SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yfa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		3 / 3 VAL C 340
VAL C 335
TRP C 550
 None
 0.98A 1av2C-4yfaC:
undetectable
1av2D-4yfaC:
undetectable		 1av2C-4yfaC:
3.66
1av2D-4yfaC:
3.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD8_0
(GRAMICIDIN A)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		3 / 3 TRP C 168
VAL C 195
TRP C  66
 None
 0.99A 1c4dC-4yfaC:
undetectable
1c4dD-4yfaC:
undetectable		 1c4dC-4yfaC:
3.66
1c4dD-4yfaC:
3.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7;
Acidovorax
sp.
MR-S7) 		6 / 12 ILE A 172
LEU A  78
SER A 166
HIS C 125
TYR A 157
ILE A  94
 None
 1.34A 1fmlB-4yfaA:
undetectable		 1fmlB-4yfaA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		5 / 12 THR C  72
SER C  71
PHE C 297
SER C 280
LEU C 290
 None
 1.26A 1q23B-4yfaC:
undetectable		 1q23B-4yfaC:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		5 / 12 THR C  72
SER C  71
PHE C 297
SER C 280
LEU C 290
 None
 1.33A 1q23C-4yfaC:
undetectable		 1q23C-4yfaC:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		5 / 12 THR C  72
SER C  71
PHE C 297
SER C 280
LEU C 290
 None
 1.31A 1q23D-4yfaC:
undetectable
1q23E-4yfaC:
undetectable		 1q23D-4yfaC:
17.97
1q23E-4yfaC:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		5 / 10 THR C  72
SER C  71
PHE C 297
SER C 280
LEU C 290
 None
 1.35A 1q23E-4yfaC:
undetectable		 1q23E-4yfaC:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		5 / 11 THR C  72
SER C  71
PHE C 297
SER C 280
LEU C 290
 None
 1.29A 1q23F-4yfaC:
undetectable		 1q23F-4yfaC:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		5 / 11 THR C  72
SER C  71
PHE C 297
SER C 280
LEU C 290
 None
 1.28A 1q23I-4yfaC:
undetectable		 1q23I-4yfaC:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_1
(ESTROGEN RECEPTOR
BETA)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		5 / 12 ALA A  98
GLU A  97
ILE A 172
ILE C 151
LEU A 161
 None
 0.98A 1qknA-4yfaA:
undetectable		 1qknA-4yfaA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		3 / 3 SER A  63
GLY A  68
ARG C 121
 None
 0.67A 1t9wA-4yfaA:
undetectable		 1t9wA-4yfaA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		3 / 3 VAL C 340
VAL C 335
TRP C 550
 None
 0.93A 1w5uC-4yfaC:
undetectable
1w5uD-4yfaC:
undetectable		 1w5uC-4yfaC:
3.66
1w5uD-4yfaC:
3.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		4 / 7 VAL C 335
VAL C 511
TRP C 550
GLU C 338
 None
 1.15A 1zzrA-4yfaC:
undetectable
1zzrB-4yfaC:
undetectable		 1zzrA-4yfaC:
21.42
1zzrB-4yfaC:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2003_1
(SERUM ALBUMIN)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		5 / 10 ARG A  62
ILE A 147
ARG A  59
PHE A 117
GLY C  52
 None
 1.11A 2bxqA-4yfaA:
undetectable		 2bxqA-4yfaA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		4 / 8 GLY C   7
THR C   8
ALA C   9
ALA C  10
 None
 0.57A 2ej3A-4yfaC:
undetectable		 2ej3A-4yfaC:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		5 / 12 ILE C 187
ILE C 207
ALA C 185
ARG C 160
ILE C 296
 None
 1.08A 2h79A-4yfaC:
undetectable		 2h79A-4yfaC:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HTQ_A_ZMRA472_1
(NEURAMINIDASE)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		5 / 12 GLU C 400
ARG C 404
ARG C 457
TYR C 481
TYR C 496
 None
 1.39A 2htqA-4yfaC:
