SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ydl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 4ydl LIGHT CHAIN OF
ANTIBODY
C38-VRC18.02
(Homo
sapiens) 		4 / 7 LEU L 135
THR L 172
SER L 162
THR L 164
 None
 0.67A 1ictD-4ydlL:
undetectable		 1ictD-4ydlL:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4ydl LIGHT CHAIN OF
ANTIBODY
C38-VRC18.02
(Homo
sapiens) 		4 / 5 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.83A 2aojA-4ydlL:
undetectable		 2aojA-4ydlL:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 4ydl HEAVY CHAIN OF
ANTIBODY
C38-VRC18.02
LIGHT CHAIN OF
ANTIBODY
C38-VRC18.02
(Homo
sapiens;
Homo
sapiens) 		5 / 12 HIS H  35
GLY H  95
LEU L  46
GLN L  89
VAL H   2
 None
None
None
None
PCA  H   1 ( 3.3A)
 1.17A 4f84A-4ydlH:
undetectable		 4f84A-4ydlH:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4ydl LIGHT CHAIN OF
ANTIBODY
C38-VRC18.02
(Homo
sapiens) 		4 / 6 LEU L 175
GLU L 143
VAL L 110
ALA L 111
 None
 1.13A 4nkvC-4ydlL:
undetectable		 4nkvC-4ydlL:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4ydl HEAVY CHAIN OF
ANTIBODY
C38-VRC18.02
(Homo
sapiens) 		5 / 12 GLY H  85
LEU H  82
ILE H  34
GLY H 104
THR H  87
 None
 1.01A 4ze2A-4ydlH:
undetectable		 4ze2A-4ydlH:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_B_ADNB302_1
(FLUORINASE)		 4ydl LIGHT CHAIN OF
ANTIBODY
C38-VRC18.02
(Homo
sapiens) 		4 / 6 ASP L 170
THR L 172
TYR L 140
THR L 109
 None
None
None
NAG  L 301 (-4.5A)
 1.36A 5b6iB-4ydlL:
undetectable		 5b6iB-4ydlL:
19.75