA-4ydiG:
undetectable		 3frqA-4ydiG:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 4ydi ENVELOPE
GLYCOPROTEIN GP160
HEAVY CHAIN OF
ANTIBODY
Z258-VRC27.01
(Human
immunodeficiency
virus
1;
Homo
sapiens) 		4 / 7 ASN G 462
ARG G 456
ASN G 280
ALA H  60
 NAG  G 512 (-4.5A)
None
None
None
 1.21A 3frqB-4ydiG:
undetectable		 3frqB-4ydiG:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 4ydi ENVELOPE
GLYCOPROTEIN GP160
HEAVY CHAIN OF
ANTIBODY
Z258-VRC27.01
(Homo
sapiens;
Human
immunodeficiency
virus
1) 		5 / 12 GLY G 235
GLU G 275
ASP H  99
GLY H 100
ASN G 276
 None
None
None
None
NAG  G 504 (-1.8A)
 1.44A 3jzjA-4ydiG:
undetectable		 3jzjA-4ydiG:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ydi LIGHT CHAIN OF
ANTIBODY
Z258-VRC27.01
(Homo
sapiens) 		5 / 10 SER L 171
TYR L 140
LEU L  78
VAL L  19
VAL L  83
 None
 1.50A 3u9fR-4ydiL:
undetectable		 3u9fR-4ydiL:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4ydi ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 12 PHE G 391
ASN G 332
VAL G 292
ILE G 449
LEU G 452
 None
NAG  G 505 (-1.9A)
None
None
None
 1.24A 4k39A-4ydiG:
undetectable		 4k39A-4ydiG:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 4ydi LIGHT CHAIN OF
ANTIBODY
Z258-VRC27.01
(Homo
sapiens) 		3 / 3 ARG L 142
GLN L 166
GLU L 165
 None
 0.75A 4tvtA-4ydiL:
undetectable		 4tvtA-4ydiL:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4ydi ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		4 / 6 PHE G 468
ARG G 350
THR G 357
ILE G 360
 None
None
None
NAG  G 512 (-4.8A)
 1.44A 5ih0A-4ydiG:
undetectable		 5ih0A-4ydiG:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 4ydi ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 12 PHE G 233
GLY G 235
VAL G 101
ILE G 270
GLY G 232
 None
 1.12A 6c2mB-4ydiG:
undetectable		 6c2mB-4ydiG:
12.10