SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yds'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4yds FLAGELLA-RELATED
PROTEIN H
(Sulfolobus
acidocaldarius) 		4 / 8 SER A  37
ALA A  38
THR A  55
ILE A  85
 None
 0.66A 1gtnI-4ydsA:
undetectable
1gtnJ-4ydsA:
undetectable		 1gtnI-4ydsA:
18.72
1gtnJ-4ydsA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4yds FLAGELLA-RELATED
PROTEIN H
(Sulfolobus
acidocaldarius) 		3 / 3 ILE A 153
ASP A 117
PHE A  44
 None
 0.60A 1uwjB-4ydsA:
undetectable		 1uwjB-4ydsA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 4yds FLAGELLA-RELATED
PROTEIN H
(Sulfolobus
acidocaldarius) 		3 / 3 ASN A 148
ASP A 142
GLN A 138
 None
 0.77A 3eeyC-4ydsA:
2.4		 3eeyC-4ydsA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 4yds FLAGELLA-RELATED
PROTEIN H
(Sulfolobus
acidocaldarius) 		3 / 3 ASN A 148
ASP A 142
GLN A 138
 None
 0.76A 3eeyD-4ydsA:
3.8		 3eeyD-4ydsA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 4yds FLAGELLA-RELATED
PROTEIN H
(Sulfolobus
acidocaldarius) 		3 / 3 ASN A 148
ASP A 142
GLN A 138
 None
 0.76A 3eeyE-4ydsA:
2.6		 3eeyE-4ydsA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_ACTA402_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 4yds FLAGELLA-RELATED
PROTEIN H
(Sulfolobus
acidocaldarius) 		3 / 3 LYS A  82
TYR A  77
ARG A  80
 None
 1.18A 4gc9A-4ydsA:
undetectable		 4gc9A-4ydsA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4yds FLAGELLA-RELATED
PROTEIN H
(Sulfolobus
acidocaldarius) 		4 / 5 ILE A 126
LEU A 127
GLU A  57
VAL A  53
 None
None
MG  A 902 ( 2.3A)
None
 1.02A 4nkxB-4ydsA:
undetectable		 4nkxB-4ydsA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 4yds FLAGELLA-RELATED
PROTEIN H
(Sulfolobus
acidocaldarius) 		5 / 12 ASP A  11
ILE A  17
PRO A  18
ALA A  21
ILE A  23
 None
 1.21A 4uroC-4ydsA:
undetectable		 4uroC-4ydsA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4yds FLAGELLA-RELATED
PROTEIN H
(Sulfolobus
acidocaldarius) 		4 / 6 ILE A  85
VAL A  41
TYR A  52
VAL A  53
 None
 1.00A 5jwaH-4ydsA:
undetectable		 5jwaH-4ydsA:
18.31