SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yeq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4yeq LAMININ SUBUNIT
ALPHA-2
(Homo
sapiens) 		5 / 12 PHE U 154
GLY U  75
ALA U  73
ILE U 164
ILE U 100
 None
 0.89A 3ld6A-4yeqU:
undetectable		 3ld6A-4yeqU:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 4yeq LAMININ SUBUNIT
ALPHA-2
(Homo
sapiens) 		5 / 12 ILE U 182
ILE U  19
LEU U  22
VAL U  23
ILE U 179
 None
 1.04A 4m2xG-4yeqU:
undetectable		 4m2xG-4yeqU:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 4yeq LAMININ SUBUNIT
ALPHA-2
(Homo
sapiens) 		5 / 12 GLY U 103
ILE U 101
PHE U  66
MET U 184
ILE U 182
 None
 0.98A 4pd4C-4yeqU:
undetectable		 4pd4C-4yeqU:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 4yeq LAMININ SUBUNIT
ALPHA-2
(Homo
sapiens) 		3 / 3 ASP U 141
ARG U 147
TYR U 138
 None
 0.71A 5a7mA-4yeqU:
undetectable		 5a7mA-4yeqU:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 4yeq LAMININ SUBUNIT
ALPHA-2
(Homo
sapiens) 		3 / 3 ASP U 141
ARG U 147
TYR U 138
 None
 0.72A 5a7mB-4yeqU:
undetectable		 5a7mB-4yeqU:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNU_A_BEZA319_0
(SHKAI2IB)		 4yeq LAMININ SUBUNIT
ALPHA-2
(Homo
sapiens) 		4 / 5 GLN U  98
ILE U 166
ILE U 164
TYR U  80
 None
 0.97A 5dnuA-4yeqU:
undetectable		 5dnuA-4yeqU:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)		 4yeq LAMININ SUBUNIT
ALPHA-2
(Homo
sapiens) 		4 / 5 GLN U  98
ILE U 166
ILE U 164
TYR U  80
 None
 0.95A 5dnvA-4yeqU:
undetectable		 5dnvA-4yeqU:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4yeq LAMININ SUBUNIT
ALPHA-2
(Homo
sapiens) 		3 / 3 GLY U 140
THR U 169
PRO U  97
 None
 0.57A 5v5zA-4yeqU:
undetectable		 5v5zA-4yeqU:
18.01