undetectable		 2htqA-4yfaC:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		3 / 3 VAL C 335
TRP C 550
VAL C 340
 None
 0.86A 2izqA-4yfaC:
undetectable
2izqB-4yfaC:
undetectable		 2izqA-4yfaC:
3.66
2izqB-4yfaC:
3.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		3 / 3 PRO C 188
ASN C 158
ARG C 160
 None
 1.01A 2qeuB-4yfaC:
undetectable		 2qeuB-4yfaC:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		4 / 6 SER C 392
VAL C 345
TYR C 481
ASP C 385
 None
 1.25A 2x45A-4yfaC:
undetectable		 2x45A-4yfaC:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		4 / 7 SER C 392
VAL C 345
TYR C 481
ASP C 385
 None
 1.24A 2x45B-4yfaC:
undetectable		 2x45B-4yfaC:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		4 / 7 SER C 392
VAL C 345
TYR C 481
ASP C 385
 None
 1.23A 2x45C-4yfaC:
undetectable		 2x45C-4yfaC:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		5 / 12 GLY C  52
SER C  49
ILE C  56
LEU C  37
MET A 113
 None
 1.11A 3adsB-4yfaC:
undetectable		 3adsB-4yfaC:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAZ_A_AINA1202_1
(LACTOTRANSFERRIN)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		3 / 3 GLU C 559
GLY C 562
THR C 561
 None
 0.51A 3iazA-4yfaC:
undetectable		 3iazA-4yfaC:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		4 / 7 TRP C 550
GLU C 338
VAL C 335
VAL C 511
 None
 1.16A 3jx4A-4yfaC:
undetectable
3jx4B-4yfaC:
undetectable		 3jx4A-4yfaC:
21.42
3jx4B-4yfaC:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		4 / 7 VAL C 335
VAL C 511
TRP C 550
GLU C 338
 None
 1.15A 3jx5A-4yfaC:
undetectable
3jx5B-4yfaC:
undetectable		 3jx5A-4yfaC:
21.42
3jx5B-4yfaC:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		4 / 7 VAL C 335
VAL C 511
TRP C 550
GLU C 338
 None
 1.12A 3jx6A-4yfaC:
undetectable
3jx6B-4yfaC:
undetectable		 3jx6A-4yfaC:
21.46
3jx6B-4yfaC:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		3 / 3 VAL C 340
VAL C 335
TRP C 550
 None
 0.95A 3l8lC-4yfaC:
undetectable
3l8lD-4yfaC:
undetectable		 3l8lC-4yfaC:
3.66
3l8lD-4yfaC:
3.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		4 / 7 TRP C 550
GLU C 338
VAL C 335
VAL C 511
 None
 1.17A 3n61A-4yfaC:
undetectable
3n61B-4yfaC:
undetectable		 3n61A-4yfaC:
21.42
3n61B-4yfaC:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		4 / 7 VAL C 335
VAL C 511
TRP C 550
GLU C 338
 None
 1.12A 3nljA-4yfaC:
undetectable
3nljB-4yfaC:
undetectable		 3nljA-4yfaC:
21.46
3nljB-4yfaC:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		5 / 12 GLY A  60
SER A  86
ILE A  94
ASP A  87
ASN A  83
 None
 1.17A 3q87B-4yfaA:
undetectable		 3q87B-4yfaA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		3 / 3 LEU A  72
ARG A  91
ASN A 174
 None
 0.77A 3qxvD-4yfaA:
undetectable		 3qxvD-4yfaA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		3 / 3 LEU A  78
ARG A  91
ASN A 174
 None
 0.68A 3qxvD-4yfaA:
undetectable		 3qxvD-4yfaA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		5 / 12 ASN C 276
GLY C 312
GLY C 275
MET C 311
PHE C 346
 None
 1.41A 3r24A-4yfaC:
undetectable		 3r24A-4yfaC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_B_017B202_1
(PROTEASE)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		4 / 7 TRP C 248
ARG C 152
GLY C 129
PRO C 130
 None
 1.30A 3ucbB-4yfaC:
undetectable		 3ucbB-4yfaC:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		4 / 5 LEU C 307
