SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ye4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)		 4ye4 HEAVY CHAIN HUMAN
ANTIBODY HJ16
(Homo
sapiens) 		4 / 8 GLN H   6
VAL H 123
GLY H   8
GLY H   9
 None
 0.90A 1ekjE-4ye4H:
undetectable
1ekjF-4ye4H:
undetectable		 1ekjE-4ye4H:
21.22
1ekjF-4ye4H:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 4ye4 LIGHT CHAIN OF HJ16
(Homo
sapiens) 		4 / 7 LEU L 142
THR L 179
SER L 169
THR L 171
 None
 0.72A 1ictD-4ye4L:
undetectable		 1ictD-4ye4L:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		 4ye4 HEAVY CHAIN HUMAN
ANTIBODY HJ16
HT593.1 GP120
(Homo
sapiens;
Human
immunodeficiency
virus) 		5 / 11 GLY G 458
GLY G 459
PHE H 111
PHE H 102
HIS H 103
 None
 1.30A 1w76A-4ye4G:
undetectable		 1w76A-4ye4G:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4ye4 LIGHT CHAIN OF HJ16
(Homo
sapiens) 		4 / 5 LEU L 186
GLY L 135
PRO L 127
VAL L 139
 None
 0.85A 2aojA-4ye4L:
undetectable		 2aojA-4ye4L:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPZ_A_TYLA2001_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4ye4 LIGHT CHAIN OF HJ16
(Homo
sapiens) 		4 / 6 LEU L 186
ALA L 137
HIS L 196
ASP L 158
 None
 1.23A 2dpzA-4ye4L:
undetectable		 2dpzA-4ye4L:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DXR_A_SORA1002_0
(LACTOTRANSFERRIN)		 4ye4 HT593.1 GP120
(Human
immunodeficiency
virus) 		3 / 3 THR G 257
PRO G 369
TYR G 384
 None
 0.96A 2dxrA-4ye4G:
undetectable		 2dxrA-4ye4G:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6001_0
(PANTOTHENATE KINASE)		 4ye4 HT593.1 GP120
HEAVY CHAIN HUMAN
ANTIBODY HJ16
(Human
immunodeficiency
virus;
Homo
sapiens) 		5 / 11 VAL H 108
GLY G 366
ILE G 371
THR G 455
ARG G 471
 None
 1.29A 2f9wA-4ye4H:
undetectable
2f9wB-4ye4H:
undetectable		 2f9wA-4ye4H:
20.00
2f9wB-4ye4H:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_B_ANWB99_0
(PROTEIN S100-A13)		 4ye4 LIGHT CHAIN OF HJ16
(Homo
sapiens) 		4 / 8 ALA L  73
THR L  79
PHE L  78
ASP L  37
 None
 1.15A 2kotB-4ye4L:
undetectable		 2kotB-4ye4L:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4ye4 LIGHT CHAIN OF HJ16
(Homo
sapiens) 		3 / 3 LEU L  80
TRP L  56
TYR L  42
 None
 0.89A 3aicF-4ye4L:
undetectable		 3aicF-4ye4L:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4ye4 LIGHT CHAIN OF HJ16
(Homo
sapiens) 		3 / 3 LEU L  80
TRP L  56
TYR L  42
 None
 0.89A 3aicG-4ye4L:
undetectable		 3aicG-4ye4L:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4ye4 LIGHT CHAIN OF HJ16
(Homo
sapiens) 		3 / 3 LEU L  80
TRP L  56
TYR L  42
 None
 0.94A 3aicH-4ye4L:
undetectable		 3aicH-4ye4L:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_2
(ADENOSYLHOMOCYSTEINA
SE)		 4ye4 HEAVY CHAIN HUMAN
ANTIBODY HJ16
LIGHT CHAIN OF HJ16
(Homo
sapiens) 		4 / 4 GLN H  99
THR H 100
THR L 101
HIS H  58
 None
 1.49A 3g1uA-4ye4H:
undetectable		 3g1uA-4ye4H:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_2
(ADENOSYLHOMOCYSTEINA
SE)		 4ye4 HEAVY CHAIN HUMAN
ANTIBODY HJ16
LIGHT CHAIN OF HJ16
(Homo
sapiens) 		4 / 5 GLN H  99
THR H 100
THR L 101
HIS H  58
