SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ydk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 4ydk HEAVY CHAIN OF
ANTIBODY
C38-VRC16.01
LIGHT CHAIN OF
ANTIBODY
C38-VRC16.01
(Homo
sapiens;
Homo
sapiens) 		5 / 12 GLY L  96
PHE L  98
LEU H  45
ASN H 100
PHE H 100
 None
 1.32A 1nw3A-4ydkL:
undetectable		 1nw3A-4ydkL:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_E_RTLE1_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 4ydk HEAVY CHAIN OF
ANTIBODY
C38-VRC16.01
LIGHT CHAIN OF
ANTIBODY
C38-VRC16.01
(Homo
sapiens;
Homo
sapiens) 		5 / 11 VAL H  50
TYR L  36
GLN L  89
HIS L  55
TYR H 100
 None
 1.42A 1qabE-4ydkH:
undetectable		 1qabE-4ydkH:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4ydk LIGHT CHAIN OF
ANTIBODY
C38-VRC16.01
(Homo
sapiens) 		4 / 5 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.86A 2aojA-4ydkL:
undetectable		 2aojA-4ydkL:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4ydk HEAVY CHAIN OF
ANTIBODY
C38-VRC16.01
LIGHT CHAIN OF
ANTIBODY
C38-VRC16.01
(Homo
sapiens) 		5 / 12 PHE H  97
SER L  91
VAL H  50
GLY H  35
ALA H  33
 GOL  H 303 (-4.4A)
None
None
None
None
 1.12A 2x2iA-4ydkH:
undetectable		 2x2iA-4ydkH:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4ydk HEAVY CHAIN OF
ANTIBODY
C38-VRC16.01
LIGHT CHAIN OF
ANTIBODY
C38-VRC16.01
(Homo
sapiens) 		5 / 12 PHE H  97
SER L  91
VAL H  50
GLY H  35
ALA H  33
 GOL  H 303 (-4.4A)
None
None
None
None
 1.20A 2x2iC-4ydkH:
undetectable		 2x2iC-4ydkH:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 4ydk HEAVY CHAIN OF
ANTIBODY
C38-VRC16.01
LIGHT CHAIN OF
ANTIBODY
C38-VRC16.01
(Homo
sapiens) 		4 / 8 VAL H  50
TYR H 100
TYR L  36
VAL H  37
 None
 0.92A 2y05A-4ydkH:
undetectable
2y05B-4ydkH:
undetectable		 2y05A-4ydkH:
21.13
2y05B-4ydkH:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4ydk LIGHT CHAIN OF
ANTIBODY
C38-VRC16.01
(Homo
sapiens) 		3 / 3 SER L 127
GLY L 128
THR L 129
 None
 0.24A 3k9wA-4ydkL:
undetectable		 3k9wA-4ydkL:
24.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 4ydk HEAVY CHAIN OF
ANTIBODY
C38-VRC16.01
(Homo
sapiens) 		5 / 12 VAL H   2
ALA H  24
MET H  34
ARG H  71
VAL H  78
 None
 1.03A 3qxtA-4ydkH:
20.0		 3qxtA-4ydkH:
35.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 4ydk HEAVY CHAIN OF
ANTIBODY
C38-VRC16.01
(Homo
sapiens) 		6 / 12 VAL H   2
LEU H   4
ALA H  24
MET H  34
ARG H  71
VAL H  78
 None
 0.89A 3qxtB-4ydkH:
20.4		 3qxtB-4ydkH:
35.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4ydk HEAVY CHAIN OF
ANTIBODY
C38-VRC16.01
(Homo
sapiens) 		4 / 7 ALA H  88
THR H  87
VAL H 109
GLU H  85
 None
 0.76A 5ecmD-4ydkH:
undetectable		 5ecmD-4ydkH:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4ydk HEAVY CHAIN OF
ANTIBODY
C38-VRC16.01
(Homo
sapiens) 		4 / 7 ALA H  88
THR H  87
VAL H 109
GLU H  85
 None
 0.83A 5ecoD-4ydkH:
undetectable		 5ecoD-4ydkH:
18.02