SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yf6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 4yf6 BETA-CARBONIC
ANHYDRASE 1
(Mycobacterium
tuberculosis) 		4 / 8 ASP A  37
HIS A  88
CYH A  91
GLY A  92
 ZN  A 200 ( 4.4A)
ZN  A 200 (-3.4A)
ZN  A 200 (-2.3A)
ZN  A 200 ( 4.7A)
 0.29A 1ekjA-4yf6A:
13.2
1ekjB-4yf6A:
13.4		 1ekjA-4yf6A:
23.29
1ekjB-4yf6A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 4yf6 BETA-CARBONIC
ANHYDRASE 1
(Mycobacterium
tuberculosis) 		4 / 8 ASP A  37
HIS A  88
CYH A  91
GLY A  92
 ZN  A 200 ( 4.4A)
ZN  A 200 (-3.4A)
ZN  A 200 (-2.3A)
ZN  A 200 ( 4.7A)
 0.34A 1ekjA-4yf6A:
13.2
1ekjB-4yf6A:
13.4		 1ekjA-4yf6A:
23.29
1ekjB-4yf6A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 4yf6 BETA-CARBONIC
ANHYDRASE 1
(Mycobacterium
tuberculosis) 		4 / 8 ASP A  37
HIS A  88
CYH A  91
GLY A  92
 ZN  A 200 ( 4.4A)
ZN  A 200 (-3.4A)
ZN  A 200 (-2.3A)
ZN  A 200 ( 4.7A)
 0.28A 1ekjG-4yf6A:
13.5
1ekjH-4yf6A:
13.8		 1ekjG-4yf6A:
23.29
1ekjH-4yf6A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 4yf6 BETA-CARBONIC
ANHYDRASE 1
(Mycobacterium
tuberculosis) 		4 / 5 LEU A  71
ILE A 134
LEU A 131
SER A 130
 None
 0.82A 2byoA-4yf6A:
undetectable		 2byoA-4yf6A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 4yf6 BETA-CARBONIC
ANHYDRASE 1
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  46
LEU A  85
GLY A 148
VAL A  33
ALA A  34
 None
 1.16A 2kceB-4yf6A:
undetectable		 2kceB-4yf6A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 4yf6 BETA-CARBONIC
ANHYDRASE 1
(Mycobacterium
tuberculosis) 		4 / 8 ARG A 133
TYR A 120
GLU A 118
HIS A  87
 None
 1.43A 3zmdA-4yf6A:
undetectable
3zmdB-4yf6A:
undetectable		 3zmdA-4yf6A:
22.80
3zmdB-4yf6A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 4yf6 BETA-CARBONIC
ANHYDRASE 1
(Mycobacterium
tuberculosis) 		4 / 8 GLY A  60
SER A 130
ASN A  58
HIS A  87
 ZN  A 200 ( 4.3A)
None
None
None
 1.01A 4wryA-4yf6A:
2.3		 4wryA-4yf6A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 4yf6 BETA-CARBONIC
ANHYDRASE 1
(Mycobacterium
tuberculosis) 		4 / 8 GLY A  60
SER A 130
ASN A  58
HIS A  87
 ZN  A 200 ( 4.3A)
None
None
None
 1.03A 4wrzA-4yf6A:
2.2		 4wrzA-4yf6A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 4yf6 BETA-CARBONIC
ANHYDRASE 1
(Mycobacterium
tuberculosis) 		4 / 8 GLY A  60
SER A 130
ASN A  58
HIS A  87
 ZN  A 200 ( 4.3A)
None
None
None
 0.97A 4ws1A-4yf6A:
undetectable		 4ws1A-4yf6A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNU_A_BEZA319_0
(SHKAI2IB)		 4yf6 BETA-CARBONIC
ANHYDRASE 1
(Mycobacterium
tuberculosis) 		4 / 5 GLN A  75
HIS A  54
ILE A  83
ILE A  30
 None
 1.17A 5dnuA-4yf6A:
2.0		 5dnuA-4yf6A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)		 4yf6 BETA-CARBONIC
ANHYDRASE 1
(Mycobacterium
tuberculosis) 		4 / 5 GLN A  75
HIS A  54
ILE A  83
ILE A  30
 None
 1.13A 5dnvA-4yf6A:
2.8		 5dnvA-4yf6A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 4yf6 BETA-CARBONIC
ANHYDRASE 1
(Mycobacterium
tuberculosis) 		5 / 11 ILE A  83
LEU A  46
LEU A  85
GLY A 148
ALA A  34
 None
 1.22A 6r2eF-4yf6A:
undetectable		 6r2eF-4yf6A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 4yf6 BETA-CARBONIC
ANHYDRASE 1
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  83
LEU A  46
LEU A  85
GLY A 148
ALA A  34
 None
 1.17A 6r2eH-4yf6A:
undetectable		 6r2eH-4yf6A:
20.80