 None
 1.50A 3g1uC-4ye4H:
undetectable		 3g1uC-4ye4H:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 4ye4 HT593.1 GP120
(Human
immunodeficiency
virus) 		5 / 12 ASN G 262
SER G 447
GLU G 211
GLY G 380
ILE G 443
 NAG  G 502 (-1.8A)
NAG  G 502 (-2.8A)
NAG  G 502 (-3.1A)
None
None
 1.36A 3jb2A-4ye4G:
undetectable		 3jb2A-4ye4G:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 4ye4 HT593.1 GP120
(Human
immunodeficiency
virus) 		3 / 3 ASN G 465
ASN G 461
GLU G 468
 None
 0.65A 3kpdC-4ye4G:
undetectable		 3kpdC-4ye4G:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4ye4 HT593.1 GP120
(Human
immunodeficiency
virus) 		3 / 3 ASN G 465
ASN G 461
GLU G 468
 None
 0.74A 3kpdB-4ye4G:
undetectable		 3kpdB-4ye4G:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SOA_A_DB8A445_1
(CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER)		 4ye4 LIGHT CHAIN OF HJ16
(Homo
sapiens) 		4 / 6 LEU L 186
VAL L 139
PHE L 216
VAL L 157
 None
 1.14A 3soaA-4ye4L:
undetectable		 3soaA-4ye4L:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4ye4 HT593.1 GP120
(Human
immunodeficiency
virus) 		5 / 12 GLY G 250
TYR G 217
ALA G  70
PRO G 253
LEU G 111
 None
 1.04A 3tm4A-4ye4G:
undetectable		 3tm4A-4ye4G:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4ye4 HT593.1 GP120
(Human
immunodeficiency
virus) 		5 / 12 GLY G 250
TYR G 217
ALA G  70
PRO G 253
LEU G 111
 None
 1.01A 3tm4B-4ye4G:
undetectable		 3tm4B-4ye4G:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_B_ACRB1_2
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 4ye4 HEAVY CHAIN HUMAN
ANTIBODY HJ16
LIGHT CHAIN OF HJ16
(Homo
sapiens) 		4 / 5 PRO L 103
ILE H 101
TRP L  56
PHE H 114
 None
 1.27A 3topB-4ye4L:
undetectable		 3topB-4ye4L:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 4ye4 HT593.1 GP120
(Human
immunodeficiency
virus) 		3 / 3 SER G 375
PHE G 382
LYS G 421
 None
 0.97A 3u88A-4ye4G:
undetectable		 3u88A-4ye4G:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 4ye4 HT593.1 GP120
LIGHT CHAIN OF HJ16
(Homo
sapiens;
Human
immunodeficiency
virus) 		4 / 6 THR L 101
ASN G 462
GLY G 466
ILE G 469
 None
 0.99A 3w9tF-4ye4L:
undetectable		 3w9tF-4ye4L:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 4ye4 HT593.1 GP120
(Human
immunodeficiency
virus) 		3 / 3 GLN G 203
ASP G 113
GLN G 428
 None
 0.84A 4aztA-4ye4G:
undetectable		 4aztA-4ye4G:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 4ye4 HEAVY CHAIN HUMAN
ANTIBODY HJ16
HT593.1 GP120
LIGHT CHAIN OF HJ16
(Homo
sapiens;
Human
immunodeficiency
virus) 		4 / 8 GLN L  97
ASN G 460
GLN L  96
TRP H  47
 None
 1.39A 4d1yA-4ye4L:
undetectable
4d1yB-4ye4L:
undetectable		 4d1yA-4ye4L:
21.49
4d1yB-4ye4L:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_ACTA402_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 4ye4 LIGHT CHAIN OF HJ16
(Homo
sapiens) 		3 / 3 LYS L  24
TYR L  77
ARG L  76
 None
 1.36A 4gc9A-4ye4L:
undetectable		 4gc9A-4ye4L:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4ye4 HT593.1 GP120
(Human
immunodeficiency
virus) 		5 / 12 PHE G 391
