SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yeb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 4yeb FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3
(Mus
musculus) 		5 / 12 ILE B  52
LEU B 102
PRO B 103
VAL B 106
LEU B 109
 None
 0.84A 1df7A-4yebB:
undetectable		 1df7A-4yebB:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 4yeb FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3
(Mus
musculus) 		4 / 5 TYR B  91
LEU B 102
THR B  62
ARG B  87
 None
 1.38A 1i2wA-4yebB:
undetectable		 1i2wA-4yebB:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		 4yeb FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3
(Mus
musculus) 		5 / 12 LEU B 211
LEU B 232
ASN B 235
GLN B 255
LEU B 204
 None
 1.40A 1sqnA-4yebB:
undetectable		 1sqnA-4yebB:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)		 4yeb FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3
(Mus
musculus) 		4 / 8 MET B 333
ARG B 317
PRO B 337
VAL B 340
 None
 1.09A 2qd2A-4yebB:
undetectable		 2qd2A-4yebB:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 4yeb FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3
(Mus
musculus) 		5 / 12 LEU B 180
LEU B 201
LEU B 249
PRO B 245
VAL B 220
 None
 1.36A 2qd4A-4yebB:
undetectable		 2qd4A-4yebB:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		 4yeb FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3
(Mus
musculus) 		5 / 12 LEU B 211
LEU B 232
ASN B 235
GLN B 255
LEU B 204
 None
 1.43A 2w8yB-4yebB:
undetectable		 2w8yB-4yebB:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 4yeb FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3
(Mus
musculus) 		5 / 12 LEU B 211
LEU B 232
ASN B 235
GLN B 255
LEU B 204
 None
 1.42A 3d90A-4yebB:
undetectable		 3d90A-4yebB:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 4yeb FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3
(Mus
musculus) 		5 / 9 PHE B 150
LEU B 135
VAL B 140
LEU B 124
ILE B 119
 None
 0.98A 3tbgD-4yebB:
undetectable		 3tbgD-4yebB:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4yeb FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3
(Mus
musculus) 		4 / 6 ILE B 190
VAL B 205
SER B 194
ASP B 184
 None
 1.09A 4iaqA-4yebB:
undetectable		 4iaqA-4yebB:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_D_LOCD502_1
(TUBULIN BETA CHAIN)		 4yeb FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3
(Mus
musculus) 		5 / 12 LEU B 180
LEU B 227
LEU B 195
ASN B 223
ILE B 190
 None
 1.16A 4x1iD-4yebB:
undetectable		 4x1iD-4yebB:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)		 4yeb FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3
(Mus
musculus) 		5 / 10 ILE B 177
PRO B 174
LEU B 159
VAL B 140
LEU B 204
 None
 1.11A 5ienB-4yebB:
undetectable		 5ienB-4yebB:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 4yeb FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3
(Mus
musculus) 		5 / 12 LEU B 180
LEU B 133
LEU B 161
ASN B 138
ILE B 145
 None
 1.23A 5nm5B-4yebB:
undetectable		 5nm5B-4yebB:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAH_C_RFPC3001_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 4yeb FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3
(Mus
musculus) 		5 / 12 ARG B 234
LEU B 232
LEU B 204
PRO B 170
ILE B 169
 None
 1.20A 5uahC-4yebB:
undetectable		 5uahC-4yebB:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4yeb FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3
(Mus
musculus) 		5 / 9 LEU B 130
LEU B  83
VAL B 106
LEU B 111
ILE B  52
 None
 0.95A 5vkqC-4yebB:
undetectable
5vkqD-4yebB:
undetectable		 5vkqC-4yebB:
12.40
5vkqD-4yebB:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 4yeb FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3
(Mus
musculus) 		4 / 8 LEU B  90
VAL B 106
LEU B 109
ILE B 127
 None
 0.83A 6cb4A-4yebB:
undetectable		 6cb4A-4yebB:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 4yeb FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3
(Mus
musculus) 		4 / 5 LEU B 195
LEU B 232
THR B 189
ARG B 163
 None
 1.01A 6ew0F-4yebB:
undetectable		 6ew0F-4yebB:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 4yeb FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3
(Mus
musculus) 		4 / 6 LEU B 195
LEU B 232
THR B 189
ARG B 163
 None
 1.01A 6ew0G-4yebB:
undetectable		 6ew0G-4yebB:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 4yeb FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3
(Mus
musculus) 		4 / 6 LEU B 102
LEU B 133
SER B 123
ASN B 138
 None
 0.91A 6f88B-4yebB:
undetectable		 6f88B-4yebB:
11.75