SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yep'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4yep LAMININ SUBUNIT
ALPHA-2
(Homo
sapiens) 		5 / 12 PHE A1329
GLY A1250
ALA A1248
ILE A1339
ILE A1275
 None
None
None
None
EDO  A1405 ( 3.6A)
 1.07A 3ld6A-4yepA:
undetectable		 3ld6A-4yepA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4yep LAMININ SUBUNIT
ALPHA-2
(Homo
sapiens) 		5 / 12 PHE A1329
GLY A1251
ALA A1248
ILE A1339
ILE A1275
 None
None
None
None
EDO  A1405 ( 3.6A)
 1.35A 3ld6A-4yepA:
undetectable		 3ld6A-4yepA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD393_1
(TETX2 PROTEIN)		 4yep LAMININ SUBUNIT
ALPHA-2
(Homo
sapiens) 		4 / 5 ILE A1286
ILE A1339
TYR A1338
GLU A1242
 EDO  A1405 (-3.9A)
None
EDO  A1405 (-4.6A)
None
 1.25A 4a99D-4yepA:
undetectable		 4a99D-4yepA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 4yep LAMININ SUBUNIT
ALPHA-2
(Homo
sapiens) 		5 / 12 GLY A1278
ILE A1276
PHE A1241
MET A1359
ILE A1357
 None
None
None
None
EDO  A1409 ( 2.5A)
 1.05A 4pd4C-4yepA:
undetectable		 4pd4C-4yepA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNU_A_BEZA319_0
(SHKAI2IB)		 4yep LAMININ SUBUNIT
ALPHA-2
(Homo
sapiens) 		4 / 5 GLN A1273
ILE A1341
ILE A1339
TYR A1255
 EDO  A1401 (-3.1A)
None
None
None
 0.99A 5dnuA-4yepA:
undetectable		 5dnuA-4yepA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)		 4yep LAMININ SUBUNIT
ALPHA-2
(Homo
sapiens) 		4 / 5 GLN A1273
ILE A1341
ILE A1339
TYR A1255
 EDO  A1401 (-3.1A)
None
None
None
 0.97A 5dnvA-4yepA:
undetectable		 5dnvA-4yepA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4yep LAMININ SUBUNIT
ALPHA-2
(Homo
sapiens) 		3 / 3 GLY A1315
THR A1344
PRO A1272
 None
 0.50A 5v5zA-4yepA:
undetectable		 5v5zA-4yepA:
15.12