ASN G 332
VAL G 292
ILE G 449
LEU G 452
 None
NAG  G 505 (-4.4A)
None
None
None
 1.36A 4k39A-4ye4G:
undetectable		 4k39A-4ye4G:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4ye4 LIGHT CHAIN OF HJ16
(Homo
sapiens) 		4 / 6 LEU L 182
GLU L 150
VAL L 117
ALA L 118
 None
 1.19A 4nkvC-4ye4L:
undetectable		 4nkvC-4ye4L:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 4ye4 HEAVY CHAIN HUMAN
ANTIBODY HJ16
HT593.1 GP120
(Homo
sapiens;
Human
immunodeficiency
virus) 		4 / 6 GLU H  54
ASP H  98
GLU H  35
ASN G 460
 None
 1.15A 4ntxA-4ye4H:
undetectable
4ntxC-4ye4H:
undetectable		 4ntxA-4ye4H:
18.34
4ntxC-4ye4H:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 4ye4 HT593.1 GP120
(Human
immunodeficiency
virus) 		5 / 9 HIS G  66
LEU G 116
VAL G 208
SER G 209
VAL G  65
 None
 1.20A 4qd3A-4ye4G:
undetectable		 4qd3A-4ye4G:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4ye4 HEAVY CHAIN HUMAN
ANTIBODY HJ16
(Homo
sapiens) 		5 / 11 SER H 202
GLY H 148
THR H 149
ALA H 150
THR H 145
 None
 0.76A 4qvnH-4ye4H:
undetectable
4qvnI-4ye4H:
undetectable		 4qvnH-4ye4H:
24.22
4qvnI-4ye4H:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4ye4 HEAVY CHAIN HUMAN
ANTIBODY HJ16
(Homo
sapiens) 		5 / 10 SER H 202
GLY H 148
THR H 149
ALA H 150
THR H 145
 None
 0.76A 4qvnV-4ye4H:
undetectable
4qvnW-4ye4H:
undetectable		 4qvnV-4ye4H:
24.22
4qvnW-4ye4H:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4ye4 HEAVY CHAIN HUMAN
ANTIBODY HJ16
(Homo
sapiens) 		5 / 12 SER H 202
GLY H 148
THR H 149
ALA H 150
THR H 145
 None
 0.74A 4qvpH-4ye4H:
undetectable
4qvpI-4ye4H:
undetectable		 4qvpH-4ye4H:
24.22
4qvpI-4ye4H:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4ye4 HEAVY CHAIN HUMAN
ANTIBODY HJ16
(Homo
sapiens) 		5 / 12 SER H 202
GLY H 148
THR H 149
ALA H 150
THR H 145
 None
 0.74A 4qvpV-4ye4H:
undetectable
4qvpW-4ye4H:
undetectable		 4qvpV-4ye4H:
24.22
4qvpW-4ye4H:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4ye4 HEAVY CHAIN HUMAN
ANTIBODY HJ16
(Homo
sapiens) 		5 / 11 SER H 202
GLY H 148
THR H 149
ALA H 150
THR H 145
 None
 0.77A 4qvqH-4ye4H:
undetectable
4qvqI-4ye4H:
undetectable		 4qvqH-4ye4H:
24.22
4qvqI-4ye4H:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4ye4 HEAVY CHAIN HUMAN
ANTIBODY HJ16
(Homo
sapiens) 		5 / 11 SER H 202
GLY H 148
THR H 149
ALA H 150
THR H 145
 None
 0.76A 4qvqV-4ye4H:
undetectable
4qvqW-4ye4H:
undetectable		 4qvqV-4ye4H:
24.22
4qvqW-4ye4H:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 4ye4 HEAVY CHAIN HUMAN
ANTIBODY HJ16
(Homo
sapiens) 		5 / 11 SER H 202
GLY H 148
THR H 149
ALA H 150
THR H 145
 None
 0.78A 4qvvH-4ye4H:
undetectable		 4qvvH-4ye4H:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 4ye4 HEAVY CHAIN HUMAN
ANTIBODY HJ16
(Homo
sapiens) 		5 / 11 SER H 202
GLY H 148
THR H 149
ALA H 150
THR H 145
 None
 0.77A 4qvvV-4ye4H:
undetectable		 4qvvV-4ye4H:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 4ye4 HEAVY CHAIN HUMAN
ANTIBODY HJ16
(Homo
sapiens) 		5 / 11 SER H 202
GLY H 148
THR H 149
ALA H 150
THR H 145
 None
 0.76A 4qvyH-4ye4H:
