SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yer'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 4yer ABC TRANSPORTER
ATP-BINDING PROTEIN
(Thermotoga
maritima) 		5 / 10 GLU A 198
ALA A 199
LEU A 191
PRO A 162
ALA A  34
 None
 1.26A 1mjqG-4yerA:
undetectable
1mjqH-4yerA:
undetectable		 1mjqG-4yerA:
15.95
1mjqH-4yerA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_B_BEZB882_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 4yer ABC TRANSPORTER
ATP-BINDING PROTEIN
(Thermotoga
maritima) 		5 / 12 LEU A 159
GLY A  80
ILE A 146
HIS A 152
HIS A 101
 None
 1.25A 1tmxB-4yerA:
undetectable		 1tmxB-4yerA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 4yer ABC TRANSPORTER
ATP-BINDING PROTEIN
(Thermotoga
maritima) 		4 / 5 LEU A 159
PRO A 162
LEU A 191
ILE A 189
 None
 0.84A 2qd4A-4yerA:
undetectable		 2qd4A-4yerA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 4yer ABC TRANSPORTER
ATP-BINDING PROTEIN
(Thermotoga
maritima) 		5 / 9 TYR A 105
GLY A 106
GLY A 102
HIS A 101
ILE A 151
 None
 1.35A 2v7bB-4yerA:
undetectable		 2v7bB-4yerA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 4yer ABC TRANSPORTER
ATP-BINDING PROTEIN
(Thermotoga
maritima) 		5 / 12 CYH A 251
HIS A 300
TYR A 233
LEU A 254
LEU A 259
 None
 1.24A 3okxB-4yerA:
undetectable		 3okxB-4yerA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 4yer ABC TRANSPORTER
ATP-BINDING PROTEIN
(Thermotoga
maritima) 		3 / 3 HIS A 152
HIS A 101
ILE A 151
 None
 0.73A 3u52A-4yerA:
undetectable
3u52C-4yerA:
undetectable		 3u52A-4yerA:
21.08
3u52C-4yerA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 4yer ABC TRANSPORTER
ATP-BINDING PROTEIN
(Thermotoga
maritima) 		5 / 12 VAL A  27
ILE A  47
LEU A  10
VAL A   7
PHE A 190
 None
 1.23A 5im2A-4yerA:
undetectable		 5im2A-4yerA:
21.92