ARG C 310
PRO C 424
ALA C 304
 None
 1.30A 3vm4A-4yfaC:
undetectable		 3vm4A-4yfaC:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1001_1
(HEMOLYTIC LECTIN
CEL-III)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		4 / 5 VAL A  24
GLY A  23
TYR C  33
ASP A  46
 None
 1.40A 3w9tA-4yfaA:
undetectable		 3w9tA-4yfaA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB503_1
(HEMOLYTIC LECTIN
CEL-III)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		4 / 5 VAL A  24
GLY A  23
TYR C  33
ASP A  46
 None
 1.41A 3w9tB-4yfaA:
undetectable		 3w9tB-4yfaA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1001_1
(HEMOLYTIC LECTIN
CEL-III)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		4 / 5 VAL A  24
GLY A  23
TYR C  33
ASP A  46
 None
 1.39A 3w9tC-4yfaA:
undetectable		 3w9tC-4yfaA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD502_1
(HEMOLYTIC LECTIN
CEL-III)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		4 / 5 VAL A  24
GLY A  23
TYR C  33
ASP A  46
 None
 1.40A 3w9tD-4yfaA:
undetectable		 3w9tD-4yfaA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE504_1
(HEMOLYTIC LECTIN
CEL-III)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		4 / 5 VAL A  24
GLY A  23
TYR C  33
ASP A  46
 None
 1.40A 3w9tE-4yfaA:
undetectable		 3w9tE-4yfaA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF504_1
(HEMOLYTIC LECTIN
CEL-III)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		4 / 5 VAL A  24
GLY A  23
TYR C  33
ASP A  46
 None
 1.40A 3w9tF-4yfaA:
undetectable		 3w9tF-4yfaA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG504_1
(HEMOLYTIC LECTIN
CEL-III)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		4 / 5 VAL A  24
GLY A  23
TYR C  33
ASP A  46
 None
 1.40A 3w9tG-4yfaA:
undetectable		 3w9tG-4yfaA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD392_1
(TETX2 PROTEIN)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		4 / 5 HIS C 522
SER C 333
GLN C 520
VAL C  17
 None
 1.12A 4a99D-4yfaC:
undetectable		 4a99D-4yfaC:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7;
Acidovorax
sp.
MR-S7) 		4 / 6 THR C 523
TYR C 508
HIS A  26
TYR C 541
 None
 1.45A 4df2A-4yfaC:
undetectable		 4df2A-4yfaC:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7;
Acidovorax
sp.
MR-S7) 		5 / 12 ASN A 160
ASP C 206
GLY C 208
GLN C 256
ILE C 187
 None
 1.39A 4djeA-4yfaA:
undetectable		 4djeA-4yfaA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7;
Acidovorax
sp.
MR-S7) 		5 / 12 ASN A 160
ASP C 206
GLY C 208
GLN C 256
ILE C 187
 None
 1.38A 4djfA-4yfaA:
undetectable		 4djfA-4yfaA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		3 / 3 TYR A 157
GLN C 256
TRP C 189
 None
None
DKA  C 601 (-3.8A)
 1.11A 4kn2C-4yfaA:
undetectable		 4kn2C-4yfaA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		3 / 3 TYR A 165
GLN C 256
TRP C 189
 None
None
DKA  C 601 (-3.8A)
 1.16A 4kn2C-4yfaA:
undetectable		 4kn2C-4yfaA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		4 / 8 GLY C 518
THR C 556
ARG C 197
PHE C 555
 None
 1.21A 4m5mA-4yfaC:
undetectable		 4m5mA-4yfaC:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		5 / 11 ALA C  65
SER C 173
SER C  63
GLY C 196
THR C 192
 None
 1.06A 4mmaA-4yfaC:
undetectable		 4mmaA-4yfaC:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		4 / 6 ASP C 153
VAL C 210
SER C  71
ALA A 162