undetectable		 4qvyH-4ye4H:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4ye4 HEAVY CHAIN HUMAN
ANTIBODY HJ16
(Homo
sapiens) 		5 / 12 SER H 202
GLY H 148
THR H 149
ALA H 150
THR H 145
 None
 0.76A 4qvyV-4ye4H:
undetectable
4qvyW-4ye4H:
undetectable		 4qvyV-4ye4H:
24.22
4qvyW-4ye4H:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4ye4 HEAVY CHAIN HUMAN
ANTIBODY HJ16
(Homo
sapiens) 		5 / 11 SER H 202
GLY H 148
THR H 149
ALA H 150
THR H 145
 None
 0.76A 4qw0H-4ye4H:
undetectable
4qw0I-4ye4H:
undetectable		 4qw0H-4ye4H:
24.22
4qw0I-4ye4H:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4ye4 HEAVY CHAIN HUMAN
ANTIBODY HJ16
(Homo
sapiens) 		5 / 11 SER H 202
GLY H 148
THR H 149
ALA H 150
THR H 145
 None
 0.76A 4qw0V-4ye4H:
undetectable
4qw0W-4ye4H:
undetectable		 4qw0V-4ye4H:
24.22
4qw0W-4ye4H:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4ye4 HEAVY CHAIN HUMAN
ANTIBODY HJ16
(Homo
sapiens) 		5 / 12 SER H 202
GLY H 148
THR H 149
ALA H 150
THR H 145
 None
 0.77A 4qw1H-4ye4H:
undetectable
4qw1I-4ye4H:
undetectable		 4qw1H-4ye4H:
24.22
4qw1I-4ye4H:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4ye4 HEAVY CHAIN HUMAN
ANTIBODY HJ16
(Homo
sapiens) 		5 / 12 SER H 202
GLY H 148
THR H 149
ALA H 150
THR H 145
 None
 0.77A 4qw1V-4ye4H:
undetectable
4qw1W-4ye4H:
undetectable		 4qw1V-4ye4H:
24.22
4qw1W-4ye4H:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4ye4 HEAVY CHAIN HUMAN
ANTIBODY HJ16
(Homo
sapiens) 		5 / 11 SER H 202
GLY H 148
THR H 149
ALA H 150
THR H 145
 None
 0.76A 4qwuH-4ye4H:
undetectable
4qwuI-4ye4H:
undetectable		 4qwuH-4ye4H:
24.22
4qwuI-4ye4H:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4ye4 HEAVY CHAIN HUMAN
ANTIBODY HJ16
(Homo
sapiens) 		5 / 11 SER H 202
GLY H 148
THR H 149
ALA H 150
THR H 145
 None
 0.76A 4qwuV-4ye4H:
undetectable
4qwuW-4ye4H:
undetectable		 4qwuV-4ye4H:
24.22
4qwuW-4ye4H:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 4ye4 HT593.1 GP120
HEAVY CHAIN HUMAN
ANTIBODY HJ16
(Human
immunodeficiency
virus;
Homo
sapiens) 		5 / 12 GLY G 474
SER G 256
ASN H 105
SER G 365
GLN G 362
 None
 1.23A 4rtpA-4ye4G:
undetectable		 4rtpA-4ye4G:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 4ye4 HEAVY CHAIN HUMAN
ANTIBODY HJ16
HT593.1 GP120
(Homo
sapiens;
Human
immunodeficiency
virus) 		4 / 7 GLY G 459
TYR H 113
PHE H 111
ASN G 460
 None
 1.06A 4ws0A-4ye4G:
undetectable		 4ws0A-4ye4G:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_B_ADNB302_1
(FLUORINASE)		 4ye4 LIGHT CHAIN OF HJ16
(Homo
sapiens) 		4 / 6 ASP L 177
THR L 179
TYR L 147
THR L 116
 None
 1.36A 5b6iB-4ye4L:
undetectable		 5b6iB-4ye4L:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4ye4 HEAVY CHAIN HUMAN
ANTIBODY HJ16
(Homo
sapiens) 		5 / 11 SER H 202
GLY H 148
THR H 149
ALA H 150
THR H 145
 None
 0.78A 5bxnH-4ye4H:
undetectable
5bxnI-4ye4H:
undetectable		 5bxnH-4ye4H:
24.22
5bxnI-4ye4H:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4ye4 HEAVY CHAIN HUMAN
ANTIBODY HJ16
(Homo
sapiens) 		5 / 12 SER H 202
GLY H 148
THR H 149
ALA H 150
THR H 145
 None
