SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ye2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Q23_J_FUAJ711_1 (CHLORAMPHENICOL ACETYLTRANSFERASE)	4ye2	CAPPING ENZYME PROTEIN (Rotavirus A)	5 / 11	TYR A 756 PHE A 705 LEU A 719 PHE A 794 VAL A 770	None	1.38A	1q23J-4ye2A: undetectable	1q23J-4ye2A: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Q23_K_FUAK712_1 (CHLORAMPHENICOL ACETYLTRANSFERASE)	4ye2	CAPPING ENZYME PROTEIN (Rotavirus A)	5 / 10	TYR A 756 PHE A 705 LEU A 719 PHE A 794 VAL A 770	None	1.37A	1q23K-4ye2A: undetectable	1q23K-4ye2A: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UDU_A_CIAA1003_1 (CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE)	4ye2	CAPPING ENZYME PROTEIN (Rotavirus A)	5 / 11	ILE A 798 VAL A 767 LEU A 771 ILE A 795 PHE A 721	None None None A2P A 901 (-3.9A) None	1.28A	1uduA-4ye2A: undetectable	1uduA-4ye2A: 18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EM2_A_SALA503_1 (UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR SAR2349)	4ye2	CAPPING ENZYME PROTEIN (Rotavirus A)	4 / 6	ILE A 731 VAL A 830 LYS A 824 LEU A 822	None	0.94A	4em2A-4ye2A: undetectable	4em2A-4ye2A: 20.96

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1Q23_J_FUAJ711_1","CHLORAMPHENICOL ACETYLTRANSFERASE","4ye2","CAPPING ENZYME PROTEIN","Rotavirus A",5,"TYR A 756;PHE A 705;LEU A 719;PHE A 794;VAL A 770","None","1.38A","1q23J-4ye2A:undetectable","1q23J-4ye2A:20.00"],["1Q23_K_FUAK712_1","CHLORAMPHENICOL ACETYLTRANSFERASE","4ye2","CAPPING ENZYME PROTEIN","Rotavirus A",5,"TYR A 756;PHE A 705;LEU A 719;PHE A 794;VAL A 770","None","1.37A","1q23K-4ye2A:undetectable","1q23K-4ye2A:20.00"],["1UDU_A_CIAA1003_1","CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE","4ye2","CAPPING ENZYME PROTEIN","Rotavirus A",5,"ILE A 798;VAL A 767;LEU A 771;ILE A 795;PHE A 721","None;None;None;A2P A 901 (-3.9A);None","1.28A","1uduA-4ye2A:undetectable","1uduA-4ye2A:18.06"],["4EM2_A_SALA503_1","UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR SAR2349","4ye2","CAPPING ENZYME PROTEIN","Rotavirus A",4,"ILE A 731;VAL A 830;LYS A 824;LEU A 822","None","0.94A","4em2A-4ye2A:undetectable","4em2A-4ye2A:20.96"]]