 None
 1.05A 4nedA-4yfaC:
undetectable		 4nedA-4yfaC:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		4 / 8 LEU A  48
THR A  50
ARG C  31
HIS C 538
 None
 1.08A 4qknA-4yfaA:
undetectable		 4qknA-4yfaA:
16.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YFB_C_PACC601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		12 / 12 SER C   1
PRO C  22
TRP C  24
PHE C  32
PHE C  50
GLN C  57
ILE C  58
HIS C  68
VAL C  70
TRP C 165
TRP C 189
VAL C 190
 DKA  C 601 (-2.5A)
None
DKA  C 601 (-4.3A)
None
DKA  C 601 ( 4.5A)
DKA  C 601 (-4.3A)
None
DKA  C 601 (-4.8A)
DKA  C 601 (-4.6A)
DKA  C 601 (-4.8A)
DKA  C 601 (-3.8A)
DKA  C 601 ( 4.8A)
 0.17A 4yfbC-4yfaC:
66.2		 4yfbC-4yfaC:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YFB_F_PACF601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		12 / 12 SER C   1
PRO C  22
TRP C  24
PHE C  32
PHE C  50
GLN C  57
ILE C  58
HIS C  68
VAL C  70
TRP C 165
TRP C 189
VAL C 190
 DKA  C 601 (-2.5A)
None
DKA  C 601 (-4.3A)
None
DKA  C 601 ( 4.5A)
DKA  C 601 (-4.3A)
None
DKA  C 601 (-4.8A)
DKA  C 601 (-4.6A)
DKA  C 601 (-4.8A)
DKA  C 601 (-3.8A)
DKA  C 601 ( 4.8A)
 0.19A 4yfbF-4yfaC:
66.4		 4yfbF-4yfaC:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YFB_I_PACI601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		12 / 12 SER C   1
PRO C  22
TRP C  24
PHE C  32
PHE C  50
GLN C  57
ILE C  58
HIS C  68
VAL C  70
TRP C 165
TRP C 189
VAL C 190
 DKA  C 601 (-2.5A)
None
DKA  C 601 (-4.3A)
None
DKA  C 601 ( 4.5A)
DKA  C 601 (-4.3A)
None
DKA  C 601 (-4.8A)
DKA  C 601 (-4.6A)
DKA  C 601 (-4.8A)
DKA  C 601 (-3.8A)
DKA  C 601 ( 4.8A)
 0.21A 4yfbI-4yfaC:
64.9		 4yfbI-4yfaC:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YFB_L_PACL601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		12 / 12 SER C   1
PRO C  22
TRP C  24
PHE C  32
PHE C  50
GLN C  57
ILE C  58
HIS C  68
VAL C  70
TRP C 165
TRP C 189
VAL C 190
 DKA  C 601 (-2.5A)
None
DKA  C 601 (-4.3A)
None
DKA  C 601 ( 4.5A)
DKA  C 601 (-4.3A)
None
DKA  C 601 (-4.8A)
DKA  C 601 (-4.6A)
DKA  C 601 (-4.8A)
DKA  C 601 (-3.8A)
DKA  C 601 ( 4.8A)
 0.18A 4yfbL-4yfaC:
66.0		 4yfbL-4yfaC:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		4 / 8 ALA A 159
HIS A  90
ARG A 155
THR A  77
 DKA  C 601 (-3.9A)
None
None
None
 1.01A 5db5A-4yfaA:
undetectable
5db5B-4yfaA:
undetectable		 5db5A-4yfaA:
19.21
5db5B-4yfaA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7;
Acidovorax
sp.
MR-S7) 		4 / 7 GLU C 573
GLY A 116
GLY A  38
ALA A 118
 None
 0.94A 5e26A-4yfaC:
undetectable
5e26B-4yfaC:
undetectable		 5e26A-4yfaC:
22.57
5e26B-4yfaC:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7;
Acidovorax
sp.
MR-S7) 		4 / 8 ALA A 118
GLU C 573
GLY A 116
GLY A  38
 None
 0.91A 5e26C-4yfaA:
undetectable
5e26D-4yfaA:
undetectable		 5e26C-4yfaA:
19.36
5e26D-4yfaA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		6 / 12 TYR A 165
ILE C 154
ALA C 209
PHE C  79
GLY C 129
GLY C 156
 None
 1.45A 5i73A-4yfaA:
undetectable		 5i73A-4yfaA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		4 / 8 HIS C 396
SER C 403
VAL C 446
SER C 449
 None
 1.01A 5m8rB-4yfaC:
undetectable		 5m8rB-4yfaC:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE
(Acidovorax
sp.
MR-S7) 		5 / 12 THR C 523
GLN C 510
VAL C  64
SER C 333
VAL C 336
 None
 1.25A 6bzoC-4yfaC:
0.3		 6bzoC-4yfaC:
20.38