 0.76A 5cz7V-4ye4H:
undetectable
5cz7W-4ye4H:
undetectable		 5cz7V-4ye4H:
24.22
5cz7W-4ye4H:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 4ye4 HEAVY CHAIN HUMAN
ANTIBODY HJ16
(Homo
sapiens) 		5 / 11 SER H 202
GLY H 148
THR H 149
ALA H 150
THR H 145
 None
 0.75A 5d0xV-4ye4H:
undetectable		 5d0xV-4ye4H:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 4ye4 HT593.1 GP120
(Human
immunodeficiency
virus) 		3 / 3 TYR G 488
LYS G 487
LYS G 227
 None
 1.28A 5dbyA-4ye4G:
undetectable		 5dbyA-4ye4G:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 4ye4 HT593.1 GP120
LIGHT CHAIN OF HJ16
(Human
immunodeficiency
virus;
Homo
sapiens) 		4 / 6 PRO L  33
GLY G 459
ARG L  99
ARG G 456
 NAG  G 503 (-3.8A)
None
None
None
 1.44A 5jcnB-4ye4L:
undetectable		 5jcnB-4ye4L:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4ye4 HT593.1 GP120
(Human
immunodeficiency
virus) 		4 / 5 PHE G 470
ILE G 359
GLN G 352
ARG G 456
 None
 0.80A 5jm4A-4ye4G:
undetectable		 5jm4A-4ye4G:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4ye4 HT593.1 GP120
(Human
immunodeficiency
virus) 		4 / 4 PHE G 470
ILE G 359
GLN G 352
ARG G 456
 None
 0.83A 5jm4B-4ye4G:
undetectable		 5jm4B-4ye4G:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4ye4 HEAVY CHAIN HUMAN
ANTIBODY HJ16
(Homo
sapiens) 		5 / 12 SER H 202
GLY H 148
THR H 149
ALA H 150
THR H 145
 None
 0.73A 5l5fH-4ye4H:
undetectable
5l5fI-4ye4H:
undetectable		 5l5fH-4ye4H:
24.22
5l5fI-4ye4H:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4ye4 HEAVY CHAIN HUMAN
ANTIBODY HJ16
(Homo
sapiens) 		5 / 12 SER H 202
GLY H 148
THR H 149
ALA H 150
THR H 145
 None
 0.73A 5l5fV-4ye4H:
undetectable
5l5fW-4ye4H:
undetectable		 5l5fV-4ye4H:
24.22
5l5fW-4ye4H:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4ye4 HEAVY CHAIN HUMAN
ANTIBODY HJ16
(Homo
sapiens) 		5 / 12 SER H 202
GLY H 148
THR H 149
ALA H 150
THR H 145
 None
 0.76A 5l66H-4ye4H:
undetectable
5l66I-4ye4H:
undetectable		 5l66H-4ye4H:
24.22
5l66I-4ye4H:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4ye4 HEAVY CHAIN HUMAN
ANTIBODY HJ16
(Homo
sapiens) 		5 / 12 SER H 202
GLY H 148
THR H 149
ALA H 150
THR H 145
 None
 0.76A 5l66V-4ye4H:
undetectable
5l66W-4ye4H:
undetectable		 5l66V-4ye4H:
24.22
5l66W-4ye4H:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 4ye4 HT593.1 GP120
(Human
immunodeficiency
virus) 		4 / 6 PHE G 470
LEU G 452
ARG G 471
GLY G 473
 None
 1.02A 5o4yA-4ye4G:
undetectable		 5o4yA-4ye4G:
7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_H_BO2H301_0
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4ye4 HEAVY CHAIN HUMAN
ANTIBODY HJ16
(Homo
sapiens) 		5 / 12 SER H 202
GLY H 148
THR H 149
ALA H 150
THR H 145
 None
 0.87A 6hwdH-4ye4H:
undetectable
6hwdI-4ye4H:
undetectable		 6hwdH-4ye4H:
21.18
6hwdI-4ye4H:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_V_BO2V301_0
(PROTEASOME SUBUNIT
BETA TYPE-2)		 4ye4 HEAVY CHAIN HUMAN
ANTIBODY HJ16
(Homo
sapiens) 		5 / 11 SER H 202
GLY H 148
THR H 149
ALA H 150
THR H 145
 None
 0.87A 6hwdV-4ye4H:
undetectable		 6hwdV-4ye4H:
21.18