SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yef'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DED_A_QPSA2001_1 (CYCLODEXTRIN GLUCANOTRANSFERASE)	4yef	5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1 (Rattus norvegicus)	4 / 6	TRP A 100 LYS A 126 TRP A 133 ASN A 150	4CQ A 201 (-3.8A) 4CQ A 201 (-2.8A) 4CQ A 201 (-4.0A) 4CQ A 201 (-2.9A)	0.34A	1dedA-4yefA: 6.8	1dedA-4yefA: 8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4CP4_A_CAMA416_0 (CYTOCHROME P450-CAM)	4yef	5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1 (Rattus norvegicus)	4 / 7	TYR A 125 THR A 134 VAL A 91 VAL A 129	None	0.89A	4cp4A-4yefA: undetectable	4cp4A-4yefA: 12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HNX_B_TA1B902_1 (TUBULIN BETA-2B CHAIN)	4yef	5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1 (Rattus norvegicus)	5 / 12	LEU A 103 PHE A 97 LEU A 116 THR A 80 ARG A 83	None	1.37A	5hnxB-4yefA: undetectable	5hnxB-4yefA: 12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HLP_A_GAWA1501_0 (SUBSTANCE-P RECEPTOR,SUBSTANCE-P RECEPTOR)	4yef	5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1 (Rattus norvegicus)	5 / 12	PRO A 140 ILE A 141 ILE A 152 VAL A 149 PHE A 127	None	1.15A	6hlpA-4yefA: undetectable	6hlpA-4yefA: 10.76

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1DED_A_QPSA2001_1","CYCLODEXTRIN GLUCANOTRANSFERASE","4yef","5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1","Rattus norvegicus",4,"TRP A 100;LYS A 126;TRP A 133;ASN A 150","4CQ A 201 (-3.8A);4CQ A 201 (-2.8A);4CQ A 201 (-4.0A);4CQ A 201 (-2.9A)","0.34A","1dedA-4yefA:6.8","1dedA-4yefA:8.91"],["4CP4_A_CAMA416_0","CYTOCHROME P450-CAM","4yef","5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1","Rattus norvegicus",4,"TYR A 125;THR A 134;VAL A  91;VAL A 129","None","0.89A","4cp4A-4yefA:undetectable","4cp4A-4yefA:12.76"],["5HNX_B_TA1B902_1","TUBULIN BETA-2B CHAIN","4yef","5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1","Rattus norvegicus",5,"LEU A 103;PHE A  97;LEU A 116;THR A  80;ARG A  83","None","1.37A","5hnxB-4yefA:undetectable","5hnxB-4yefA:12.70"],["6HLP_A_GAWA1501_0","SUBSTANCE-P RECEPTOR,SUBSTANCE-P RECEPTOR","4yef","5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1","Rattus norvegicus",5,"PRO A 140;ILE A 141;ILE A 152;VAL A 149;PHE A 127","None","1.15A","6hlpA-4yefA:undetectable","6hlpA-4yefA:10.76"]]