SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ydj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 4ydj HEAVY CHAIN OF
ANTIBODY 44-VRC13.01
LIGHT CHAIN OF
ANTIBODY 44-VRC13.01
(Homo
sapiens) 		5 / 11 ILE H  35
ALA H  93
ARG L  53
GLU H 100
LEU L  46
 None
 1.27A 2v0mA-4ydjH:
undetectable		 2v0mA-4ydjH:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 4ydj HEAVY CHAIN OF
ANTIBODY 44-VRC13.01
LIGHT CHAIN OF
ANTIBODY 44-VRC13.01
(Homo
sapiens) 		5 / 11 ILE H  35
ALA H  93
ARG L  53
GLU H 100
LEU L  46
 None
 1.36A 2v0mD-4ydjH:
undetectable		 2v0mD-4ydjH:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4ydj HEAVY CHAIN OF
ANTIBODY 44-VRC13.01
LIGHT CHAIN OF
ANTIBODY 44-VRC13.01
(Homo
sapiens) 		5 / 10 THR H  58
TYR L  96
GLY H  49
PHE H 100
ILE H  35
 None
 1.50A 2y7pA-4ydjH:
undetectable		 2y7pA-4ydjH:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 4ydj LIGHT CHAIN OF
ANTIBODY 44-VRC13.01
(Homo
sapiens) 		3 / 3 THR L 114
SER L 137
PHE L 118
 None
 0.81A 3d4sA-4ydjL:
undetectable		 3d4sA-4ydjL:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IXL_A_PACA5000_0
(ARYLMALONATE
DECARBOXYLASE)		 4ydj HEAVY CHAIN OF
ANTIBODY 44-VRC13.01
(Homo
sapiens) 		5 / 10 PRO H  75
TYR H  35
VAL H  24
SER H  31
GLY H  30
 None
 1.47A 3ixlA-4ydjH:
undetectable		 3ixlA-4ydjH:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBR_A_ASDA129_1
(STEROID
DELTA-ISOMERASE)		 4ydj HEAVY CHAIN OF
ANTIBODY 44-VRC13.01
LIGHT CHAIN OF
ANTIBODY 44-VRC13.01
(Homo
sapiens) 		5 / 12 PHE H 166
VAL L 195
VAL L 144
PRO L 113
PHE L 139
 None
 1.36A 3nbrA-4ydjH:
undetectable		 3nbrA-4ydjH:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 4ydj HEAVY CHAIN OF
ANTIBODY 44-VRC13.01
LIGHT CHAIN OF
ANTIBODY 44-VRC13.01
(Homo
sapiens) 		5 / 9 PHE L  98
PHE H  35
ILE H  35
GLY H  49
THR H  58
 None
 1.28A 3t3rC-4ydjL:
undetectable		 3t3rC-4ydjL:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 4ydj HEAVY CHAIN OF
ANTIBODY 44-VRC13.01
(Homo
sapiens) 		4 / 5 PHE H  35
ILE H  35
GLY H  49
THR H  58
 None
 0.79A 4ejjC-4ydjH:
undetectable		 4ejjC-4ydjH:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4ydj HEAVY CHAIN OF
ANTIBODY 44-VRC13.01
(Homo
sapiens) 		3 / 3 TYR H 176
PHE H 108
ARG H 110
 None
 1.20A 4g19D-4ydjH:
undetectable		 4g19D-4ydjH:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4ydj HEAVY CHAIN OF
ANTIBODY 44-VRC13.01
LIGHT CHAIN OF
ANTIBODY 44-VRC13.01
(Homo
sapiens) 		4 / 5 TYR L  87
GLY L 101
THR L 102
GLY H 174
 None
 0.92A 5jlcA-4ydjL:
undetectable		 5jlcA-4ydjL:
17.44